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Filtered Search Results
Medchemexpress LLC FR194738 | 204067-52-7 | 99.8% | 476.11 | C27H38ClNO2S | 25 MG
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FR194738 is a small-molecule squalene epoxidase inhibitor for preclinical research. It inhibits squalene epoxidase activity in HepG2 cell homogenates (IC50 = 9.8 nM) and is provided with analytical characterization suitable for biochemical and cellular studies.
- Potent squalene epoxidase inhibitor (IC50 = 9.8 nM).
- Suitable for biochemical and cell-based assays.
- High purity appropriate for analytical applications (~99.8%).
- Characterized by CAS number 204067-52-7 and molecular weight 476.11.
- Available in multiple vial sizes, including 25 mg.
- Supplied with supporting documentation: datasheet, COA, SDS, H NMR, LCMS.
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Medchemexpress LLC Tcmdc-135051 hydrochloride | 2705545-47-5 | 98.2% | 508.05 | C29H34ClN3O3 | 100MG
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TCMDC-135051 hydrochloride is the hydrochloride salt of TCMDC-135051, a selective and potent inhibitor of Plasmodium falciparum cyclin-dependent-like kinase 3 (PfCLK3) intended for research use in biochemical and cellular studies.
- selective PfCLK3 inhibition with low off-target toxicity.
- high purity suitable for research applications.
- light yellow to yellow solid form for easy handling.
- stable when stored sealed and protected from moisture.
- provided in small quantities for assay development and screening.
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Selleck Chemical LLC Doravirine
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Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12 9 7 and 9 7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants respectively in a biochemical assay It is highly specific with minimum off-target activities
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Cambridge Isotope Laboratories 3-Phenoxybenzoic acid (phenoxy-13C6 99%) 100 ug/mL in acetonitrile 1 2 mL
3-Phenoxybenzoic acid (phenoxy-13C6 99%) 100 ug/mL in acetonitrile 1 2 mL
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Medchemexpress LLC 1,3-Dimethoxybenzene-d10 | 340257-57-0 | 98% | 148.23 | 5 MG
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1,3-Dimethoxybenzene-d10 is the deuterium labeled 1,3-Dimethoxybenzene. It belongs to the class of organic compounds known as dimethoxybenzenes and is an intermediate in the synthesis of organic compounds. It is for research use only.
- Deuterium labeled compound.
- Belongs to dimethoxybenzenes.
- Intermediate in organic compound synthesis.
- Purity: 98%.
- Appearance: liquid, colorless to light yellow.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes like deuterium have the potential to affect the pharmacokinetic and metabolic profiles of drugs.
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Medchemexpress LLC 1,3-Dimethoxybenzene-d10 | 340257-57-0 | 98% | 148.23 | 100 MG
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1,3-Dimethoxybenzene-d10 is the deuterium labeled version of 1,3-Dimethoxybenzene. It belongs to the class of organic compounds known as dimethoxybenzenes and serves as an intermediate in the synthesis of organic compounds. This product is for research use only.
- Deuterium-labeled compound.
- Can be utilized as a tracer.
- Can be used as an internal standard for quantitative analysis.
- Suitable for techniques like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated for quantitation during drug development.
- Deuteration can potentially influence drug pharmacokinetics and metabolism.
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![eMolecules Medchem Express / JMV 2959 / 5mg / 415690756 / HY-U00433 / / 925238-89-7 / [null] / 508.626 / C30H32N6O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502454371.PNG-250.jpg)
eMolecules Medchem Express / JMV 2959 / 5mg / 415690756 / HY-U00433 / / 925238-89-7 / [null] / 508.626 / C30H32N6O2
Medchem Express / JMV 2959 / 5mg / 415690756 / HY-U00433 / / 925238-89-7 / [null] / 508.626 / C30H32N6O2
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Medchemexpress LLC NVP-AST 487 | 630124-46-8 | 98.9% | 529.56 | 100 MG
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AST 487 (NVP-AST 487) is a potent RET kinase inhibitor and also inhibits Flt-3, KDR, c-Kit, and c-Abl kinases. It demonstrates strong inhibitory effects on the growth of human thyroid cancer cell lines with activating RET mutations and mutant FLT3 inhibitor activity, making it suitable for various research applications in cancer and other related disease areas.
- Inhibits RET kinase with an IC50 of 880 nM
- Inhibits Flt-3 with an IC50 of 520 nM
- Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
- Novel, mutant FLT3 inhibitor
- Inhibits KDR, c-Kit, and c-Abl kinase
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Medchemexpress LLC HY-117113 5mg Medchemexpress, JI051 CAS:2234281-75-3 Purity:>98%
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Medchemexpress, HY-117113 5mg JI051 CAS:2234281-75-3 JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![eMolecules Medchem Express / BAY-826 / 5mg / 532149590 / HY-100756 / / 1448316-08-2 / [null] / 558.530 / C26H19F5N6OS](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502460135.PNG-250.jpg)
eMolecules Medchem Express / BAY-826 / 5mg / 532149590 / HY-100756 / / 1448316-08-2 / [null] / 558.530 / C26H19F5N6OS
Medchem Express / BAY-826 / 5mg / 532149590 / HY-100756 / / 1448316-08-2 / [null] / 558.530 / C26H19F5N6OS
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Medchemexpress LLC HY-N0858 5mg Medchemexpress, Gomisin G CAS:62956-48-3 Purity:>98%
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Medchemexpress, HY-N0858 5mg Gomisin G CAS:62956-48-3 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-59105 5mg Medchemexpress, SC-560 CAS:188817-13-2 Purity:>98%
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Medchemexpress, HY-59105 5mg SC-560 CAS:188817-13-2 SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC CCR1 antagonist 9 | 1220026-26-5 | MFCD32690071 | 99.7% | 425.44 g/mol | C20H16FN5O3S | 100MG
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CCR1 antagonist 9 is a small-molecule, selective antagonist of the chemokine receptor CCR1 used for in vitro pharmacology and receptor-target validation. It shows nanomolar potency in functional assays (IC50 6.8 nM in calcium flux) and activity in cell-based chemotaxis (IC50 ~28 nM). The substance is supplied as a solid or as concentrated DMSO solutions, has reported high purity (~99.65%), molecular weight 425.44 g/mol, and CAS 1220026-26-5.
- Selective CCR1 receptor antagonist with nanomolar potency in calcium flux assays.
- Demonstrated activity in cell-based chemotaxis assays.
- High purity suitable for research use.
- Available as solid and concentrated DMSO solutions in multiple sizes.
- Recommended cold storage to preserve stability.
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Medchemexpress LLC Mirificin | 103654-50-8 | 5 MG
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Mirificin is an isoflavone found in Puerariae Lobatae Radix. It acts as a tyrosinase (TYR) inhibitor with an IC50 of 12.66 μM.
- Purity of 99.66%
- Also known as Puerarin apioside
- Inhibits tyrosinase with an IC50 of 12.66 μM
- Molecular weight of 548.49
- Chemical formula C26H28O13
- Solid appearance
- Color ranges from white to light yellow
- Classified as flavonoid, isoflavone, phenol, and polyphenol
- Initially sourced from plants
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Medchemexpress LLC MD2-TLR4-IN-1 | 2249801-12-3 | 98.2% | 100 MG
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MD2-TLR4-IN-1 is an antagonist of the myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages. This product is suitable for research related to acute lung injury (ALI).
- Inhibits NF-κB in RAW264.7 macrophages
- Directly binds to the MD2-TLR4 complex and disrupts its activation
- Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages
- Significantly inhibits dimerization of the MD2-TLR4 complex in LPS-activated mouse primary macrophages (MPMs)
- Reduces airspace inflammation and ameliorates histopathological changes in lung tissues of LPS-challenged mice
- Decreases LPS-induced myeloperoxidase (MPO) activity and serum TNF-α levels
- Lowers mRNA levels of TNF-α, IL-6, IL-1β, IL-12, IL-33, and COX-2 in lung tissues
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