Oligonucleotides
Abcam GSK503, EZH2 methyltransferase inhibitor, 10MG
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Phospho-EZH2/KMT6-T311 Rabbit pAb
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Cayman Chemical GrIes Reagent R2 1ea
Griess Reagent component for determination of nitrite in aqueous solutions.
Carnabio Usa Inc CK1E(CSNK1E)/5UG/CATALYTIC
CK1(CSNK1E), Catalytic domain, Wild type, Amino Acid 1-348, NP_001885.1, Expressed in Insect (sf21); 5microg
ABclonal Technology CD43 Rabbit mAb
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes T lymphocytes monocytes granulocytes and some B lymphocytes It may be part of a physiologic ligand-receptor complex involved in T-cell activation During T-cell activation this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site suggesting a negative regulatory role in adaptive immune response
Abcam Chromatin Extraction Kit - Flexible Format.
Chromatin Extraction Kit - Flexible Format.
The product is subject to the following: Abcam Restricted Use Statement
American Research Products Inc Mouse TGFb1 ELISA Kit
This Mouse Transforming Growth Factor Beta 1 (TGFb1) ELISA Kit is a precoated Sandwich ELISA assay designed to detect and quantify the target analyte in serum platelet-poor plasma tissue homogenates cell culture supernatants and other biological fluids This product is for Research Use Only
Medchemexpress LLC sEH inhibitor-1 (compound TCPU) | 1208549-68-1 | 99.6% | 10 MG
sEH inhibitor-1 (TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with low-nanomolar potency in human and murine assays. It is supplied as a high-purity research-grade compound for biochemical and pharmacological studies.
- Low-nanomolar potency (human IC50 0.4 nM; murine IC50 5.3 nM).
- Molecular formula C17H20F3N3O3 and molecular weight 371.35 g/mol.
- High purity suitable for research (99.62%).
- Available in small milligram pack sizes for in vitro and in vivo experiments.
- Targets soluble epoxide hydrolase for mechanistic and pharmacological studies.
ABclonal Technology Phospho-PTEN-S380 Rabbit pAb
This gene encodes a tumor suppressor protein that functions as a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases, but specifically dephosphorylates phosphoinositides. By regulating phosphatidylinositol-3,4,5-trisphosphate levels, it negatively controls the AKT/PKB signaling pathway. A non-canonical upstream initiation site produces a longer isoform associated with the mitochondrial inner membrane, potentially involved in energy metabolism regulation. A pseudogene of this gene is located on chromosome 9. Alternative splicing and multiple translation start sites result in various isoforms.
Biotium SOX9 / SRY-box 9(SOX9/3141R), CF405S conjugate, 0.1mg/mL
Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye col
Medchemexpress LLC Tak1 protein, human (Sf9) | ≥98.0% | 20UG
Recombinant human TAK1 protein produced in Sf9 insect cells, supplied as a tag-free, highly purified preparation suitable for biochemical assays, kinase activity studies, and antibody validation. Provided in small-scale quantities; aliquot and store frozen to preserve activity.
- Tag-free recombinant human TAK1 protein.
- Expressed in Sf9 insect cells for eukaryotic post-translational modifications.
- High purity suitable for biochemical and cell-based assays.
- Low endotoxin level for sensitive applications.
- Supplied at a concentration that facilitates small-volume assays.
- Stable when stored at -80°C; avoid repeated freeze-thaw cycles.
ABclonal Technology SEC14L2 Rabbit pAb
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
BIOHIPPO AAV-GfaABC1D-DIO-EYFP-P2A-DTA-WPRE-hGH-polyA
Recombinant adeno associated virus expressing DTA fused to EYFP under the GfaABC1D promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Meridian Life Science Gly-Free DNA Helicase -HC, 20UL
Glycerol-Free DNA Helicase (HC) Kit is a multi-domain enzyme with both ATPase and helicase activities. It unwinds double-stranded DNA with 3’ to 5’ with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Helicase works in coordination with an accessory protein, methyl-directed mismatch repair (MutL) protein that stimulates the helicase activity. Glycerol-Free DNA Helicase (HC) has been optimized to deliver excellent, stable performance without glycerol, allowing you to deliver reliable results with the added capability for lyophilization. This gives you the flexibility to confidently store mixtures at ambient temperature or produce diagnostic assays that rely on miniaturized reaction components, such as point-of-care assays.
BIOHIPPO AAV-CRH-Cre-P2A-EGFP-WPREs
Recombinant adeno associated virus expressing Cre fused to EGFP under the CRH promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.