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Phenoxy compounds

Organic compounds that have one or more phenyl groups that are bonded to an oxygen with a radical electron; includes compounds with additional substitutions.

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1

eMolecules​ Medchem Express / ML241 (hydrochloride) / 5mg / 446270363 / HY-19797A / / 2070015-13-1 / MFCD30187511 / 408.930 / C23H25ClN4O

Medchem Express / ML241 (hydrochloride) / 5mg / 446270363 / HY-19797A / / 2070015-13-1 / MFCD30187511 / 408.930 / C23H25ClN4O

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2

eMolecules​ Medchem Express / RN-1 (dihydrochloride) / 5mg / 686240167 / HY-110130 / / 1781835-13-9 / [null] / 452.420 / C23H31Cl2N3O2

Medchem Express / RN-1 (dihydrochloride) / 5mg / 686240167 / HY-110130 / / 1781835-13-9 / [null] / 452.420 / C23H31Cl2N3O2

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3

Medchemexpress LLC HY-100518 50mg Medchemexpress, T-26c CAS:869296-13-9 Purity:>98%
SDP

Medchemexpress, HY-100518 50mg T-26c CAS:869296-13-9 T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC 50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4

Medchemexpress LLC HY-11006 100mg , KU-57788 NU7441 CAS:503468-95-9 Purity:98%
SDP

Medchemexpress, HY-11006 100mg KU-57788 NU7441 CAS:503468-95-9 Formula:C25H19NO3S IC50: 13 nM (DNA-PK) , 1 μM (BRD4), 3.5 μM (BRDT) Purity:98% KU-57788 is a potent and selective inhibitor of DNA-PK , with an IC 50 of 13 nM, and also increases CRISPR/Cas9 -mediated editing frequencies. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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5

Medchemexpress LLC HY-59105 5mg Medchemexpress, SC-560 CAS:188817-13-2 Purity:>98%
SDP

Medchemexpress, HY-59105 5mg SC-560 CAS:188817-13-2 SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6

Medchemexpress LLC Kgp-IN-1 (hydrochloride) | 2097865-47-7 | 97.2% | 468.87 | C19H25ClF4N4O3 | 5 MG
SDP

Kgp-IN-1 hydrochloride is the hydrochloride salt of Kgp-IN-1, an arginine-specific gingipain (Rgp) inhibitor described in patent WO2017201322A1 (compound 13-R). It is supplied as a white to off-white solid for biochemical and pharmacological research, with reported purity of 97.18% and molecular weight 468.87 g·mol⁻¹.

  • Arginine-specific gingipain inhibitor useful for Rgp-targeted studies.
  • High purity suitable for in vitro research.
  • Available as solid and as pre-made DMSO solution formats.
  • White to off-white solid for reliable handling.
  • Structural and spectral identifiers provided for cheminformatics use.

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7

Apexbio Technology LLC LRRK2-IN-1 1234480-84-2 10mg
SDP

LRRK2-IN-1 (CAS 1234480-84-2) is a selective small-molecule inhibitor of leucine-rich repeat kinase 2 (LRRK2) a cytoplasmic kinase implicated in Parkinson s disease and Crohn s disease pathogenesis LRRK2-IN-1 competitively inhibits ATP binding to LRRK2 demonstrating an in vitro IC50 of 13 nM against wild-type LRRK2 and 6 nM against the G2019S mutant In HEK293 cells expressing GFP-tagged wild-type or G2019S LRRK2 it shows dose-dependent inhibition with IC50 values of 0 17 M and 0 04 M respectively The compound displays selectivity towards LRRK2 over other kinases and does not affect LRRK1 LRRK2-IN-1 is utilized to investigate LRRK2 signaling pathways phosphorylation events and disease-related mutations in neurodegeneration and inflammation research

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8

Medchemexpress LLC HY-111925 5mg Medchemexpress, BI-749327 CAS: Purity:>98%
SDP

Medchemexpress, HY-111925 5mg BI-749327 CAS: BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC 50 s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7 [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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9

Medchemexpress LLC CSK-IN-1 | 2380027-49-4 | 98.6% | 50 MG
SDP

CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) inhibitor with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. It increases T cell proliferation induced by T cell receptor signaling. This product is for research use only.

  • Potent, orally active c-terminal Src kinase (CSK) inhibitor
  • Achieves IC50 values below 3 nM in CSK HTRF assay
  • Achieves IC50 values below 4 nM in Caliper assay
  • Increases T cell proliferation induced by T cell receptor signaling
  • Reduces inhibitory LCK phosphorylation in vivo upon oral dosing
  • Enhances T cell activation in response to antigen stimulation
  • Shows EC50 of 41 nM on ZAP70 phosphorylation in human Jurkat cells

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