Benzenesulfonic acids and derivatives
eMolecules 80-48-8 | Methyl 4-toluenesulfonate | Oakwood Chemicals | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 100g | 480156146
Methyl 4-toluenesulfonate | Oakwood Chemicals | 80-48-8 | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 100g | 480156146
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 1 ML
I-138 is an orally active, reversible inhibitor of USP1-UAF1, with an IC50 of 4.1 nM and Ki of 5.4 nM. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells. It is intended for research use only.
- Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
- Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
- Dose-dependently inhibits MDA-MB-436 cell viability
- Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
- Benefits BRCA1/2 mutant tumor inhibition in vivo when combined with Niraparib
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 25 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1, with an IC50 of 4.1 nM and a Ki of 5.4 nM. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells. It is structurally related to ML323.
- Reversible inhibitor of USP1-UAF1
- Induces monoubiquitination of FANCD2 and PCNA in cells
- Eliminates USP1 autocleavage in cells
- Inhibits MDA-MB-436 cell viability
- Shows modest antitumor activity in mice bearing MDA-MB-436 tumors
- Can be combined with Niraparib for BRCA1/2 mutant tumor inhibition
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 1 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
- Orally active and reversible inhibitor of USP1-UAF1.
- Potent inhibitory activity against USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM).
- Induces monoubiquitination of FANCD2 and PCNA in cells.
- Eliminates USP1 autocleavage in cells.
- Demonstrates modest antitumor activity in mice bearing MDA-MB-436 tumors.
- Shows enhanced inhibition of BRCA1/2 mutant tumors in vivo when combined with the PARP inhibitor Niraparib.
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 100 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage. This compound is structurally related to ML323.
- Orally active and reversible inhibitor of USP1-UAF1
- Induces monoubiquitination of FANCD2 and PCNA in cells
- Eliminates USP1 autocleavage in cells
- Shows dose-dependent inhibition of MDA-MB-436 cell viability
- Exhibits modest antitumor activity in mice bearing MDA-MB-436 tumors
- Can be combined with Niraparib for BRCA1/2 mutant tumor inhibition in vivo
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 50 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
- Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
- Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
- Dose-dependently inhibits MDA-MB-436 cell viability
- Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
- Benefits BRCA1/2 mutant tumor inhibition when combined with Niraparib
eMolecules 77182-82-2 | DL-Phosphinothricin, monoammonium salt | Apollo Scientific198.159 | C5H15N2O4P | 0.000 | N.CP(O)(=O)CCC(N)C(O)=O | 1g | 562428419
DL-Phosphinothricin, monoammonium salt | Apollo Scientific | 77182-82-2198.159 | C5H15N2O4P | 0.000 | N.CP(O)(=O)CCC(N)C(O)=O | 1g | 562428419
![eMolecules 17625-03-5 | 3-Sulfobenzoic acid monosodium salt | Combi-Blocks, Inc. | MFCD00066378 | 224.160 | C7H5NaO5S | 95.000 | [Na+].OC(=O)c1cccc(c1)S([O-])(=O)=O | 25g | 603138216](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184095.JPG-250.jpg)
eMolecules 17625-03-5 | 3-Sulfobenzoic acid monosodium salt | Combi-Blocks, Inc. | MFCD00066378 | 224.160 | C7H5NaO5S | 95.000 | [Na+].OC(=O)c1cccc(c1)S([O-])(=O)=O | 25g | 603138216
3-Sulfobenzoic acid monosodium salt | Combi-Blocks, Inc. | 17625-03-5 | MFCD00066378 | 224.160 | C7H5NaO5S | 95.000 | [Na+].OC(=O)c1cccc(c1)S([O-])(=O)=O | 25g | 603138216
Medchemexpress LLC Setmelanotide (monoacetate) | 2759937-80-7 | 99.8% | 1177.36 | 25 MG
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist. It acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively, and is intended for research use only.
- Acts on human and rat MC4R
- Stable as a solid
- Suitable for research use
Medchemexpress LLC 2-Ketoglutaric acid-d6 | 1173021-86-7 | 98.6% | 152.14 | 10 MG
2-Ketoglutaric acid-d6 is the deuterium labeled variant of 2-Ketoglutaric acid. It is an intermediate in the Krebs cycle for ATP or GTP production and serves as the primary carbon skeleton for nitrogen-assimilatory reactions. This compound also acts as a reversible inhibitor of tyrosinase (IC50=15 mM).
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated for potential impact on pharmacokinetic and metabolic profiles of drugs.
Selleck Chemical LLC 2-Ketoglutaric acid
2-Ketoglutaric acid (alpha-ketoglutarate) is a key molecule in the TCA cycle playing a fundamental role in determining the overall rate of this important metabolic process In the TCA cycle AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase which functions as a key control point of the TCA cycle 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase
Cayman Chemical a-KetoglutarIc AcId 500g
An intermediate in the citric acid cycle; precursor of glutamine and glutamate and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development
Cayman Chemical a-KetoglutarIc AcIdodIum s 1g
An intermediate in the citric acid cycle; precursor of glutamine and glutamate and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development
Cambridge Isotope Laboratories Alpha-Ketoglutaric acid disodium salt (1 2 3 4-13C4 99%) 0 1 mg
Alpha-Ketoglutaric acid disodium salt (1 2 3 4-13C4 99%) 0 1 mg
