Sera
Cayman Chemical Dipsacoside B 50MG
A triterpenoid saponin with hepatoprotective activity; enhances acetaminophen-induced autophagy and inhibits acetaminophen-induced apoptosis in HepG2 cells at 0.5 µM; increases survival in a mouse model of acetaminophen-induced acute liver failure at 50 mg/kg
Cayman Chemical TalnIflumate 50mg
A prodrug form of niflumic acid; decreases the rate of chloride/bicarbonate exchange in isolated mouse intestinal villous epithelial cells at 100 µM; dietary administration increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome at 88 mg/kg
Cayman Chemical SKQ1bromIde 50mg
A mitochondrial antioxidant; decreases transmembrane potential and production of ROS; prevents neuronal loss and synaptic damage in rat AD model; slows development of ocular pathologies; prevents acute phenoptosis following rhabdomyolysis, stroke, and myocardial infarction
Cayman Chemical Montelukast 50mg
A CysLT1 receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor); selective for CysLT1 over CysLT2 receptors (IC50 = >10,000 nM in COS-7 cell membranes expressing the human receptor); inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 69 nmol/kg, p.o.); inhibits ovalbumin-induced airway hyperresponsiveness and increases in the number of total cells and eosinophils in BALF in a mouse model of allergic asthma at 3 and 10 mg/kg
Cayman Chemical SIKVAVacetate 100mg
A laminin α1-derived peptide; binds to α3, α6, and β1 integrins; induces adhesion of CAC2 adenoid cystic carcinoma cells at 1 UG/ml; stimulates the proliferation, migration, and secretion of EGF, VEGF, TGF-β, and FGF in primary mouse fibroblasts at 100 UG/ml; topical administration of a chitosan hydrogel containing SIKVAV promotes wound healing and angiogenesis in mice
Cayman Chemical Oxyresveratrol 50mg
A resveratrol analog; scavenges H2O2 and NO (IC50 = 45.3 μM) and DPPH (IC50 = 28.9 μM); reduces brain infarct volume and reduces cytochrome c release and caspase-3 activation in an in vivo model of stroke at 10 mg/kg; inhibits tyrosinase activity (IC50s = 1.2 and 52.7 μM in mushroom and mouse melanoma B-16 cells, respectively)
Cayman Chemical MaduramIcInamonIum salt 100mg
A polyether ionophore antibiotic; selectively binds to monovalent cations over divalent cations; active against Gram-positive bacteria (MICs = 0.9-125 UG/ml); reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively); reduces P. berghei transmission in a mouse model of malaria at 4 and 8 mg/kg; reduces the severity of lesions and completely protects chicks against mortality in a model of E. tenella-induced coccidiosis at 5-10 ppm in the diet
Cayman Chemical MethsuxImIde 100mg
An anticonvulsant; inhibits CYP2C19-mediated metabolism of chlorproguanil and proguanil at 100 µM; protects against leptazol-induced convulsions in rats when administered at a dose of 100 mg/kg
Cayman Chemical CInacalcethydrochlorIde 100mg
An allosteric agonist of the CaSR (EC50 = 79.4 nM in HEK293T cells expressing the human receptor); decreases plasma levels of PTH in rats from 0.1-10 mg/kg; decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism
Cayman Chemical Apocarotenal 50mg
A carotenoid with genotoxic and antioxidant activities and an active metabolite of β-carotene; scavenges free radicals in a TEAC assay at 100 µM; increases the percentage of micronucleated cells and the number of sister chromatid exchanges and chromosomal aberrations in primary rat hepatocytes at 10 µM
Cayman Chemical 2CLOroN6Cyclopentyladenos 50mg
An adenosine A1 receptor antagonist; selectively binds to adenosine A1 over adenosine A2 receptors (Kis = 0.4 and 3,900 nM, respectively); inhibits forskolin-induced adenylate cyclase activity in rat fat cell membranes (IC50 = 33 nM); increases the electroconvulsive threshold in a mouse model of MES-induced seizures at 0.25 and 0.5 mg/kg; reduces infarct size in a rabbit model of coronary artery occlusion-induced myocardial infarction at 0.125 mg/kg
Cayman Chemical 3Deoxy3fluorothymIdIn 50mg
A nucleoside analog; a TK1 substrate; inhibits TK1 and TK2 (Kis = 6 and 10 µM, respectively); inhibits HIV-1 reverse transcriptase (EC50 = 5 nM) and the replication of HIV-1 in MT-4 cells (EC50 = 5 nM); decreases mtDNA levels and the OCR and induces upregulation of CD11b in OCI-AML-2 and MV4-11 cells; reduces tumor growth in an OCI-AML-2 AML mouse xenograft model at 50 mg/kg; a radiolabeled form is commonly used as a PET tracer for in vivo imaging of tumors
Cayman Chemical DImaprIthydrochlorIde 100mg
A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner
Cayman Chemical LumogalIon 100mg
A fluorescent probe for aluminum; binds to aluminum, forming a complex that displays excitation/emission maxima of 500/590 nm, respectively; has been used to detect aluminum in natural waters and human urine and serum samples by HPLC, as well as in fixed soybean roots and THP-1 cells by confocal microscopy