Cresols

Organic compounds that consist of a phenol ring with a methyl functional group substitution; also called methylphenols and hydroxytoluenes.

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Apexbio Technology LLC P 22077 1247819-59-5 10mg

P 22077 (CAS 1247819-59-5) is a small molecule inhibitor targeting ubiquitin-specific protease 7 (USP7 also known as HAUSP) and to a lesser extent deubiquitinase USP4 USP7 modulates the stability of several regulatory proteins including p53 impacting apoptosis pathways in cancer biology P 22077 demonstrates potent USP7 inhibition with IC values of 8 6 nM in singleplex and 7 8 nM in multiplex in vitro assays and shows minimal activity against related enzymes DEN1 and SENP2core Cellular studies suggest that P 22077-mediated USP7 inhibition destabilizes Tip60 attenuating p53-dependent apoptosis The compound is currently utilized in preclinical research investigating the role of deubiquitination in tumorigenesis

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Apexbio Technology LLC P 22077 1247819-59-5 50mg

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Medchemexpress LLC P 22077 | 1247819-59-5 | 98.42% | 315.32 | 100 MG

P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor, also inhibiting USP47. It causes DUBs inhibition in HEK293T cells and significantly reduces the viability of Neuroblastoma (NB) cells. P 22077 increases p53 activity, inducing apoptosis in p53 wild-type and HDM2-expressing NB cells, and enhances the cytotoxic effects of Dox and VP-16. In vivo, it exhibits potent antitumor activities in xenograft mouse models.

Cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor
Also inhibits USP47
Reduces neuroblastoma cell viability
Increases p53 activity and induces apoptosis
Enhances Dox and VP-16 cytotoxic effects
Demonstrates potent antitumor activities in mouse models

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Medchemexpress LLC P 22077 | 1247819-59-5 | 98.4% | 315.32 | 50 MG

P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. It also inhibits USP47 with an EC50 of 8.74 μM.

USP7 inhibitor (EC50: 8.01 μM)
USP47 inhibitor (EC50: 8.74 μM)
Cell-permeable
Inhibits a smaller subset of DUBs at 15-45 μM
Causes DUBs inhibition in HEK293T cells at 25 μM
Greatly reduces cell viability of neuroblastoma (NB) cells
Increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells at 10 μM
Enhances cytotoxic effect of Dox and VP-16 on NB cells, and enhances Dox- and VP-16-induced p53-mediated apoptosis at 5 μM
Shows potent antitumor activities in xenograft mouse models bearing IMR-32-derived tumors
Exhibits antitumor effects in mice bearing SH-SY5Y-derived tumors and NGP-derived tumors

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Medchemexpress LLC P 22077 | 1247819-59-5 | 98.42% | 315.32 | 10 MG

P 22077 is a cell-permeable inhibitor targeting ubiquitin-specific protease 7 (USP7) with an EC50 of 8.01 μM, and USP47 with an EC50 of 8.74 μM. This compound demonstrates antiproliferative activity against human HCT116 cells and induces p53-mediated apoptosis in neuroblastoma cells, highlighting its potential for anticancer research.

Cell-permeable USP7 and USP47 inhibitor
Inhibits USP7 with an EC50 of 8.01 μM
Inhibits USP47 with an EC50 of 8.74 μM
Shows antiproliferative activity against human HCT116 cells
Induces p53-mediated apoptosis in neuroblastoma cells
Exhibits antitumor effects in xenograft mouse models

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Apexbio Technology LLC P 22077 1247819-59-5 10mM (in 1mL DMSO)

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Medchemexpress LLC Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]- | 1247819-59-5 | 98.4% | 315.32 | 25 MG

P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor that also inhibits USP47. It demonstrates antiproliferative activity against human HCT116 cells and reduces the viability of neuroblastoma cells. The compound increases p53 activity, induces apoptosis in p53 wild-type and HDM2-expressing neuroblastoma cells, and enhances the cytotoxic effects of Dox and VP-16. In vivo, it exhibits potent antitumor activities in xenograft mouse models.

Cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor
Inhibits USP47
Exhibits antiproliferative activity against human HCT116 cells
Reduces cell viability of neuroblastoma cells
Increases p53 activity and induces apoptosis in p53 wild-type cells
Enhances cytotoxic effect of Dox and VP-16 on neuroblastoma cells
Shows potent antitumor activities in xenograft mouse models

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Medchemexpress LLC 1-[5-(2,4-difluorophenyl)sulfanyl-4-nitrothiophen-2-yl]ethanone | 1247819-59-5 | MFCD22580421 | ≥98.0% | 315.32 g·mol-1 | C12H7F2NO3S2 | 5 MG

A cell-permeable small-molecule inhibitor of the deubiquitinating enzyme ubiquitin-specific protease 7 (USP7) that also inhibits USP47. It is used in biochemical and cell-based studies to probe deubiquitination pathways; reported EC50 values are 8.01 μM for USP7 and 8.74 μM for USP47. Molecular formula C12H7F2NO3S2; molecular weight 315.32 g·mol-1; CAS 1247819-59-5.

Cell-permeable small-molecule inhibitor of USP7 and USP47 (EC50 8.01 μM and 8.74 μM).
Suitable for biochemical and cell-based deubiquitination assays.
Reported activity values support use in target validation and pathway studies.
Provided in small research quantities for laboratory experiments (1-10 mg).
Molecular formula C12H7F2NO3S2 and molecular weight 315.32 g·mol-1.

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