Benzenesulfonamides
Sigma Aldrich Fine Chemicals Biosciences Glimepiride >=98% (HPLC), solid | 93479-97-1 | MFCD00878417 | 250MG
Glimepiride >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 490.62 | 93479-97-1 | MFCD00878417 | 250MG
Sigma Aldrich Fine Chemicals Biosciences GSK137647A >=98% (HPLC) | 349085-82-1 | MFCD02007969 | 5MG
GSK137647A >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 305.39 | 349085-82-1 | MFCD02007969 | 5MG
Apexbio Technology LLC Bosentan Hydrate 157212-55-0 10mM (in 1mL DMSO)
Bosentan Hydrate (CAS 157212-55-0) is a sulfonamide-derived competitive antagonist of endothelin receptors exhibiting preferential affinity toward endothelin A over endothelin B receptors By interfering with endothelin-triggered signaling in endothelial and vascular smooth muscle cells it attenuates vasoconstrictive and bronchoconstrictive responses In vitro studies revealed bosentan inhibited endothelin receptor activity in P388/dx cells (IC50 15 1 1 6 M) and effectively reversed antiangiogenic effects of systemic sclerosis patient sera on dermal microvascular endothelial cells In animal models bosentan administration post-myocardial infarction significantly elevated plasma leptin levels Clinically bosentan is applied extensively in research on pulmonary arterial hypertension showing beneficial outcomes on patients exercise capacity
Apexbio Technology LLC Benzenesulfonamide 98-10-2 500mg
Benzenesulfonamide (CAS 98-10-2) is an amide derivative of benzenesulfonic acid widely utilized as a synthetic intermediate for pharmaceuticals and other chemicals Mechanistically benzenesulfonamide derivatives have been investigated for their inhibitory activity against various human carbonic anhydrases (CAs) with certain 4-substituted diazo derivatives exhibiting strong binding affinity particularly for CA I and II isoforms as demonstrated by isothermal titration calorimetry and fluorescence-based thermal shift assays In in vivo models indole-based benzenesulfonamide derivatives show oral activity in rat and sheep models of airway inflammation attenuating physiological responses to antigenic or cholinergic challenge Benzenesulfonamide remains in preclinical evaluation
Medchemexpress LLC GW806742X hydrochloride | 98.3% | 610.01 | 10 MG
GW806742X hydrochloride is an ATP mimetic and a potent inhibitor of MLKL (Mixed Lineage Kinase Domain-Like protein), binding to its pseudokinase domain with a Kd of 9.3 μM. It also shows activity against VEGFR2 with an IC50 of 2 nM. This compound effectively retards MLKL membrane translocation and inhibits necroptosis.
- Potent MLKL inhibitor (Kd = 9.3 μM)
- Activity against VEGFR2 (IC50 = 2 nM)
- Retards MLKL membrane translocation
- Inhibits necroptosis
- Inhibits necroptotic death of wild-type mouse dermal fibroblasts in a dose-dependent manner
- Inhibits VEGF induced proliferation of HUVECs with an IC50 of 5 nM
Medchemexpress LLC Glimepiride | 93479-97-1 | MFCD00878417 | 99.92% | C24H34N4O5S | 1 G
Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound. It lowers blood glucose more effectively than glibenclamide and is generally associated with a lower risk of hypoglycemia and less weight gain compared to other sulfonylureas. Its use may be safer for patients with cardiovascular disease due to its lack of detrimental effects on ischemic preconditioning.
- Lowers blood glucose more effectively than glibenclamide.
- Decreases extracellular Aβ40 and Aβ42 levels.
- Associated with lower risk of hypoglycemia.
- Associated with less weight gain compared to other sulfonylureas.
- May be safer for patients with cardiovascular disease.
Chem-Impex International, Inc. 2-Nitrobenzenesulfonamide | MFCD00009807 | 25G
2-Nitrobenzenesulfonamide, MFCD00009807, 25G
Medchemexpress LLC HY-100727 5mg Medchemexpress, AM-2099 CAS:1443373-17-8 Purity:>98%
Medchemexpress, HY-100727 5mg AM-2099 CAS:1443373-17-8 AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC 50 of 0.16 μM for human Nav1.7. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Aldrich Fine Chemicals Biosciences Tamsulosin hydrochloride European Pharmacopoeia (EP) Reference Standard | 106463-17-6 | MFCD00922997 |
Tamsulosin hydrochloride European Pharmacopoeia (EP) Reference Standard | Mol Wt: 444.97 | 106463-17-6 | MFCD00922997 |
Medchemexpress LLC Sildenafil | 139755-83-2 | MFCD00867528 | 99.99% | 474.58 | 100 MG
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It has been shown to potentiate the phosphorylation of ERK1/ERK2, increase the percentage of cells in S phase, and enhance cell proliferation in vitro. In animal models, it significantly increases intracavernosal pressure and has been observed to decrease flap necrosis by increasing the secretion of growth factors.
- Potent phosphodiesterase type 5 (PDE5) inhibitor.
- Increases intracavernosal pressure.
- Potentiates phosphorylation of ERK1/ERK2.
- Increases cell proliferation.
- Decreases flap necrosis by increasing growth factor secretion.
Selleck Chemical LLC EG00229-E1119-5MG
EG00229 is a neuropilin 1 (NRP1) receptor antagonist with an IC50 of 3 M against VEGF-A binding to NRP1 b1 domain
Medchemexpress LLC GSK8612 | 2361659-62-1 | 99.6% | 520.33 | 100 MG
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. It is intended for research use only and not for sale to patients. In vitro, GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, it inhibits the secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING.
- Highly selective and potent tank-binding kinase-1 (TBK1) inhibitor.
- pIC50 of 6.8 for recombinant TBK1.
- Inhibits TLR3-induced IRF3 phosphorylation in Ramos cells.
- Inhibits type I IFN secretion in primary human mononuclear cells.
- Inhibits secretion of IFNβ in response to dsDNA and cGAMP in THP1 cells.
Medchemexpress LLC N-desmethyl sildenafil | 139755-82-1 | MFCD00908398 | 99.5% | 460.55 g/mol | C21H28N6O4S | 10 MG
N-Desmethyl sildenafil is the major N-desmethyl metabolite of sildenafil and is supplied as a high-purity analytical standard for research and analytical applications related to phosphodiesterase type 5 (PDE5) activity and metabolism. The compound is characterized by a defined molecular formula and molecular weight, and is provided in small milligram pack sizes for reference and trace-level analyses.
- High purity (≈99.5%) suitable for analytical and reference use.
- Intended for analytical, reference, and research applications related to PDE5 activity.
- Available in small milligram pack sizes for trace-level studies.
- Molecular formula C21H28N6O4S; molecular weight approximately 460.55 g/mol.
- Store powder at -20°C for long-term stability; follow solvent storage guidelines for solutions.
Medchemexpress LLC 7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene | 84030-20-6 | C8H15N3 | 25 G
7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene | 84030-20-6 | C8H15N3 | 25 G
Medchemexpress LLC N-desmethyl sildenafil | 139755-82-1 | MFCD00908398 | 99.5% | 460.55 | C21H28N6O4S | 25 MG
N-desmethyl sildenafil is the primary N-desmethylated metabolite of sildenafil supplied as an analytical reference standard for laboratory research. It is available in solid and solution formats for analytical applications and quality control, and is intended for research use only (not for human or clinical use).
- Provided as solid and solution formats for flexibility in assays.
- High purity (99.5%) suitable for analytical and reference standard use.
- Molecular formula C21H28N6O4S; molecular weight 460.55.
- Used in pharmacokinetic, metabolite identification, and analytical method development studies.
- Available in multiple small-scale pack sizes for laboratory workflows.