Aminophenols
Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.9% | 394.86 | 100 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction and does not interact with Cdc42 or Rac1. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific RhoA subfamily Rho GTPases inhibitor
- Induces cell apoptosis
- Promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability
- Dose-dependently reduces RhoA and p-MLC1 activities of mammospheres
- Decreases size and reduces number of mammospheres in cells
- Prevents social avoidance and blocks sucrose preference deficits in mice
- Attenuates stress-induced social avoidance
- Blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs)
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 1 ML
Guvacine hydrochloride is a GABA transporter inhibitor used in neuroscience research to investigate GABAergic signaling and transporter pharmacology. It is supplied with documented purity, molecular data, and recommended storage conditions to support reliable in vitro experiments.
- Inhibits GABA transporter activity with reported IC50 values for multiple transporter subtypes.
- Supplied as a ready-to-use 10 mM solution in DMSO (1 ML) for immediate use in assays.
- Also available as a solid for custom preparation and long-term storage.
- High reported purity supports reproducible experimental results.
- Storage guidance provided to maintain stability of solid and solution forms.
Medchemexpress LLC Harmine hydrochloride | 343-27-1 | MFCD00078028 | 248.71 | 1 ML
Harmine hydrochloride, also known as Telepathine hydrochloride, is a natural DYRK inhibitor. It exhibits anticancer and anti-inflammatory activities, and has a high affinity for the 5-HT2A serotonin receptor. It is supplied as a solution in DMSO.
- Natural DYRK inhibitor
- Exhibits anticancer and anti-inflammatory activities
- High affinity for 5-HT2A serotonin receptor
- Supplied in solution for convenience
Cayman Chemical N-acetyl-2-AmInophenol 250g
A derivative of acetaminophen; inhibits ADP- or arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 50 µM; decreases disease severity and prevents increases in paw volume in a rat model of collagen-induced arthritis at 1 mg/kg; has been used as a synthetic intermediate in the synthesis of compounds with antimalarial activity; a potential impurity in commercial preparations of acetaminophen
Medchemexpress LLC Afm32a hydrochloride | 2988594-85-8 | 99.7% | 517.00 g/mol | C25H30ClFN6O3 | 5 MG
AFM32a hydrochloride is a benzimidazole-derived small-molecule inhibitor selective for protein arginine deiminase 2 (PAD2). Supplied as the hydrochloride salt for research use, it is suitable for biochemical assays and target validation, demonstrating approximately 95-fold selectivity for PAD2 versus PAD4 and 79-fold versus PAD3.
- Potent PAD2 inhibition with high selectivity over PAD3 and PAD4.
- Hydrochloride salt form for improved solubility and handling.
- High purity (≈99.7%) appropriate for biochemical assays.
- Available in small-mass and DMSO solution formats for screening.
- Characterized with molecular formula and molecular weight for analytical use.
Medchemexpress LLC MELK-8a hydrochloride | 2096992-20-8 | 99.3% | 469.02 g/mol | C25H33ClN6O | 25 MG
MELK-8a hydrochloride is a potent small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK) with a reported IC50 of 2 nM. Supplied as the hydrochloride salt with high chemical purity, it is intended for research use in biochemical and cellular studies targeting MELK-dependent pathways.
- Potent MELK inhibition with an IC50 of 2 nM.
- Hydrochloride salt for improved stability and handling.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 469.02 g/mol and formula C25H33ClN6O.
- Soluble in DMSO; solution formats available for convenient dosing.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Zzw-115 hydrochloride | 10122-45-9 | 98.1 % | 573.97 | 5 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity. It is efficient in killing various cancer cells with IC50 values ranging from 0.42 μM to 4.93 μM. This compound also induces a decrease in ATP production and a ROS overproduction.
- Efficient in killing cancer cells with IC50 values ranging from 0.42 μM to 7.75 μM
- Induces tumor cell death via necroptosis and apoptosis
- Decreases ATP production and induces ROS overproduction
- Inhibits the growth of pancreatic xenografted tumors in vivo
- Demonstrates potent anticancer activity
eMolecules 161265-03-8 | Xantphos | Ambeed | MFCD00233866 | 578.632 | C39H32OP2 | 98.000 | CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(cccc12)P(c1ccccc1)c1ccccc1 | 1000g | 801040986
Xantphos | Ambeed | 161265-03-8 | MFCD00233866 | 578.632 | C39H32OP2 | 98.000 | CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(cccc12)P(c1ccccc1)c1ccccc1 | 1000g | 801040986
Medchemexpress LLC 4-fluorobenzaldehyde | 459-57-4 | MFCD00003378 | 97.3% | 124.11 | C7H5FO | 1000g
4-Fluorobenzaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Accela Chembio Inc 3-amino-5-hydroxybenzoic Acid Hydrochloride | 5g | 14206-69-0 | MFCD00043420 | 97+% | Shelf Life: 1620 Days | Light Sensitive/moisture Sensitive
3-amino-5-hydroxybenzoic Acid Hydrochloride | 5g | 14206-69-0 | MFCD00043420 | 97+% | Shelf Life: 1620 Days | Light Sensitive/moisture Sensitive
eMolecules 29684-56-8 | Burgess reagent | Ambeed | MFCD00077815 | 238.300 | C8H18N2O4S | 95.000 | CC[N+](CC)(CC)S(=O)(=O)[N-]C(=O)OC | 1000g | 716948098
Burgess reagent | Ambeed | 29684-56-8 | MFCD00077815 | 238.300 | C8H18N2O4S | 95.000 | CC[N+](CC)(CC)S(=O)(=O)[N-]C(=O)OC | 1000g | 716948098
Apexbio Technology LLC XMD8-92 1234480-50-2 10mM (in 1mL DMSO)
XMD8-92 (CAS 1234480-50-2) is a potent small-molecule inhibitor of mitogen-activated protein kinase 7 (MAPK7/BMK1) demonstrating a Kd of 80 nM and inhibiting EGF-induced BMK1 activation with an IC50 of 240 nM In cellular studies XMD8-92 suppresses proliferation and tumor xenograft growth of cancer cell lines linked to upregulation of tumor-suppressive miRNAs and downregulation of DCLK1 and several oncogenic targets In murine models it impedes the progression of lung and cervical cancer xenografts primarily by affecting cell cycle regulation and angiogenesis XMD8-92 remains under preclinical investigation for its potential in cancer research
Aobchem 1-Bromo-3 5-difluoro-2 4-dimethoxybenzene | 95% | CAS 2969447-54-7 | C8H7BrF2O2 | 1g
1-Bromo-3 5-difluoro-2 4-dimethoxybenzene | 95% | CAS 2969447-54-7 | C8H7BrF2O2 | 1g
Aobchem 4-Bromo-N-(2-hydroxy-1 1-dimethylethyl)benzenesulfonamide | 95% | CAS 502484-72-2 | C10H14BrNO3S | 500mg
4-Bromo-N-(2-hydroxy-1 1-dimethylethyl)benzenesulfonamide | 95% | CAS 502484-72-2 | C10H14BrNO3S | 500mg