Cresols
Selleck Chemical LLC 2OH-BNPP1 S3522-25mg
2OH-BNPP1 is an inhibitor of the kinase activity of BUB1 (budding uninhibited by benzimidazoles-1 BUB1 Mitotic Checkpoint Serine/Threonine Kinase) that can be used for the treatment of cancer
Apexbio Technology LLC EZ Cap Mouse IL-23α mRNA (m1Ψ HA tag) 5x1mg (1mg/mL)
Mouse IL-23 mRNA encodes a subunit of interleukin-23 (IL-23) IL-23 has two subunits p19 (IL-23 ) and p40 IL-23 binds p40 to form a functional cytokine promoting differentiation and maintenance of Th17 cells which are essential in anti-microbial defense and autoimmune diseases Dysregulated expression of IL-23 is associated with multiple inflammatory diseases such as psoriasis Crohn s disease and multiple sclerosis IL-23 and its subunit IL-23 are therapeutic targets for these diseases and numerous biologics have been developed to inhibit their activity EZ Cap Mouse IL-23 mRNA (m1 HA tag) is provided at 1 mg/mL encoding mouse IL-23 cytokine fused with an HA tag enabling convenient downstream detection of expressed proteins With cap 1 structure generated through co-transcriptional capping incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vi
Apexbio Technology LLC EZ Cap Mouse CD86 mRNA (m1Ψ HA tag) 100ug (1mg/mL)
Mouse CD86 mRNA encodes CD86P primarily expressed on antigen-presenting cells It binds to CD28 and CTLA-4 receptors on T cells to regulate T-cell activation and immune responses The interaction between CD86 and CD28 promotes T-cell activation and proliferation whereas its binding to CTLA-4 inhibits T-cell activity maintaining immune system balance Expression and function of CD86 are critical in various immune responses including infections tumor immunity and autoimmune diseases CD86 activity may offer novel therapeutic strategies for various immune-related disorders EZ Cap Mouse CD86 mRNA (m1 HA tag) is provided at 1 mg/mL expressing mouse-derived CD86 cytokine fused with HA tag facilitating subsequent detection It contains a cap 1 structure generated via co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Apexbio Technology LLC EZ Cap Mouse CD80 mRNA (m1Ψ HA tag) 1mg (1mg/mL)
Mouse CD80 mRNA encodes CD80P Binding to CD28 and CTLA-4 receptors on T cells CD80 modulates T-cell activation and inhibition CD80 interacting with CD28 promotes T-cell activation and proliferation enhancing immune responses Its binding to CTLA-4 provides inhibitory signals maintaining immune tolerance and preventing excessive immune reactions CD80 have emerged as therapeutic targets in various immunotherapies such as treatments for autoimmune diseases transplantation rejection and cancer immunotherapy EZ Cap Mouse CD80 mRNA (m1 HA tag) is provided at 1 mg/mL and expresses mouse CD86 cytokine fused with an HA tag facilitating subsequent detection It contains a cap 1 structure generated via co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Apexbio Technology LLC EZ Cap Mouse IL-12 mRNA (m1Ψ) 100ug (1mg/mL)
Mouse IL-12 mRNA encodes a cytokine Interleukin-12 secreted by antigen-presenting cells such as dendritic cells macrophages and B cells It promotes the activation and proliferation of T cells and natural killer (NK) cells thus enhancing the body s immune response IL-12 induces the differentiation of T cells into Th1 cells thereby enhancing cell-mediated immunity and increasing the production of interferon- (IFN- ) crucial for antiviral and antitumor immune responses EZ Cap Mouse IL-12 mRNA (m1 ) is provided at 1 mg/mL encoding mouse IL-12 cytokine It contains a cap 1 structure generated through co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Apexbio Technology LLC EZ Cap Mouse CD137 mRNA (m1Ψ HA tag) 100ug (1mg/mL)
Mouse CD137 mRNA encodes CD137P(4-1BB) mainly expressed on activated T cells natural killer (NK) cells and dendritic cells The ligand for CD137 is 4-1BBL primarily expressed on antigen-presenting cells Activation of CD137 enhances T-cell proliferation and survival and promotes the secretion of cytokines such as IFN- and IL-2 thereby strengthening immune responses Activating CD137 can enhance anti-tumor immune responses CD137 signaling pathways play complex roles in autoimmune diseases and transplant rejection EZ Cap Mouse CD137 mRNA (m1 HA tag) supplied at 1 mg/mL encodes mouse-derived CD137 cytokine fused to HA tag facilitating subsequent protein expression detection It contains a cap 1 structure generated through co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Selleck Chemical LLC Lac-Phe-E1263-25MG
N-Lactoyl-Phenylalanine (Lac-Phe) is a blood-borne signalling metabolite induced upon exercise
Cayman Chemical 2-Methoxy-4-methylphenol 250g
An active metabolite of oxybutynin binds to mAChRs in isolated rat bladder submaxillary gland heart and colon (Kis 5 38 3 12 16 and 5 59 nM respectively) reduces micturition pressure in rats at 0 4 and 0 8 mg/kg