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Filtered Search Results
Selleck Chemical LLC Tamoxifen-500mg
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Tamoxifen is an orally active, selective estrogen receptor modulator (SERM) which exhibits both estrogenic agonist and antagonist effects. It blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity.
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Medchemexpress LLC HY-15238A 5mg Medchemexpress, ST-836 (hydrochloride) CAS:1415564-68-9 Purity:>98%
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Medchemexpress, HY-15238A 5mg ST-836 (hydrochloride) CAS:1415564-68-9 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC RVX-297 100mg | 1044871-04-6 | 100 MG
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RVX-297 is a BD2-selective BET bromodomain inhibitor provided as a research compound for studying bromodomain-mediated regulation of gene expression and inflammation. It is supplied as a powder with defined purity and storage recommendations for laboratory use.
- BD2-selective BET bromodomain inhibitor for in vitro and in vivo research.
- Shown to suppress inflammatory gene expression in multiple immune cell models.
- Supplied as a powder with specified storage conditions to maintain stability.
- Common applications include studies of inflammation, autoimmunity, and epigenetic regulation.
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Medchemexpress LLC Lenvatinib | 417716-92-8 | 100mg
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Lenvatinib | 417716-92-8 | 100mg
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Medchemexpress LLC HY-19340 5mg Medchemexpress, TMS CAS:24144-92-1 Purity:>98%
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Medchemexpress, HY-19340 5mg TMS CAS:24144-92-1 TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC5098% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Iwp-4 | 686772-17-8 | MFCD04457754 | 99.8% | 496.62 g/mol | C23H20N4O3S3 | 5 MG
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IWP-4 is a small-molecule inhibitor of Wnt/β-catenin signaling that inactivates the acyltransferase Porcn, with an in vitro IC50 of 25 nM. Supplied as a solid for research use, it is used to block Wnt secretion and study Wnt-dependent processes in cell and developmental biology assays.
- Potent Porcn inhibitor, IC50 = 25 nM.
- Blocks Wnt secretion and downstream β-catenin signaling.
- High chemical purity suitable for in vitro assays.
- Available in multiple small-mass pack sizes for dosing flexibility.
- Soluble in DMSO for cell-based and biochemical studies.
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Medchemexpress LLC HY-14710 10mg Medchemexpress, AZ3146 CAS:1124329-14-1 Purity:>98%
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Medchemexpress, HY-14710 10mg AZ3146 CAS:1124329-14-1 AZ3146 is a reasonably potent and selective Mps1 inhibitor with IC50 of 35 nM for Mps1Cat. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-16500 5mg Medchemexpress, Tolrestat CAS:82964-04-3 Purity:>98%
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Medchemexpress, HY-16500 5mg Tolrestat CAS:82964-04-3 Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG
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Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive CHK1 inhibitor
- Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
- Induces double-stranded DNA breakage and replication catastrophe
- Leads to apoptosis and potent anti-tumor activity
- Inhibits MELK, SIK, BRSK2, and ARK5
- Requires CDC25A and CDK2 for DNA damage
- Causes DNA damage during S-phase
- Inhibits CHK1 and CHK2 autophosphorylation
- Induces cell-cycle shift with H2AX phosphorylation
- Triggers chromosomal fragmentation and replication stress
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Aobchem AOBCHEM
5001063046 4- 4- TRIFLUOROMETHOXY PHENOXY
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Aobchem AOBCHEM
5001063047 4- 4- TRIFLUOROMETHOXY PHENOXY
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Aobchem AOBCHEM
5001063064 4- 4- TRIFLUOROMETHOXY PHENOXY
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Medchemexpress LLC HY-N0690 10mg Medchemexpress, Schisandrin C CAS:61301-33-5 Purity:>98%
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Medchemexpress, HY-N0690 10mg Schisandrin C CAS:61301-33-5 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC KU-57788 | 503468-95-9 | 100.0% | 413.49 | 1 ML
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KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. It acts as an NHEJ pathway inhibitor, and also inhibits PI3K and mTOR with IC50s of 5.0 μM and 1.7 μM, respectively.
- Highly potent and selective DNA-PK inhibitor (IC50 of 14 nM)
- NHEJ pathway inhibitor
- Inhibits PI3K (IC50 of 5.0 μM) and mTOR (IC50 of 1.7 μM)
- Inhibits the growth of liver cancer HepG2 cells dose- and time-dependently
- Reduces pDNA-PKcs (S2056) protein expression in liver cancer cells
- Affects DNA damage repair when double treated with 60Coγ IR
- Reduces the frequency of NHEJ and increases the rate of HDR following Cas9-mediated DNA cleavage
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Medchemexpress LLC HY-15338 10mg Medchemexpress, TG003 CAS:719277-26-6 Purity:>98%
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Medchemexpress, HY-15338 10mg TG003 CAS:719277-26-6 TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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