Halophenols
Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.8% | C49H59ClN8O8S2 | 10MG
OARV-771 is a VHL-based BET degrader (PROTAC) that induces proteasomal degradation of BET family proteins BRD2, BRD3, and BRD4. It demonstrates low-nanomolar degradation potency in cellular assays and is supplied as a solid with high chemical purity for research use.
- Low-nanomolar degradation potency (DC50: Brd2 ~1 nM, Brd3 ~4 nM, Brd4 ~6 nM).
- VHL-based PROTAC mechanism for targeted protein degradation.
- Improved cell permeability for cellular studies.
- High chemical purity suitable for biochemical and cell-based assays.
- Solid form for convenient handling and formulation.
- Recommended sealed cold storage to maintain stability.
Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.8% | C49H59ClN8O8S2 | 50 MG
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3, and shows an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- VHL-based BET degrader (PROTAC)
- Improved cell permeability
- DC50 for Brd4: 6 nM
- DC50 for Brd2: 1 nM
- DC50 for Brd3: 4 nM
- Antiproliferative effect with EC50 of 4 nM in MV4;11 cells
Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.8% | C49H59ClN8O8S2 | 25 MG
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It shows DC50s of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3. It also exhibits an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- VHL-based BET degrader (PROTAC)
- Enhanced cell permeability
- Demonstrates DC50s of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3
- Exhibits an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells
Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59CIN8O8S2 | 100 MG
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- Exhibits DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3.
- Improved cell permeability.
- Shows antiproliferative effect in MV4;11 cells.
Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59ClN8O8S2 | 1 ML
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells. It is for research use only.
- Shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively
- Demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells
- Targets BRD4, BRD2, BRD3, and VHL
Apexbio Technology LLC LL 37(Synonyms: Cathelicidin LL-37, Human Cathelicidin, hCAP-18, CAP18, Antimicrobial peptide LL-37), 1mg, CAS: 154947-66-7.
LL-37 (CAS 154947-66-7) is a naturally occurring antimicrobial peptide derived from human cathelicidin consisting of 37 amino acids with amphipathic structure Its mechanism involves interaction with bacterial membranes resulting in membrane disruption and broad-spectrum antibacterial activity In addition to its antimicrobial role LL-37 modulates immune response contributes to inflammatory regulation and participates in wound healing through influencing cell migration and proliferation Current biomedical research employs LL-37 for investigating infection control immune modulation pathways and tissue repair processes
Medchemexpress LLC Methanone, [2-hydroxy-4-(4-morpholinyl)phenyl]phenyl- | 404009-46-7 | MFCD09037528 | 99.5% | 283.32 g/mol | C17H17NO3 | 1 ML
AMA-37 is an arylmorpholine ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) used for biochemical and cellular research. The compound is provided in both solution and solid formats to support assay work and synthesis.
- Inhibits DNA-PK with IC50 0.27 μM and shows activity against p110α (32 μM), p110β (3.7 μM), and p110γ (22 μM).
- Available as a 10 mM solution in DMSO (1 mL) and in solid vials for scale flexibility.
- CAS number 404009-46-7 for unambiguous chemical identification.
- High reported purity (~99.5%) suitable for research applications.
- Molecular weight 283.32 g/mol for formulation and dosing calculations.
- Appropriate for DNA-PK signaling studies, kinase selectivity profiling, and preclinical assay development.