Cresols
MEDCHEMEXPRESS LLC m-PEG4-CH2-acid | 874208-84-1 | C11H22O6 | 100 MG
m-PEG4-CH2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets a specific protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
MEDCHEMEXPRESS LLC M-PEG12-azide | 2170098-29-8 | >98.6% | C25H51N3O12 | 5 G
m-PEG12-azide is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates various conjugation reactions.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent with an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
MEDCHEMEXPRESS LLC 3-(2-Pyridyldithio)propanoic Acid | 68617-64-1 | 99.5% | 25 G
3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting two ligands: one for an E3 ubiquitin ligase and another for the target protein.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes the ubiquitin-proteasome system
- Selectively degrades target proteins
MEDCHEMEXPRESS LLC R-1 Methanandamide Phosphate | 649569-33-5 | 98.0% | 1 ML
R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA), an endogenous cannabinoid compound. It is intended for research use only and not for patient use.
- Water-soluble prodrug analog of arachidonylethanolamide (AEA)
- Endogenous cannabinoid compound
- Appears as a viscous liquid
- Yellow to brown color
- For research use only
- Store at -20°C, protected from light
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
MEDCHEMEXPRESS LLC m-PEG7-CH2CH2COOH | 1093647-41-6 | >99.39% | 25 G
m-PEG7-CH2CH2COOH (CAS No. 1093647-41-6) is a non-cleavable, PEG-based linker used in the synthesis of antibody-drug conjugates (ADCs) and as a PROTAC linker. It is an essential component for developing targeted therapeutics due to its role in connecting active pharmaceutical ingredients to targeting moieties.
- Recommended storage for pure form: -20°C for 3 years, 4°C for 2 years.
- Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month.
- Shipping at room temperature is acceptable if duration is less than 2 weeks.
- Chemically identified as 4,7,10,13,16,19,22,25-Octaoxahexacosanoic acid.
MEDCHEMEXPRESS LLC N-(p-Coumaroyl) Serotonin | 68573-24-0 | 99.0% | 25 MG
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2, and caspase-8 with antioxidant, anti-atherosclerotic, and anti-inflammatory properties. It inhibits glioblastoma cells (U251MG, T98G) and normal fibroblasts. This compound inhibits PDGF signaling by reducing receptor phosphorylation, blocks Ca2+ influx, and induces apoptosis by activating caspase-8. It may improve atherosclerosis and aortic wall enlargement, and is also used in the study of glioblastoma.
- Selective inhibitor of PDGFRβ, ERK1/2, and caspase-8
- Possesses antioxidant, anti-atherosclerotic, and anti-inflammatory properties
- Inhibits glioblastoma cell growth
- Inhibits PDGF signaling by reducing receptor phosphorylation
- Blocks Ca2+ influx and induces apoptosis
- May improve atherosclerosis and aortic wall enlargement
MEDCHEMEXPRESS LLC N-(p-Coumaroyl) Serotonin | 68573-24-0 | 99.0% | 10 MG
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2, and caspase-8, exhibiting antioxidant, anti-atherosclerotic, and anti-inflammatory properties. It inhibits glioblastoma cells and can improve atherosclerosis and aortic wall enlargement.
- Selective inhibitor of PDGFRβ, ERK1/2, and caspase-8
- Exhibits antioxidant, anti-atherosclerotic, and anti-inflammatory properties
- Inhibits glioblastoma cells
- Blocks calcium influx
- Induces apoptosis by activating caspase-8
- Can improve atherosclerosis and aortic wall enlargement
- Used in glioblastoma research
MEDCHEMEXPRESS LLC N-(p-Coumaroyl) Serotonin | 68573-24-0 | 99.0% | 1 ML
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2, and caspase-8, possessing antioxidant, anti-atherosclerotic, and anti-inflammatory properties. This compound inhibits glioblastoma cells and has the potential to improve atherosclerosis and aortic wall enlargement. It is for research use only.
- Selective inhibitor of PDGFRβ, ERK1/2, and caspase-8
- Possesses antioxidant, anti-atherosclerotic, and anti-inflammatory properties
- Inhibits glioblastoma cells (U251MG, T98G) with IC50 values ranging from 48-81 μM
- Works by inhibiting PDGF signaling, blocking Ca2+ influx, and inducing apoptosis
- Potential to improve atherosclerosis and aortic wall enlargement
- Useful in glioblastoma research
MEDCHEMEXPRESS LLC 4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- | 901398-68-3 | 99.05% | 364.44 | 10 MG
PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor. It is suitable for research applications, particularly in studies involving PI3Kbeta-mediated Akt phosphorylation and mTORC2-mediated Akt phosphorylation.
- Inhibits human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue with an IC50 of 3 nM.
- Inhibits human PI3Kbeta-mediated Akt phosphorylation at T308 residue with an IC50 of 3 nM.
- Inhibits mTORC2-mediated Akt phosphorylation at Ser473 residue with an IC50 of 3 nM.
- Blocks phosphorylation of PKB/Akt at concentrations of 0.1-10 μM.
- Soluble in DMSO at 50 mg/mL.
- Clear solution with 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline at ≥ 2.08 mg/mL.
- Clear solution with 10% DMSO, 90% (20% SBE-β-CD in Saline) at ≥ 2.08 mg/mL.
- Clear solution with 10% DMSO, 90% Corn Oil at ≥ 2.08 mg/mL.
MEDCHEMEXPRESS LLC Potassium p-nitrophenyl sulfate | 6217-68-1 | 99.9% | 257.26 | 5 G
Potassium p-nitrophenyl sulfate is a chromogenic substrate for arylsulfatase. It is released by arylsulfonase cleavage, allowing for the quantitative determination of arylsulfonase activity through colorimetric detection at 400 nm.
- Chromogenic substrate for arylsulfatase
- Activity can be quantitatively determined by colorimetric detection at 400 nm
- Appearance: Solid
- Color: Off-white to yellow
- Shipping at room temperature in continental US
- Storage at 4°C, sealed, away from moisture and light
- In solvent storage: -80°C for 6 months; -20°C for 1 month
MEDCHEMEXPRESS LLC P-CAB agent 2 | 1978371-23-1 | C22H25FN2O4S | 50 MG
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. It inhibits H+/K+-ATPase activity and the hERG potassium channel. This agent shows no acute toxicity and inhibits histamine-induced gastric acid secretion.
- Potent and orally active potassium-competitive acid blocker
- Gastric acid secretion inhibitor
- Inhibits H+/K+-ATPase activity with an IC50 value of <100 nM
- Inhibits the hERG potassium channel with an IC50 value of 18.69 μM
- Shows no acute toxicity
- Inhibits histamine-induced gastric acid secretion
MEDCHEMEXPRESS LLC P-CAB agent 2 (hydrochloride) | 2209911-80-6 | C22H26ClFN2O4S | 50 MG
P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. It inhibits H+/K+-ATPase activity with an IC50 value of <100 nM and the hERG potassium channel with an IC50 value of 18.69 μM. This compound shows no acute toxicity and inhibits histamine-induced gastric acid secretion.
- Potent and orally active potassium-competitive acid blocker
- Gastric acid secretion inhibitor
- Inhibits H+/K+-ATPase activity with an IC50 value of <100 nM
- Inhibits hERG potassium channel with an IC50 value of 18.69 μM
- Shows no acute toxicity
- Inhibits histamine-induced gastric acid secretion