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Imidazoles

Aromatic organic heterocyclic compounds that consist of a diazole with non-adjacent nitrogen atoms with the formula: C3N2H4.

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1

Medchemexpress LLC Ro 90-7501 | 293762-45-5 | 99.1% | 340.38 | C20H16N6 | 5 MG
SDP

Ro 90-7501 is a small-molecule research compound (C20H16N6, MW 340.38, CAS 293762-45-5) that inhibits amyloid β42 fibril assembly and reduces Aβ42-induced cytotoxicity. It also inhibits ATM phosphorylation and DNA repair, modulates innate antiviral responses, inhibits protein phosphatase 5, and has reported radiosensitizing activity in cellular models.

  • Inhibits amyloid β42 fibril assembly (reported EC50 ≈ 2 μM).
  • Inhibits ATM phosphorylation and impairs DNA repair.
  • Inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner.
  • Shows radiosensitizing activity in certain cancer cell models.
  • High reported purity (99.1%).
  • Supplied as a 5 mg research sample for laboratory studies.

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2

Medchemexpress LLC Ro 90-7501 | 293762-45-5 | 99.1% | 340.38 g/mol | C20H16N6 | 10 MG
SDP

Ro 90-7501 is a small-molecule research compound that inhibits amyloid β42 (Aβ42) fibril assembly and reduces Aβ42-induced cytotoxicity (EC50 2 μM). It also modulates protein phosphatase activity and DNA damage response pathways, enhances innate antiviral signaling, and has demonstrated radiosensitizing effects in cell models.

  • Inhibits amyloid β42 fibril assembly and reduces Aβ42 cytotoxicity (EC50 2 μM).
  • Inhibits protein phosphatase 5 and modulates ATM phosphorylation and DNA repair.
  • Enhances TLR3 and RIG-I-like receptor-mediated IFN-β expression.
  • Shows radiosensitizing effects in cancer cell models.
  • High purity (99.1%) and characterized molecular weight (340.38 g/mol).
  • Soluble in DMSO (≈41.67 mg/mL) with recommended storage for powder and solutions.

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3

Medchemexpress LLC Ro 90-7501 | 293762-45-5 | 99.1% | 340.38 g/mol | C20H16N6 | 100 MG
SDP

Ro 90-7501 is a small-molecule research compound that inhibits amyloid β42 (Aβ42) fibril assembly and reduces Aβ42-induced cytotoxicity. It is characterized by CAS 293762-45-5, molecular formula C20H16N6, molecular weight 340.38 g/mol, and reported purity of approximately 99.1%.

  • Inhibits amyloid β42 fibril assembly and reduces Aβ42-induced cytotoxicity (EC50 2 μM).
  • Well characterized: CAS 293762-45-5 and molecular weight 340.38 g/mol.
  • High purity suitable for biochemical and cellular assays.
  • Available in multiple pack sizes including 100 mg for laboratory use.

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4

Medchemexpress LLC 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine | 293762-45-5 | 99.1% | 340.38 g/mol | C20H16N6 | 25 MG
SDP

Ro 90-7501 is a small-molecule research compound that inhibits amyloid β42 (Aβ42) fibril assembly and reduces Aβ42-induced cytotoxicity. It has reported activity affecting DNA damage response and phosphatase regulation, and has been used in studies of radiosensitization and antiviral innate immune modulation.

  • Inhibits amyloid β42 fibril assembly and reduces Aβ42-induced cytotoxicity (EC50 ≈ 2 μM).
  • Reported to inhibit ATM phosphorylation and impair DNA repair.
  • Modulates innate immune signaling and inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner.
  • Used in neurodegeneration, amyloid aggregation, and radiosensitization research applications.
  • Molecular formula C20H16N6 and molecular weight 340.38 g/mol.
  • Purity typically reported ≈99.1% and soluble in DMSO.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Ro 90-7501 | 293762-45-5 | MFCD00367977 | 99.1% | 340.38 g·mol⁻1 | C20H16N6 | 50 MG
SDP

Ro 90-7501 is a small-molecule research compound that inhibits amyloid β42 (Aβ42) fibril assembly and reduces Aβ42-induced cytotoxicity. It has reported activities including inhibition of ATM phosphorylation and protein phosphatase 5 (PP5), enhancement of antiviral signaling, and radiosensitizing effects in cancer cells. Purity is 99.1% and molecular formula is C20H16N6.

  • Inhibits amyloid β42 fibril assembly (EC50 ≈ 2 μM).
  • Reduces Aβ42-induced cytotoxicity in cell-based assays.
  • Inhibits ATM phosphorylation and PP5 activity.
  • Enhances TLR3/RLR-induced IFN-β expression and antiviral responses.
  • Available in multiple pack sizes, including 50 MG.

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6

Medchemexpress LLC N-[(2R)-4-amino-3,4-dioxo-1-phenylbutan-2-yl]-4-(2-fluorophenyl)-2-methyl-1,3-oxazole-5-carboxamide | 2221010-42-8 | 98.0% | 395.38 | C21H18FN3O4 | 5 MG
SDP

Dazcapistat is a research-grade calpain inhibitor with reported IC50s of <3 μM for calpain 1, calpain 2, and calpain 9. Supplied as a white to off-white solid with a stated purity of 98.0%, it is intended for in vitro and in vivo research; follow supplier protocols for solubility, formulation, and storage.

  • Molecular formula C21H18FN3O4; molecular weight 395.38
  • Purity 98.0%
  • Appearance white to off-white solid
  • In vitro solubility: DMSO 100 mg/mL (ultrasonic recommended)
  • In vivo formulation: ≥2.5 mg/mL in recommended vehicle protocols (10% DMSO/40% PEG300/5% Tween-80/45% saline; alternatives available)
  • Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month)

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