Dicarboxylic acids and derivatives
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 1mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Apexbio Technology LLC LOXO-101 1223405-08-0 100mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | MFCD00274131 | 98.1% | 379.96 g·mol⁻¹ | C19H38ClNO4 | 5 MG
Lauroyl-L-carnitine chloride is an acylcarnitine-derived absorption enhancer used in research to increase the oral bioavailability of peptide compounds. It is provided as a high-purity solid for laboratory use and can be prepared as solutions for experimental assays following recommended storage conditions.
- Orally active absorption enhancer for peptide compounds.
- Improves oral bioavailability of peptide therapeutics in preclinical studies.
- Supplied as a high-purity solid suitable for solution preparation.
- Available in small research pack sizes and larger quantities on request.
- Stable when stored sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- Molecular formula C19H38ClNO4; molecular weight 379.96 g·mol⁻¹.
Medchemexpress LLC UK-101 | 1000313-40-5 | 99.6% | 484.74 g/mol | 50 MG
UK-101 is a potent, selective inhibitor of the immunoproteasome β1i (LMP2) subunit, commonly used in proteasome biology and cancer research to study apoptosis and proteasome-mediated pathways.
- Potent LMP2 inhibition with an IC50 of about 104 nM.
- Demonstrates high selectivity versus related proteasome subunits for target-specific studies.
- Induces cell apoptosis, useful in cancer biology assays.
- High purity (≈99.6%) for reproducible experimental results.
- Soluble in DMSO (≈7.3 mg/mL) for easy stock preparation.
- Stable as a powder under low-temperature storage for long-term use.
- Provided in a small research pack suitable for laboratory assays.
![Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238871.png-250.jpg)
Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG
MAL3-101 is a small-molecule allosteric inhibitor of heat shock protein 70 (HSP70) used in cellular and biochemical research. It inhibits HSP70 ATPase activity by blocking interaction with Hsp40 co-chaperones, perturbing protein folding and proteostasis pathways. The compound is supplied as a high-purity research reagent (CAS 831217-40-4) and is intended for in vitro and preclinical studies only.
- Allosteric inhibitor of HSP70 ATPase activity.
- Blocks Hsp40-Hsp70 interaction to disrupt protein folding.
- Applicable to cellular models studying proteostasis and cancer biology.
- High reported purity supports reproducible results.
- Supplied in small quantities suitable for screening and pilot studies.
- For research use only; not for human or veterinary use.
Medchemexpress LLC AVN-101 hydrochlorid 5mg | 1061354-48-0 | 340.89 g/mol | C21H25ClN2 | 5 MG
AVN-101 hydrochloride is a brain-penetrant, orally active 5-HT7 receptor antagonist used in pharmacological research. Supplied as a 5 mg powder with high purity, it is suitable for in vitro assays and preclinical studies requiring selective serotonergic modulation.
- High purity suitable for research applications.
- Brain-penetrant profile for central nervous system studies.
- Orally active salt form compatible with dosing studies.
- Stable powder for sealed, low-temperature storage.
- Small packaging appropriate for early-stage research.
Apexbio Technology LLC AS 101 106566-58-9 10mg
AS 101 (CAS 106566-58-9) chemically known as ammonium trichloro(dioxoethylene-O O -)tellurate is a non-toxic immunomodulatory small molecule that acts primarily by inhibiting interleukin-10 (IL-10) signaling In cell-based studies AS 101 reduces IL-10 production and suppresses mesangial cell proliferation in a dose-dependent manner It has been shown to decrease tyrosine phosphorylation and nuclear translocation of STAT3 correlating with inhibition of IL-10 activity AS 101 stimulates IL-2 secretion and enhances immune cell function in both human and murine models In animal studies systemic administration confers bone marrow-sparing effects during chemotherapy mitigates alopecia enhances survival in sepsis models and modulates cytokine production These properties support its utility in investigating immune regulation and potential therapeutic interventions targeting cytokine-mediated pathologies
