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Filtered Search Results
Medchemexpress LLC PXS-5153A (monohydrochloride) | 2125956-82-1 | 99.6% | 438.95 | 50 MG
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PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorate fibrosis.
- Exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested.
- Also inhibits human LOXL3 with an IC50 value of 63 nM.
- Is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases.
- Is a fast acting inhibitor, with enzymatic activity almost entirely blocked within 15 minutes.
- Reduces crosslinks and ameliorates fibrosis.
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eMolecules 98418-47-4 | Medchem Express | Metoprolol (succinate) | 50mg | 446268543 | HY-17503A | MFCD07391179 | 652.826 | C34H56N2O10
Medchem Express | Metoprolol (succinate) | 50mg | 446268543 | HY-17503A | 98418-47-4 | MFCD07391179 | 652.826 | C34H56N2O10
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eMolecules 1018678-50-6 | 2-(Difluoromethyl)benzaldehyde | ChemScene | MFCD16875639 | 156.132 | C8H6F2O | 96.000 | FC(F)c1ccccc1C=O | 100mg | 801476742
2-(Difluoromethyl)benzaldehyde | ChemScene | 1018678-50-6 | MFCD16875639 | 156.132 | C8H6F2O | 96.000 | FC(F)c1ccccc1C=O | 100mg | 801476742
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Medchemexpress LLC Tirofiban | 144494-65-5 | 98.4% | 440.60 | 50 MG
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Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist. It inhibits fibrinogen binding to this receptor, leading to antithrombotic activity. It also induces proliferation and migration of endothelial cells by stimulating VEGF production, and significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding to the receptor
- Possesses antithrombotic activity
- Induces proliferation and migration of endothelial cells
- Reduces myocardial no-reflow and ischemia-reperfusion injury
- Alleviates myocardial microvascular structural and endothelial dysfunction
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Medchemexpress LLC PRMT5-IN-1 hydrochloride | 99.5% | 455.29 | 10 MG
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PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. It can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions. It is for research use only and not sold to patients.
- Potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor
- IC50 of 11 nM for PRMT5/MEP50
- Inhibits the PRMT5/MEP50 complex very rapidly with a Kinact of 0.068 min-1 and a good binding affinity (KI=55 nM)
- Inhibits the expression of cellular sDMA with an IC50 value of 0.012 μM in Granta-519 cells
- Inhibits cell proliferation in a dose-dependent manner with an IC50 value of 0.06 μM in Granta-519 cells
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eMolecules 621-87-4 | Phenoxyacetone | Medchem Express | MFCD00008767 | 150.177 | C9H10O2 | 98.000 | CC(=O)COc1ccccc1 | 500mg | 832657108
Phenoxyacetone | Medchem Express | 621-87-4 | MFCD00008767 | 150.177 | C9H10O2 | 98.000 | CC(=O)COc1ccccc1 | 500mg | 832657108
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Medchemexpress LLC GSK2945 hydrochloride | 00-00-0 | 99.7% | 457.80 g/mol | C20H19Cl3N2O2S | 5 MG
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GSK2945 hydrochloride is the hydrochloride salt of a small-molecule antagonist of the nuclear receptor Rev-erbα, supplied for preclinical research. It has reported EC50 values of 21.5 μM (mouse) and 20.8 μM (human) and has been used to increase CYP7A1 levels and modulate cholesterol metabolism.
- High chemical purity (99.7%).
- Solid form suitable for storage at 4°C; in solution store under nitrogen at -80°C (6 months) or -20°C (1 month).
- Soluble in DMSO (~20.83 mg/mL); in vivo formulations and protocols are available for suspension or clear solution preparations.
- Activity: Rev-erbα antagonist with reported EC50 around 21 μM in cell-based assays.
- Provided for research use with supporting assay and formulation data.
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Medchemexpress LLC Nutlin carboxylic acid | 2249750-27-2 | 98.6% | 100 MG
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Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand designed to form PROTACs (Proteolysis-Targeting Chimeras). These PROTACs operate by harnessing the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins. It has a molecular weight of 639.53 and a chemical formula of C32H32Cl2N4O6, appearing as a white to yellow solid.
- Nutlin 3-based MDM2 ligand
- Forms PROTACs via a linker
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
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eMolecules 52603-58-4 | N-(2-Aminobenzothiazol-6-yl)benzamide | Oakwood Chemical | MFCD00608286 | 269.320 | C14H11N3OS | 90.000 | Nc1nc2ccc(NC(=O)c3ccccc3)cc2s1 | 100mg | 537683356
N-(2-Aminobenzothiazol-6-yl)benzamide | Oakwood Chemical | 52603-58-4 | MFCD00608286 | 269.320 | C14H11N3OS | 90.000 | Nc1nc2ccc(NC(=O)c3ccccc3)cc2s1 | 100mg | 537683356
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![eMolecules 55120-75-7 | Calcium trifluoromethanesulfonate | ChemScene189.140 | CCaF3O3S | 98.000 | [Ca++].[O-]S(=O)(=O)C(F)(F)F | 25g | 582635116](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502484614.JPG-250.jpg)
eMolecules 55120-75-7 | Calcium trifluoromethanesulfonate | ChemScene189.140 | CCaF3O3S | 98.000 | [Ca++].[O-]S(=O)(=O)C(F)(F)F | 25g | 582635116
Calcium trifluoromethanesulfonate | ChemScene | 55120-75-7189.140 | CCaF3O3S | 98.000 | [Ca++].[O-]S(=O)(=O)C(F)(F)F | 25g | 582635116
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Medchemexpress LLC HY-110266 5mg Medchemexpress, GN44028 CAS:1421448-26-1 Purity:>98%
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Medchemexpress, HY-110266 5mg GN44028 CAS:1421448-26-1 GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 444308-32-1 | 1-(4-Fluorophenyl)propan-2-ol | MFCD11934388 | 250mg
Ambeed | (R)-2-Hydroxy-122-triphenylethyl acetate | 1g | 552745424 | A587401 | 95061-47-5 | MFCD00066242 | 332.399 | C22H20O3
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Medchemexpress LLC Mitochondrial respiration-IN-1 hydrobromide | 00-00-0 | 99.9% | C26H26Br2NO2PS | 10MG
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Mitochondrial respiration-IN-1 hydrobromide is a small-molecule inhibitor of mitochondrial respiration provided as the hydrobromide salt for biochemical and cellular research. It significantly reduces mitochondrial respiration in platelets and is supplied as a white to off-white solid suitable for in vitro studies.
- High purity (99.92%).
- Soluble in water (100 mg/mL) and DMSO (66.67 mg/mL); ultrasonic assistance may be required.
- Stable when stored sealed away from moisture; in solution: -80°C (6 months) and -20°C (1 month).
- White to off-white solid appearance.
- Suitable for studies of mitochondrial function and platelet respiration.
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Medchemexpress LLC Eliglustat-d4 | 491833-29-5 | 98.0% | 408.57 | 1 MG
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Eliglustat-d4 is the deuterium-labeled version of Eliglustat. Eliglustat is a specific, potent, and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM. Deuteration, the incorporation of stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules, is used as a tracer for quantitation during drug development and has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Specific, potent, and orally active glucocerebroside synthase inhibitor (IC50 of 24 nM).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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Advanced Chemblocks Inc 3-PHENOXY-CYCLOBUTANECAR 250MG
3-PHENOXY-CYCLOBUTANECARBOXYLIC ACID | Mol Wt: 192.213 | 1263284-46-3 | MFCD17014858 | 250 mg
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