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Oligonucleotides with a wide variety of applications in microarrays, gel shift assays, artificial gene synthesis, PCR, DNA sequencing, molecular cloning, and other custom procedures. Available in multiple primer lengths; may be pre-designed or random.
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EZ Cap Cre mRNA 5-moUTP encodes Cre recombinase a tyrosine recombinase enzyme that facilitates homologous DNA recombination between two specific loxP recognition sites It is designed to promote precise DNA recombination thereby enabling conditional gene modification in mammalian systems EZ Cap Cre mRNA 5-moUTP exerts its biological activity primarily through expression of Cre recombinase which catalyzes site-specific recombination at loxP sites This mRNA incorporates a Cap 1 structure and 5-methoxyuridine triphosphate (5-moUTP) modification to reduce innate immune responses and improve translational stability Based on these properties EZ Cap Cre mRNA 5-moUTP holds research potential in genome editing experiments conditional gene knockout studies and reporter gene activation in mammalian research models
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Antigen: His-tag recombinant mouse Dnmt3a expressed in bacteria • Isotype: IgG1 • Host: mouse, clone 64B814.1 • Cross Reactivity: (+) human and mouse DNMT3a • Application(s): ELISA • The DNMT3 family members DNMT3a and DNMT3b are strongly expressed in embryonic stem cells. Their expression is down regulated in differentiating cells and low in adult sematic tissue.
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The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes T lymphocytes monocytes granulocytes and some B lymphocytes It may be part of a physiologic ligand-receptor complex involved in T-cell activation During T-cell activation this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site suggesting a negative regulatory role in adaptive immune response
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The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
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