PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). It binds to MMP-12, forming a PF-00356231/MMP-12 complex. This compound also demonstrates potency against MMP-13, MMP-8, MMP-9, and MMP-3 with IC50 values of 0.00065, 1.7, 0.98, and 0.39 μM, respectively. It is intended for research use only.
- Specific inhibitor of matrix metalloproteinase MMP-12.
- Non-peptidic and non-zinc chelating ligand.
- Potency against MMP-13, MMP-8, MMP-9, and MMP-3.
- Available in solid and solution forms.
- Can be stored at 4°C (sealed, away from moisture) or -80°C/-20°C in solvent.