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Filtered Search Results
Medchemexpress LLC Ro 25-6981 (maleate) | 1312991-76-6 | MFCD06798375 | 99.3% | C26H33NO6 | 10MG
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Ro 25-6981 maleate is a research-grade small molecule that acts as a potent, selective, and activity-dependent antagonist of NR2B (GluN2B)-containing NMDA receptors. It has been used in preclinical studies demonstrating anticonvulsant, anti-parkinsonian, and analgesic effects and is supplied as a white to off-white solid with high purity.
- Potent, selective NR2B NMDA receptor antagonist.
- Demonstrated anticonvulsant and anti-parkinsonian activity in vivo.
- High purity suitable for research applications.
- Supplied as a white to off-white solid for easy handling.
- Stable when stored sealed and protected from moisture.
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Selleck Chemical LLC Ciproxifan Maleate S2813-5mg
Ciproxifan (FUB 359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9 2 nM with low apparent affinity at other receptor subtypes
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eMolecules 6124-79-4 | 4-Methyl-2(5h)-furanone | Combi-Blocks | MFCD00191546 | 98.101 | C5H6O2 | 96.000 | CC1=CC(=O)OC1 | 1g | 267193716
4-Methyl-2(5h)-furanone | Combi-Blocks | 6124-79-4 | MFCD00191546 | 98.101 | C5H6O2 | 96.000 | CC1=CC(=O)OC1 | 1g | 267193716
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Medchemexpress LLC VTP50469 fumarate | 2169919-29-1 | 99.8% | 804.93 g/mol | C32H47FN6O4S · 3/2 C4H4O4 | 5 MG
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VTP50469 fumarate is the fumarate salt of VTP50469, a potent, highly selective, orally active inhibitor of the Menin-MLL (MLL1) protein-protein interaction. It has a reported Ki of 104 pM and demonstrates potent anti-leukemia activity in preclinical studies. The compound is supplied for research use with supporting datasheet, certificate of analysis, and safety data.
- Highly potent inhibitor with a reported Ki of 104 pM.
- Orally active compound effective in preclinical leukemia models.
- Selective mode of action targeting the Menin-MLL interaction.
- High purity suitable for biochemical and cellular studies.
- Supplied with datasheet, COA, and SDS for lab use.
- Available in small research quantities for preclinical experiments.
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Medchemexpress LLC Octinoxate | 5466-77-3 | 99.8% | 500 MG
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Octinoxate | 5466-77-3 | 99.8% | 500 MG
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Medchemexpress LLC Velnacrine maleate | 118909-22-1 | HY-W011246 | 98.0% | 330.34 | 100 MG
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Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
- Orally active
- Cholinesterase inhibitor
- Used for research of Alzheimer's disease
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Apexbio Technology LLC NB-598 Maleate 155294-62-5 50mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
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Apexbio Technology LLC Flupirtine maleate 75507-68-5 100mg
Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
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Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 25 MG
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Avitinib maleate is a third-generation, irreversible, and orally active selective EGFR inhibitor. It has IC50 values of 0.18 nM against both EGFR L858R and EGFR T790M, and 7.68 nM against wild-type EGFR. It is also a BTK inhibitor, inducing apoptosis and inhibiting BTK phosphorylation in mantle cell lymphoma. It exhibits anticancer effects.
- Third-generation, irreversible, and orally active selective EGFR inhibitor.
- Potent against EGFR L858R, EGFR T790M, and wild-type EGFR.
- BTK inhibitor.
- Induces apoptosis.
- Inhibits phosphorylation of BTK in mantle cell lymphoma.
- Exhibits anticancer effects.
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Medchemexpress LLC Setiptiline maleate | 85650-57-3 | 99.9% | 377.43 | 50 MG
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Setiptiline maleate is a serotonin receptor antagonist and a tetracyclic antidepressant (TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).
- Functions as a norepinephrine reuptake inhibitor.
- Acts as an α2-adrenergic receptor antagonist.
- Serves as a serotonin receptor antagonist, targeting 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes.
- Acts as an H1 receptor inverse agonist/antihistamine.
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TARGETMOL CHEMICALS INC ACEPROMAZINE MALEATE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ACEPROMAZINE MALEATE is a dopamine receptor antagonistpurity: 99%
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Apexbio Technology LLC Rosiglitazone maleate(Synonyms: Avandia, BRL 49653, BRL49653C, Rosiglitazone maleate salt, BRL49653, RGZ, Rosiglizole maleate), 10mM (in 1mL DMSO), CAS: 155141-29-0.
Rosiglitazone maleate (CAS 155141-29-0) is the maleate salt formulation of rosiglitazone a thiazolidinedione compound targeting the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR ) By selective activation of PPAR rosiglitazone increases insulin sensitivity of peripheral tissues facilitating glucose uptake and reduction of blood glucose levels Due to its insulin-sensitizing activity rosiglitazone maleate serves as an important research tool in diabetes and metabolic syndrome investigations However recent clinical studies also report associations with adverse cardiovascular events fluid retention and anemia underscoring considerations for risk-benefit evaluation in ongoing research
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Medchemexpress LLC Diethyl maleate | 141-05-9 | MFCD00009191 | 98.1% | 172.18 | C8H12O4 | 1g
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Diethyl maleate (DEM) is an orally available effective glutathione (GSH) depletor that crosses the blood-brain barrier Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0 1-0 5 mM Diethyl maleate selectively depletes GSH in liver lung and brain tissues exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO- Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3]
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Cayman Chemical Fluorescein diacetate, Purity: ≥98%, CAS: 596-09-8, 5 g
A cell-permeable fluorogenic cell viability probe; cleaved by intracellular esterases to produce fluorescein which displays excitation/emission maxima of 490/520 nm, respectively
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AdipoGen Naphtholfluorescein diacetate
Chemical. CAS 77084-71-0. Formula C32H20O7. Molecular Weight 516.5. Naphthofluorescein-diacetate is a non-fluoresent compound that is hydrolyzed by esterases to the fluorescent compound Naphthofluorescein. Spectral data lambdaex 594 nm lambdaem 663 nm in 0.1 M Tris pH 9.0 esterase. The fluorescent naphthofluorescein has been shown to be an inhibitor of furin.
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