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CD70 is the ligand of CD27 in activated T and B lymphocytes is an important cytokine in CD70-CD27 pathway involving with the generation and maintenance of T cell immunity[1] CD70 is a surface antigen also shows antiviral activity and regulates viability of tumor cells and regulatory T cells[2][3] As for CD70 protein in rat contains TNF 2 domain (57-188 a a) and transmembrane helix belonging to the tumor necrosis factor (TNF) family CD70 Protein Rat (HEK293 Fc) is 150 amino acids in length (Q46-P195) and is expressed in the HEK293 cells with N terminal hFc-tag
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The CD6 protein is a cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses through interaction with ALCAM/CD166 It functions as a costimulatory molecule promoting T cell activation proliferation and contributing to the formation of immune synapses CD6 Protein Human (HEK293 Fc) is the recombinant human-derived CD6 protein expressed by HEK293 with C-hFc labeled tag
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Fibroblast Growth Factor-basic (FGF-basic) also known as FGF-2 is a pleiotropic cytokine FGF-basic is produced by fibroblasts and vascular cells It regulates a variety of processes including cell proliferation differentiation survival adhesion motility apoptosis limb formation and wound healing FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling
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The Meso Scale Discovery U-PLEX Human FGF Basic Assay is a multiplex immunoassay kit for quantifying human FGF basic in various biological matrices It uses electrochemiluminescence detection offering high sensitivity a dynamic range of up to 5 logs and low sample consumption The assay requires 50 L of sample and is compatible with Meso Scale Discovery instruments like the MESO QuickPlex SQ 120 series The kit includes a 96-well plate with capture antibodies detection antibodies with electrochemiluminescent tags and a calibrator with recombinant FGF basic
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The Meso Scale Discovery U-PLEX Mouse FGF-21 Assay Kit is an electrochemiluminescent immunoassay for the quantitative measurement of FGF-21 in mouse serum plasma and cell culture supernatants The assay uses MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive and reproducible results with low sample volume requirements The kit includes a 96-well plate coated with capture antibodies specific for mouse FGF-21 detection antibodies conjugated to MSD SULFO-TAG calibrators and sample diluent The assay has a typical sensitivity of 1 5 pg/mL and an upper limit of quantification of 10 000 pg/mL
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Four distinct genes encoding closely related FGF receptors FGF R1-4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation differentiation and apoptosis Plays an essential role in the regulation of chondrocyte differentiation proliferation and apoptosis and is required for normal skeleton development Regulates both osteogenesis and postnatal bone mineralization by osteoblasts
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Four distinct genes encoding closely related FGF receptors FGF R1 - 4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid-box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains referred to as the alpha isoform or only IgII and IgIII referred to as the beta isoform
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The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
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The U-PLEX Human TGF 1 Assay (K151XWK) is a multiplex electrochemiluminescence immunoassay from Meso Scale Discovery for quantitative measurement of transforming growth factor beta 1 in human biological samples This research-grade assay utilizes proprietary MULTI-SPOT and MULTI-ARRAY technology platforms offering high sensitivity wide dynamic range and minimal sample volume requirements The kit includes pre-coated plates detection antibodies calibrators and all necessary reagents for reliable TGF 1 quantification in serum plasma and cell culture supernatants for biomedical research applications
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Four distinct genes encoding closely related FGF receptors FGF R1-4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation differentiation and apoptosis Plays an essential role in the regulation of chondrocyte differentiation proliferation and apoptosis and is required for normal skeleton development Regulates both osteogenesis and postnatal bone mineralization by osteoblasts
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TPST1 (tyrosyl protein sulfotransferase 1) catalyzes the O-sulfation of tyrosine residues located within the acidic motifs of polypeptides utilizing 3 -phosphoadenylate sulfate (PAPS) as a co-substrate This enzymatic activity plays a crucial role in post-translational modification processes especially sulfation which contributes to the structural and functional diversity of proteins TPST1 Protein Human (HEK293 His) is the recombinant human-derived TPST1 expressed by HEK293 with N-His labeled tag
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HPRG protein is a multifunctional plasma glycoprotein with the ability to bind multiple ligands including heme heparin thrombospondin etc HPRG regulates immune processes angiogenesis coagulation and fibrinolysis through zinc-dependent binding to heparin and glycosaminoglycans HPRG Protein Human (HEK293 His) is the recombinant human-derived HPRG protein expressed by HEK293 with C-His C-10 His labeled tag
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The DDR2 protein is a tyrosine kinase critical in tissue remodeling acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation extracellular matrix remodeling migration and proliferation DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2 DDR2 Protein Human (HEK293 His) is the recombinant human-derived DDR2 protein expressed by HEK293 with C-His labeled tag
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