Dicarboxylic acids and derivatives
Apexbio Technology LLC GlyH-101 328541-79-3 10mM (in 1mL DMSO)
GlyH-101 (CAS 328541-79-3) is a cell-permeable glycinyl hydrazone derivative that acts as a selective inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel exhibiting a Ki of 1 4 M By blocking CFTR-mediated chloride transport GlyH-101 serves as a valuable tool for investigating CFTR function in epithelial physiology and pathophysiology as well as for studying mechanisms underlying cystic fibrosis and related disorders involving chloride ion dysregulation
TARGETMOL CHEMICALS INC ULK-101 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ULK-101 is a potent and selective ULK1 inhibitor ( IC50s 8.3/30 nM for ULK1/ULK2). It can suppress autophagy. purity: 99%
Medchemexpress LLC Ucf-101 | 313649-08-0 | 99.7% | 495.51 g/mol | C27H17N3O5S | 10MM 1ML
Ucf-101 is a selective, competitive inhibitor of the pro-apoptotic serine protease Omi/HtrA2, supplied as a 10 mM solution in DMSO for research use. It inhibits His-Omi with IC50 = 9.5 μM, shows minimal activity against other serine proteases, and is provided with analytical documentation for quality and safety.
Medchemexpress LLC Ethyl Lauroyl Argina 1g
Ethyl Lauroyl Arginate Hydrochloride is an arginine derivative[1]
Medchemexpress LLC Lei 101 hydrochloride | 2250025-91-1 | 99.4% | 508.99 g/mol | C23H26ClFN4O4S | 10MM 1ML
LEI-101 hydrochloride is a potent, selective, orally bioavailable cannabinoid CB2 receptor agonist used for receptor pharmacology and preclinical research. It is provided in both solid form and as a ready-to-use DMSO solution to support biochemical and cellular assays.
Medchemexpress LLC 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine | 59752-57-7 | MFCD00042828 | 98.0% | 579.75 | C29H58NO8P | 25 MG
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) is a phosphatidylethanolamine lipid bearing lauric acid (12:0) acyl chains. It is commonly used as a lipid component in the preparation of liposomes and other lipid-based formulations for research use only. The material is supplied as a white to off-white solid with high purity and specified storage conditions.
- Phosphatidylethanolamine derivative with C12:0 acyl chains.
- Suitable as a lipid component for liposome synthesis.
- High purity for research applications.
- Available in small laboratory quantities (e.g., 25 mg, 50 mg, 100 mg).
- White to off-white solid; store powder at -20°C.
Medchemexpress LLC 1,2-Dilauroyl-sn-glycerol | 60562-15-4 | 98.0% | 50 MG
1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol that may be involved in second messenger signal transduction. It appears as a white to off-white solid with a molecular formula of C27H52O5 and a molecular weight of 456.70. This product is intended for research use only.
- Purity of 98.0%
- CAS number: 60562-15-4
- Soluble in DMSO (100 mg/mL), requiring ultrasonic for dissolution
- Ships at room temperature within the continental US
- Recommended storage for powder: -20°C for 3 years
- Recommended storage for in-solvent solutions: -80°C for 6 months, or -20°C for 1 month (aliquot and store to prevent inactivation from repeated freeze-thaw cycles)
- Related to metabolic enzymes/proteases and endogenous metabolites
- Acts as an inhibitor
Apexbio Technology LLC CAL-101 (Idelalisib, GS-1101) 870281-82-6 100mg
CAL-101 (Idelalisib GS-1101 CAS 870281-82-6) is a selective inhibitor targeting the p110 isoform of phosphatidylinositol 3-kinase (PI3K) an enzyme involved in signaling pathways critical for proliferation and survival of malignant B cells By inhibiting PI3K p110 CAL-101 reduces PI3K-mediated phosphorylation of Akt and other downstream factors leading to enhanced PARP cleavage and caspase activation ultimately inducing apoptosis in malignant B cells CAL-101 has been demonstrated to counteract survival signals initiated by molecules such as CD40 ligand (CD40L) TNF- and fibronectin This agent is valuable in investigating B-cell malignancies
Apexbio Technology LLC CUDC-101 1012054-59-9 50mg
CUDC-101 (CAS 1012054-59-9) is a multitargeted small molecule inhibitor that concurrently targets epidermal growth factor receptor (EGFR) HER2 and class I and II histone deacetylases (HDACs) By inhibiting EGFR and HER2 kinases directly and simultaneously blocking HDAC activity CUDC-101 downregulates multiple oncogenic signaling pathways including those mediated by Akt HER3 and MET Preclinical assessments demonstrate that CUDC-101 inhibits growth of diverse tumor cell lines and xenograft models notably including those resistant to EGFR-targeted agents such as lapatinib and erlotinib These characteristics render CUDC-101 valuable for oncology research and drug resistance studies
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-1g
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-50mg
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2