Gel Electrophoresis Reagents and Buffers
Electron Microscopy Sciences EMS PHEM Buffer 500 ML
PHEM buffer has been used primarily for tissues and cell cultures being processed for immunocytochemical studies. Most antigens, especially intra cellular ones, stain better using PHEM than those processed using PBS, it also has a more limited effect on biochemical reactions and enzymes. Very good preservation of cellular ultrastructure, notably microtubules, is also an advantage of PHEM use.
Sigma Aldrich Fine Chemicals Biosciences Acrylamide/Bis-acrylamide
Acrylamidenbsp(AA) is a neurotoxin and carcinogen. It was found in potato products like french fries and potato chips and also in several cereal-based products. This highly reactive organic compound has the ability to polymerize to form polyacrylamide.
ABclonal Technology KCNU1 Rabbit pAb
This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants.
ABclonal Technology FSHR Rabbit pAb
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
ABclonal Technology TSPAN15 Rabbit pAb
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene.
ABclonal Technology JARID1B Rabbit pAb
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.
ABclonal Technology KIF20B Rabbit pAb
Enables several functions, including WW domain binding activity, plus-end-directed microtubule motor activity, and protein homodimerization activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton, midbody, and nuclear lumen.
ABclonal Technology PPL Rabbit pAb
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
ABclonal Technology VPS37A Rabbit pAb
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.
ABclonal Technology MTMR4 Rabbit pAb
Enables protein phosphatase binding activity. Involved in regulation of phosphatidylinositol dephosphorylation. Located in endosome.
ABclonal Technology ANG Rabbit pAb
This gene encodes angiogenin, a member of the RNase A superfamily with weak ribonucleolytic activity. Angiogenin mediates blood vessel formation by binding to actin on endothelial cells and accumulates in the nucleolus, stimulating ribosomal transcription. Under stress, it translocates to the cytosol, hydrolyzing tRNAs and affecting protein synthesis. The mature protein has a nuclear localization signal, a cell binding motif, and antimicrobial activity against bacteria and fungi. It is neurotrophic, neuroprotective, and plays roles in cell growth and tumor progression. Mutations are associated with amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 share promoters and exons, but splice into distinct coding regions. Alternative splicing results in multiple transcript variants encoding the same protein.
ABclonal Technology ACSM2A Rabbit pAb
This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID 348158), both present on chromosome 16, likely arose from a chromosomal duplication event.
ABclonal Technology RASD1 Rabbit pAb
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimers disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.