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Filtered Search Results
Apexbio Technology LLC Methenamine 10mM (in 1mL DMSO)
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B1972 is a small molecule designed for biomedical research applications It modulates specific cellular signaling pathways thereby influencing target protein function at the molecular level B1972 has been utilized in studies investigating pathway regulation cell proliferation and disease models where pathway dysregulation occurs Its application enables the elucidation of signaling mechanisms and supports the development of targeted therapeutic strategies in preclinical research contexts
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Medchemexpress LLC Tropine | 120-29-6 | 250 G
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Tropine is a tropane alkaloid that serves as an important intermediate for the synthesis of anticholinergics and bronchodilators such as Atropine and Scopolamine. It is intended for research and analytical applications.
- Molecular formula: C8H15NO
- Molecular weight: 141.21
- Purity: 99.26% (GC)
- Appearance: White to light yellow solid
- Target: Drug intermediate
- Powder storage: -20°C for 3 years; 4°C for 2 years
- In solvent storage: -80°C for 6 months; -20°C for 1 month
- Solubility in DMSO: 100 mg/mL
- Solubility in H₂O: 50 mg/mL
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Medchemexpress LLC Acriflavine hydrochloride | 69235-50-3 | 99.4% | 541.90 | 500 MG
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Acriflavine hydrochloride | 69235-50-3 | 99.4% | 541.90 | 500 MG
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Medchemexpress LLC Norverapamil (hydrochloride) | 67812-42-4 | MFCD00078605 | 99.8% | 477.04 g/mol | C26H37ClN2O4 | 1 ML
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Norverapamil hydrochloride is the N-demethylated major metabolite of verapamil that functions as an L-type calcium channel blocker and a P-glycoprotein (P-gp) inhibitor. It is provided for research use and is supplied as a white to off-white solid or as a pre-made 10 mM solution in DMSO for laboratory assays and in vivo studies.
- High purity suitable for research applications.
- Available as solid and as a 10 mM stock solution in DMSO.
- Soluble in water and DMSO; stock preparation examples provided.
- Storage recommendations for solids and solutions to preserve stability.
- Useful for calcium channel pharmacology and P-gp transporter studies.
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Apexbio Technology LLC HyperTrap SP HP Column 5ml
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HyperTrap SP HP Column is a chromatography medium designed for the efficient purification of biomolecules based on strong cation exchange principles The column utilizes sulfopropyl (SP) ligands immobilized on a high-performance matrix allowing selective binding of positively charged proteins and peptides under controlled buffer conditions This mechanism facilitates the separation and enrichment of target analytes from complex biological samples The HyperTrap SP HP Column is commonly applied in protein purification workflows biomarker discovery and quality control assays within biomedical research
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![eMolecules 303752-38-7 | 3-(tert-butoxycarbonylamino)bicyclo[1.1.1]pentane-1-carboxylic acid | Pharmablock | MFCD09971715 | 227.260 | C11H17NO4 | 97.000 | CC(C)(C)OC(=O)NC12CC(C1)(C2)C(O)=O | 50g | 551080611](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000158471.jpg-250.jpg)
eMolecules 303752-38-7 | 3-(tert-butoxycarbonylamino)bicyclo[1.1.1]pentane-1-carboxylic acid | Pharmablock | MFCD09971715 | 227.260 | C11H17NO4 | 97.000 | CC(C)(C)OC(=O)NC12CC(C1)(C2)C(O)=O | 50g | 551080611
3-(tert-butoxycarbonylamino)bicyclo[1.1.1]pentane-1-carboxylic acid | Pharmablock | 303752-38-7 | MFCD09971715 | 227.260 | C11H17NO4 | 97.000 | CC(C)(C)OC(=O)NC12CC(C1)(C2)C(O)=O | 50g | 551080611
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Aobchem AOBCHEM
5000864959 3-BROMO-6-CHLORO-2-FLUOROPHENO
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Apexbio Technology LLC AS-605240 648450-29-7 10mM (in 1mL DMSO)
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AS-605240 (CAS 648450-29-7) is a cell-permeable small molecule inhibitor selectively targeting class I phosphoinositide 3-kinases (PI3Ks) with pronounced potency against the PI3K isoform (IC50 0 008 M) and lower activity for PI3K / / (IC50 0 06 0 27 and 0 3 M respectively) Structural studies show that AS-605240 binds to PI3K via interactions with Lys-833 and Val-882 It impairs PI3K/Akt signaling as evidenced by inhibition of C5a-induced PKB phosphorylation in RAW264 macrophages In vivo AS-605240 reduces leukocyte migration and suppresses joint inflammation in mouse models of peritonitis and collagen-induced arthritis highlighting its value for investigating PI3K -mediated immune pathways and inflammatory processes
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Apexbio Technology LLC CPI-455 HCl 2095432-28-1 5mg
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CPI-455 HCl (CAS 2095432-28-1) is a potent inhibitor of the KDM5 family of histone demethylases which regulate demethylation of histone H3 lysine 4 (H3K4) CPI-455 exhibits an IC50 of 10 nM for KDM5A in enzymatic assays and displays comparable inhibitory activity against KDM5B and KDM5C but markedly reduced potency for KDM4C and KDM7B and negligible activity towards other KDM family members In vitro CPI-455 treatment leads to a dose-dependent increase in global H3K4me3 levels in HeLa cells with rapid reversal upon compound removal This compound is used in research to probe the role of KDM5-mediated histone modifications and the survival mechanisms of drug-tolerant cancer cell populations
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Ambeed AMBEED
5000867733 3-BROMO-2-METHOXYQUINOLI 100MG
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Apexbio Technology LLC Cinacalcet HCl 364782-34-3 10mM (in 1mL DMSO)
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Cinacalcet HCl (CAS 364782-34-3) is a second-generation calcimimetic that acts as a potent allosteric modulator of the calcium-sensing receptor (CaSR) By enhancing the sensitivity of CaSR to extracellular calcium Cinacalcet HCl suppresses parathyroid hormone (PTH) secretion with an EC50 of 2 8 M reported in in vitro assays In preclinical models such as Rice H-500 tumor-bearing mice oral administration of Cinacalcet HCl significantly reduces blood ionized calcium total serum calcium and PTH-related peptide (PTHrP) levels Its ability to modulate mineral metabolism supports its use in research on disorders involving PTH dysregulation including secondary hyperparathyroidism and related mineral imbalances
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Apexbio Technology LLC AZD-5597 924641-59-8 25mg
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AZD-5597 (CAS 924641-59-8) is an imidazole pyrimidine amide compound that acts as a potent inhibitor of cyclin-dependent kinases CDK1 and CDK2 exhibiting an IC50 of 2 nM for both enzymes CDKs are serine/threonine protein kinases involved in regulation of the cell cycle transcription mRNA processing and neuronal differentiation In cellular studies AZD-5597 demonstrates strong antiproliferative activity such as an MIC50 of 0 039 M in LoVo cells The compound displays high aqueous solubility stability under various conditions and does not inhibit CYP enzymes Preclinical pharmacokinetic evaluations reveal favorable properties supporting its utility as a research tool for investigating CDK inhibition and antitumor activity
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Aobchem AOBCHEM
5000862930 1-BROMO-3- 2-METHYLPROPOXY BEN
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Apexbio Technology LLC Congo Red 573-58-0 10mM (in 1mL DMSO)
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Congo Red (CAS 573-58-0) is a small-molecule inhibitor targeting the vesicular glutamate transporter (VGlut) It is designed to modulate glutamate storage and release thereby influencing synaptic transmission Congo Red exerts its biological activity primarily through selective non-covalent interaction with -sheet-rich structures such as those found in amyloid fibrils Based on these properties Congo Red holds research potential in the detection and qualitative assessment of amyloid deposits in tissue sections characterization of amyloidosis-related samples plant and fungal cell wall amyloids and lipopolysaccharide staining in Gram-negative bacterial outer membranes for biomedical and microbiological studies
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Ambeed AMBEED
5000867382 6-BROMO-3-METHYLBENZODISOX 1GR
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