Aminophenols
Medchemexpress LLC HY-117288 10mg Medchemexpress, S55746 CAS:1448584-12-0 Purity:>98%
Medchemexpress, HY-117288 10mg S55746 CAS:1448584-12-0 S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Dimedone (5,5-dimethylcyclohexane-1,3-dione) | 126-81-8 | MFCD00001588 | 99.7% | 140.18 g/mol | C8H12O2 | 1000 G
Dimedone (5,5-dimethylcyclohexane-1,3-dione) is a small-molecule biochemical reagent used in laboratory research. It is a cyclic diketone (CAS 126-81-8) with formula C8H12O2 and molecular weight 140.18 g/mol. The material is supplied for research use only and is provided at high stated purity.
- High purity (99.7%).
- CAS number 126-81-8.
- Chemical formula C8H12O2.
- Molecular weight 140.18 g/mol.
- Soluble in DMSO.
- Available in multiple bulk pack sizes for laboratory use.
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 2 MG
SR9011 hydrochloride is a potent REV-ERBα/β agonist (IC50s: 790 nM for REV-ERBα, 560 nM for REV-ERBβ). It significantly increases REV-ERB-dependent repressor activity and suppresses transcription via full-length REV-ERBα. The compound inhibits BMAL1 mRNA expression in HepG2 cells and suppresses breast cancer cell proliferation by halting the cell cycle before M phase. In mice, SR9011 suppresses REV-ERB responsive genes and temporarily reduces locomotor activity during the dark phase.
- Potent REV-ERBα/β agonist.
- Increases REV-ERB-dependent repressor activity.
- Suppresses transcription via full-length REV-ERBα.
- Inhibits BMAL1 mRNA expression in HepG2 cells.
- Suppresses breast cancer cell proliferation.
- Pauses cell cycle prior to M phase, increasing G0/G1 phase cells.
- Suppresses REV-ERB responsive genes in mice.
- Reduces locomotor activity in mice under dark conditions.
Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 1 ML
ZLN024 hydrochloride is an allosteric activator of AMPK, directly stimulating active AMPK heterotrimers as well as inactive α1 subunit truncations. This activation requires pre-phosphorylation of Thr-172 by upstream kinases and protects AMPK Thr-172 from dephosphorylation. It activates AMPK in L6 myotubes, promoting glucose uptake and fatty acid oxidation without altering the ADP/ATP ratio. In vivo studies showed improved glucose tolerance and reduced fasting blood glucose in C57BKS db/db mice.
- Allosterically stimulates active AMPK heterotrimers.
- Activates AMPK in L6 myotubes.
- Stimulates glucose uptake and fatty acid oxidation.
- Improves glucose tolerance.
- Reduces fasting blood glucose.
Medchemexpress LLC Tecalcet hydrochloride | 177172-49-5 | MFCD16038895 | 99.7% | 340.29 g/mol | C18H23Cl2NO | 1 ML
Tecalcet hydrochloride is an orally active calcimimetic that allosterically and positively modulates the calcium-sensing receptor (CaSR). It is provided for research use in solution and solid forms and is commonly used in in vitro pharmacology and calcium-signaling studies.
- Orally active calcimimetic that modulates the calcium-sensing receptor.
- Suitable for in vitro pharmacology and CaSR signaling studies.
- Available as a 10 mM solution in DMSO (1 mL) and as solid quantities for formulation flexibility.
- High chemical purity (≈99.7%) for reliable experimental results.
- Molecular weight 340.29 g/mol and molecular formula C18H23Cl2NO.
Medchemexpress LLC P-amidinophenylmethylsulfonylfluoride hydrochloride | 74938-88-8 | MFCD00078902 | 95.0% | 252.69 | C8H10ClFN2O2S | 1 MG
p-APMSF hydrochloride is the hydrochloride salt of p-amidinophenylmethylsulfonylfluoride, an irreversible serine protease inhibitor selective for substrates with positively charged side chains such as lysine and arginine. It is provided as a high-purity research reagent for enzymology and biochemical assays.
- Irreversible serine protease inhibitor selective for positively charged side chains.
- Provided as the hydrochloride salt to aid solubility in aqueous assays.
- High purity (95.0%) suitable for research and assay development.
- Molecular weight 252.69; formula C8H10ClFN2O2S.
- Offered in small-scale packaging (1 mg) for screening and mechanistic studies.
Apexbio Technology LLC MOG (35-55) 149635-73-4 1mg
MOG (35-55) (CAS 149635-73-4) is a truncated peptide derived from human myelin oligodendrocyte glycoprotein (MOG) MOG an immunoglobulin superfamily glycoprotein specifically expressed in the central nervous system serves as a target antigen in experimental autoimmune encephalomyelitis (EAE) an animal model resembling multiple sclerosis (MS) The MOG (35-55) peptide induces strong inflammatory responses via activation of autoreactive T cells and promotion of autoantibody production leading to extensive demyelination Due to its prominent encephalitogenic properties it is widely utilized in preclinical research for studying MS pathogenesis and therapeutic interventions
Medchemexpress LLC G-5555 hydrochloride | 2319590-15-1 | 98.3% | 529.42 | 1 ML
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
- Excellent kinase selectivity, inhibiting only eight out of 235 kinases tested (>70% inhibition).
- High selectivity for group I PAKs.
- Negligible activity against the hERG channel (IC50 > 10 μM).
- Exhibits significantly greater growth inhibitory activity in PAK-amplified breast cancer cell lines.
- Low blood clearance and acceptable half-life in vivo.
- Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) in vivo.
- Inhibits phosphorylation of MEK1 S298 and shows 60% tumor growth inhibition in xenograft models.
TARGETMOL CHEMICALS INC ABT530 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. ABT530 (Pibrentasvir) is an HCV NS5A inhibitor with EC50s ranging from 1.4-5.0 pM against HCV replicons containing NS5A from genotypes 1-6. purity: 99%