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An agonist of group I mGluRs; induces phosphoinositol hydrolysis in MCB3901 cells expressing human mGluR1a and mGluR5a; potentiates NMDA-induced depolarizations in rat hippocampal slices at 10 µM; intrathecal administration increases mean blood pressure in anesthetized rats at 300 nmol/animal; induces seizures in rats at 1.5 µmol/animal, i.c.v.
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There are five immunoglobulin classes in humans. Out of these immunoglobulin M (IgM) is a high molecular weight protein that has five or six subunits. IgM monomers are made of two heavy chains and two light chains connected by a disulfide bond. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.IgM antibodies are present as pentamers in the serum and are produced in response to antigens.IgM from human serum is purified from normal human serum by precipitation and gel filtration techniques. The immunoglobulin is determined to be atleast 95% pure by HPLC procedures.
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Disposable sterile tubes with caps made of polyethylene (PE) and have the popular two position design (up/loose for aerobic work and down/sealed for anaerobic cultures). Polystyrene tubes may be centrifuged at up to 2000xg. Polypropylene tubes are able to withstand higher centrifugal forces, up to 4000xg.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An active metabolite of norepinephrine; induces contractions in isolated rabbit aortic strips; inhibits norepinephrine uptake in isolated rat heart (IC50 = 200 µM); plasma levels of normetanephrine are increased in patients with von Hippel-Lindau disease and pheochromocytomas compared with patients with von Hippel-Lindau disease without pheochromocytomas; has been used as a marker of authentic human urine specimens
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