Sera
Cayman Chemical Vnpocetn 50mg
An inhibitor of PDE1 that has diverse cerebral and neurological effects in vivo; also directly inhibits IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo
Cayman Chemical ArcaInsulfate 50mg
An NMDA receptor antagonist (IC50 = 9.13 µM); inhibits NMDA and glycine-induced inward currents in X. laevis oocytes expressing rat NMDA receptors (IC50 = 60.1 µM); impairs contextual and auditory fear conditioning in rats when administered post-training at 10 mg/kg, i.p.
Cayman Chemical 10 11dIhdro10hdrox Carb 50mg
An antiepileptic agent and active metabolite of oxcarbazepine; a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine
Cayman Chemical 2 NEthylperfluoroctnsulf 50mg
A perfluoroalkyl substance; has been found in wastewater samples; associated with decreased plasma levels of maternal and fetal free T4
Cayman Chemical 6dIazo5oxoLnorLeucIn 50mg
A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase
Cayman Chemical EburnamonIn 100mg
An indole alkaloid with vasodilator and neuroprotective activities; increases cerebral blood flow and capillary circulation in anesthetized dogs at 2.5 mg/kg; prevents scopolamine-induced amnesia in a passive avoidance test in mice at 20 mg/kg; enhances acquisition of the conditioned avoidance response induced by hypobaric hypoxia in rats at 20 mg/kg; increases the onset time to hypoxia-induced brain death in rats at 0.25 mg/kg per minute; increases survival time and inhibits decreases in body temperature induced by hypobaric hypoxia in rats at 45 mg/kg
Cayman Chemical BIalaphosodIum salt 100mg
A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 µM); used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter
Cayman Chemical TebufenozIde 100mg
An insecticide and ecdysone receptor agonist (IC50 = 0.85 nM); induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva); inhibits p-glycoprotein in LLC-PK1 porcine kidney epithelial cells transfected with MDR1 (IC50 = 21.5 µM); decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 UG/ml
Cayman Chemical DIhydrophytol 100mg
An intermediate in the biosynthesis of phytanic acid; produced from phytol in the rumen of cattle
Cayman Chemical InosIn 5-trIphosphatesodI 50mg
A nucleoside triphosphate; alternative substrate for ATPases and GTPases; has been used to study activation and binding kinetics of nucleoside interaction with various ATPases and GTPases
Cayman Chemical ThIocolchIcIn 100mg
An inhibitor of microtubule assembly (IC50 = 2.5 µM); inhibits binding of colchicine to tubulin (Ki = 0.7 µM); inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM)
Cayman Chemical EsomeprazolesodIum salt 100mg
An H+/K+-ATPase inhibitor; reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay; inhibits histamine-induced gastric acid secretion in rats at 30 mg/kg, s.c.
Cayman Chemical FInasterIde 100mg
An inhibitor of 5α-reductase type II (IC50 = 4.2 nM); 100-fold selective for 5α-reductase type II over type I; does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and HO-1; decreases prostatic diameter and volume, as well as dihydrotestosterone serum levels in dogs with spontaneous benign prostatic hypertrophy at 0.1 and 0.5 mg/kg; reduces testosterone-induced type I procollagen and TGF-β1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia at 0.1 µM
Cayman Chemical OrphenadrInhydrochlorIde 50mg
A muscarinic acetylcholine receptor antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 mAChRs, respectively); decreases oxotremorine-induced muscle activity in rabbits at 2-5 mg/kg; an NMDA receptor antagonist (Ki = 6 µM in human postmortem frontal cortex; IC50 = 16.2 µM in cultured superior colliculus neurons)