Dicarboxylic acids and derivatives
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | C28H35FN4O6S | 25 MG
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. It contains an E3 ligase ligand plus an alkyl linker with a terminal amine, making it ready for conjugation to a target protein ligand.
- Functionalized von-Hippel-Lindau (VHL) protein ligand
- For PROTAC research and development
- Contains an E3 ligase ligand
- Alkyl linker with terminal amine for conjugation
- VHL protein is a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Used by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein
Selleck Chemical LLC MZ-101-E1913-25MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 50 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It demonstrates cellular effects on HEK293 cells by inhibiting human EAAT1. This product is for research use only.
- Acts as an EAAT1 inhibitor
- Demonstrates cellular effects on HEK293 cells
- Inhibits human EAAT1 anion currents
Apexbio Technology LLC LOXO-101 1223405-08-0 100mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 25 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It is for research use only.
- Inhibits EAAT1 anion currents in a concentration-dependent manner
- Suitable for research applications
Medchemexpress LLC PKUMDL-LC-101-D04 1g | 2143896-83-5 | 378.94 | C14H23ClN4O2S2 | 1 G
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) supplied as a hydrochloride research chemical. It increases GPX4 enzymatic activity (reported pEC50 = 4.7) and has been used in cell and animal studies to inhibit ferroptosis and reduce inflammation. Molecular formula C14H23ClN4O2S2; molecular weight 378.94 Da.
- Allosteric activator of glutathione peroxidase 4 (GPX4).
- Reported activity pEC50 = 4.7 in biochemical assays.
- Hydrochloride salt form for improved stability and handling.
- Molecular formula C14H23ClN4O2S2, molecular weight 378.94 Da.
- Provided as a research reagent; not for human use.
- Typical pack size: 1 g.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Medchemexpress LLC RG-101 sodium | 00-00-0 | 95.4% | 8537.6 (free acid) | C295H410N78Na19O146P19S17 | 5 MG
RG-101 sodium is a hepatocyte-targeted N-acetylgalactosamine (GalNAc)-conjugated antisense oligonucleotide that antagonizes microRNA-122 (miR-122), a host factor important for hepatitis C virus replication. Supplied as a sodium salt, it is used in research to study miR-122 biology and antiviral mechanisms.
- Hepatocyte-targeted GalNAc conjugate for liver delivery.
- Antagonizes miR-122 to modulate hepatitis C virus-related pathways.
- High molecular weight oligonucleotide for sequence-specific activity.
- High purity (95.4%) suitable for research applications.
- Soluble in water; sonication may be required for dissolution.
- Recommended storage at -20°C; in solution store at -80°C for long-term.
Medchemexpress LLC Lei-101 hydrochloride | 2250025-91-1 | 99.4% | 508.99 | C23H26ClFN4O4S | 100MG
LEI-101 is a potent, selective cannabinoid CB2 receptor agonist used for biochemical and pharmacological research. It shows high selectivity for CB2 over CB1, is orally bioavailable, and is supplied as a solid for laboratory studies. Intended for research use only (not for human use).
- Selective CB2 receptor agonist with approximately 100-fold selectivity over CB1.
- Orally bioavailable, suitable for in vivo pharmacology studies.
- High purity (99.35%).
- Molecular weight 508.99 and formula C23H26ClFN4O4S.
- Soluble in DMSO (approx. 116.7 mg/mL).
- Intended for laboratory research use only, not for human consumption.
TARGETMOL CHEMICALS INC AV-101 5MG
Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. AV-101 (4-Cl-KYN) a prodrug antagonist at the glycine site of the NMDA receptor has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP monkeys. purity: 98%
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.1% | 25 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment (excitation/emission: 411 nm/512 nm) that exhibits solid-state fluorescence and is available as a commercial colorant. It is suitable for laboratory centrifugation and storage.
- Excitation/emission: 411 nm/512 nm
- Exhibits solid-state fluorescence
- For research use only
Medchemexpress LLC MZ-101 (GYS1-IN-2) | 2839908-40-4 | 99.0% | 449.52 | C25H28FN5O2 | 10 MG
MZ-101 (GYS1-IN-2) is an orally active, potent, and selective small-molecule inhibitor of glycogen synthase 1 (GYS1) with an IC50 of 0.041 μM. It reduces glycogen concentrations in cells and in mice and is used to study GYS1-mediated Pompe disease and other glycogen storage disorders.
- Potent, selective GYS1 inhibition (IC50 = 0.041 μM).
- Reduces glycogen concentrations in cells and animal models.
- Orally active small molecule suitable for in vivo studies.
- High purity (98.98%) and solid physical form for storage stability.
- Available in small solid quantities and DMSO solutions for flexible dosing.
- Storage: powder stable at -20 °C (up to three years) and 4 °C (up to two years).
Medchemexpress LLC 1,2-dilauroyl-3-chloropropanediol | 1051389-99-1 | MFCD34647394 | >98.0% | 475.14 g·mol⁻¹ | C27H51ClO4 | 5 MG
1,2-dilauroyl-3-chloropropanediol is a chloropropanediol ester used as a research-grade lipid reagent for analytical and synthetic applications. It has molecular formula C27H51ClO4, molecular weight ≈475.14 g·mol⁻¹, and CAS 1051389-99-1. The compound is typically supplied as a solid with reported purity >98% and is recommended to be stored at -20 °C.
- High purity (>98%) suitable for analytical and synthetic workflows.
- Well-defined molecular identity: C27H51ClO4; MW 475.14 g·mol⁻¹; CAS 1051389-99-1.
- Solid form facilitates accurate weighing and handling.
- Small pack sizes available for method development and reference use.
- Recommended cold storage to maintain stability.
Medchemexpress LLC BNC-101 1mg | 1mg
BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC BNC-101 10mg | 10mg
BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)