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Organic compounds that contain two carboxyl groups; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from dicarboxylic acids.
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1,2-Dilauroyl-sn-glycerol is identified as a saturated diacylglycerol that might be involved in second messenger signal transduction. It is available as a solid, appearing white to off-white, with a molecular weight of 456.70 and the chemical formula C27H52O5. This compound is intended strictly for research purposes.
Saturated diacylglycerol.
May play a role in second messenger signal transduction.
Available in solid form.
Appears white to off-white.
Strictly for research use.
High purity of 98.0%.
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Ucf-101 is a selective, competitive inhibitor of the pro-apoptotic serine protease Omi/HtrA2, supplied as a 10 mM solution in DMSO for research use. It inhibits His-Omi with IC50 = 9.5 μM, shows minimal activity against other serine proteases, and is provided with analytical documentation for quality and safety.
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Sodium lauroyl glutamate is an anionic amino acid surfactant. It has the potential for irritant contact dermatitis and possible anti-irritating potential in a surfactant mixture on human skin. It is primarily used in cleaning products and has been shown to exhibit low irritation to nude mouse skin at 1% w/w for 1 hour. This product is for research use only and not sold to patients.
Anionic amino acid surfactant.
Low irritation to nude mouse skin at 1% w/w for 1 hour.
Primarily used in cleaning products.
Mild surfactant with a pH value of 5.41.
For research use only.
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Sodium lauroyl glutamate is an anionic amino acid surfactant primarily used in cleaning products. While it has the potential for irritant contact dermatitis, it also exhibits possible anti-irritating properties in surfactant mixtures on human skin. A 1% w/w solution demonstrates low irritation and has a pH value of 5.41.
Anionic amino acid surfactant
Mild surfactant
Used mainly in cleaning products
Exhibits possible anti-irritating potential in surfactant mixtures
Low irritation to nude mouse skin at 1% w/w solution
1% w/w solution has a pH value of 5.41
Appears as a white to off-white solid
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BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)
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Sulforhodamine 101 (60311-02-6) is a red-emitting fluorescent dye primarily utilized as a selective marker for astrocytes Sulforhodamine 101 selectively accumulates in astrocytes enabling differentiation from surrounding neuronal populations In neurobiological studies using live tissue imaging including acute brain slice preparations the dye facilitates visualization of astroglial cell morphology and cellular dynamics Based on these properties Sulforhodamine 101 holds research potential in the study of astrocyte-specific responses morphological characteristics and cell cell interactions within neuronal tissues
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PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research on ferroptosis, lipid peroxidation, and inflammation. It increases GPX4 enzymatic activity in cell-free and cellular assays (reported pEC50 = 4.7) and protects cells from cholesterol peroxide-induced toxicity.
Allosteric activator of GPX4, reported pEC50 = 4.7.
Increases GPX4 activity to ~150% in cell-free and cellular extracts at reported concentrations.
Demonstrated inhibition of ferroptosis and protection against lipid peroxide-induced cell death.
Molecular weight ~378.93 g·mol⁻¹ and chemical formula C14H23ClN4O2S2.
Supplied as a high-purity research chemical suitable for biochemical and cellular assays.
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UK-101 is a selective small-molecule inhibitor of the immunoproteasome β1i (LMP2) subunit used in biochemical and cellular research to probe immunoproteasome function and induce apoptosis in certain cancer models.
Selective LMP2 (β1i) inhibitor with reported IC50 of 104 nM.
Shows ~144-fold selectivity versus β1c and ~10-fold versus β5.
High reported purity (99.58%) suitable for research applications.
Molecular weight 484.74 g·mol⁻¹ and formula C25H48N2O5Si.
Soluble in DMSO and supplied in small research quantities, including 1 mg packs.
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Lauroyl-L-carnitine chloride is an orally active metabolite that exhibits anti-inflammatory effects and improves systemic and local phenotypes in TNBS mice. It significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis.
Orally active metabolite
Reverses decrease in target gene IL-10
Exhibits anti-inflammatory effects
Improves systemic and local phenotypes in TNBS mice
Alleviates Crohn's-like colitis
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PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
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UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It demonstrates cellular effects on HEK293 cells by inhibiting human EAAT1. This product is for research use only.
Acts as an EAAT1 inhibitor
Demonstrates cellular effects on HEK293 cells
Inhibits human EAAT1 anion currents
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GlyH-101 (CAS 328541-79-3) is a cell-permeable glycinyl hydrazone derivative that acts as a selective inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel exhibiting a Ki of 1 4 M By blocking CFTR-mediated chloride transport GlyH-101 serves as a valuable tool for investigating CFTR function in epithelial physiology and pathophysiology as well as for studying mechanisms underlying cystic fibrosis and related disorders involving chloride ion dysregulation
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Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. AV-101 (4-Cl-KYN) a prodrug antagonist at the glycine site of the NMDA receptor has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP monkeys. purity: 98%
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