Aminophenols
Medchemexpress LLC Quercetagitrin | 548-75-4 | 50 MG
Quercetagitrin, a natural product from African marigold, exhibits anti-inflammatory activity. It shows promise in neuroscience research by inhibiting Tau accumulation, reversing neuroinflammation, and improving cognitive function in P301S-Tau transgenic mouse models. This compound also acts as a dual-target inhibitor of PTPN6 and PTPN9, enhancing glucose uptake in C2C12 myoblasts, making it a relevant agent for studies in Alzheimer's disease and type 2 diabetes.
- Exhibits anti-inflammatory activity.
- Inhibits Tau accumulation and reverses neuroinflammation.
- Acts as a dual-target inhibitor of PTPN6 and PTPN9.
- Enhances glucose uptake and mitigates insulin resistance in C2C12 myoblasts.
- Attenuates synaptic impairments and cognitive deficits in P301S-Tau transgenic mice.
- Reduces tau accumulation and gliosis.
- Applicable for research in Alzheimer's disease and type 2 diabetes.
Medchemexpress LLC NS8593 (hydrochloride) | 875755-24-1 | 99.8% | 299.80 | 25 MG
NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels). It reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. It also inhibits SK1-3 subtypes in a Ca2+-dependent manner (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), but it does not affect intermediate and large conductance Ca2+-activated K+ channels (hIK and hBK channels).
- Potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor.
- Reversibly inhibits SK3-mediated currents.
- Active on apamin-insensitive SK3 channels.
- Affects firing rate and pattern of dopaminergic neurons in vivo.
eMolecules Key Organics/BIONET Medetomidine Hydrochloride 7mg 564356416 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Key Organics/BIONET Medetomidine Hydrochloride 7mg 564356416 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Medchemexpress LLC MRL-494 (hydrochloride) | 2699937-04-5 | 98.6% | 25 MG
MRL-494 hydrochloride is an antibacterial agent that acts as an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, effectively inhibiting both Gram-positive and Gram-negative bacteria. The agent lethally disrupts the cytoplasmic membrane and inhibits outer membrane protein biogenesis by targeting BamA.
- Impervious to efflux and outer membrane permeability barrier
- Inhibits both Gram-positive and Gram-negative bacteria
- Lethally disrupts cytoplasmic membrane
- Inhibits outer membrane protein biogenesis
TARGETMOL CHEMICALS INC FMK 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. FMK is an irreversible inhibitor of RSK2 kinase. purity: 98%
eMolecules 3-Chloro-N-(3-hydroxyphenyl)-2,2-dimethylpropanamide | 303986-05-2 | MFCD00793397 | 100mg
Oakwood Chemical | 3-Chloro-N-(3-hydroxyphenyl)-2,2-dimethylpropanamide | 100mg | 537712736 | 181182 | | 303986-05-2 | MFCD00793397 | 227.690 | C11H14ClNO2
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Medchemexpress LLC RGX-104 hydrochloride | 610318-03-1 | 99.9% | 632.54 | 10 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity through the transcriptional activation of the ApoE gene. It is intended for research use only.
- Modulates innate immunity via transcriptional activation of the ApoE gene.
- Potential anti-cancer activity through suppression of various cancer types, including lung cancer, melanoma, glioblastoma, ovarian, renal cell, triple-negative breast, and colon cancer.
- Induces tumor regression in some cases.
- Available in various quantities.
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 100 MG
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. It shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/β-arrestin-2 interactions. It demonstrates antipsychotic-like activity. It is for research use only.
- Functions as a β-arrestin-biased dopamine D2 receptor agonist.
- Selectively activates β-arrestin recruitment and signaling.
- Exhibits a binding affinity (Ki) of 79 nM for D2R.
- Acts as an antagonist of Gi-regulated cAMP production.
- Serves as a partial agonist for D2R/β-arrestin-2 interactions.
- Demonstrates antipsychotic-like activity.
Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 25 MG
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication by binding to the EV71 SLII domain with moderately high affinity (KD= 520 nM). It induces conformational changes in RNA structure, stabilizing the ternary complex DMA135-RNA-AUF1, thereby inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM. Cell-based studies indicate no significant toxicity.
- Inhibits enterovirus 71 (EV71) IRES-dependent translation
- Inhibits enterovirus 71 (EV71) replication
- Binds to EV71 SLII domain with moderately high affinity (KD= 520 nM)
- Induces conformational changes in RNA structure
- Stabilizes the ternary complex DMA135-RNA-AUF1
- No significant toxicity in cell-based studies