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Cayman Chemical MethsuxImIde 100mg
An anticonvulsant; inhibits CYP2C19-mediated metabolism of chlorproguanil and proguanil at 100 µM; protects against leptazol-induced convulsions in rats when administered at a dose of 100 mg/kg
Cayman Chemical CInobufagIn 50mg
A cardiotonic steroid that has diverse biological activities; inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates at 0.3 μM; is cytotoxic to HCT116 cells in vitro (IC50s = <50 ng/ml at 48- and 72-hour time points) and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 10 mg/kg; inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells at 1 μg/ml; increases expression of hBD2 and hBD3 in dendritic cells; exhibits antinociceptive effects in mice
Cayman Chemical Apocarotenal 50mg
A carotenoid with genotoxic and antioxidant activities and an active metabolite of β-carotene; scavenges free radicals in a TEAC assay at 100 µM; increases the percentage of micronucleated cells and the number of sister chromatid exchanges and chromosomal aberrations in primary rat hepatocytes at 10 µM
Cayman Chemical NorelgestromIn 50mg
An active metabolite of norgestimate; an agonist of the progesterone receptor and ERα (EC50s= 11.1 and 43.4 nM, respectively); an antagonist of the glucocorticoid and mineralocorticoid receptors (IC50s = 255 nM and 83.7 nM, respectively); selectively binds progestin receptors (IC50 = 4.61 nM for rabbit uterine receptors) over androgen receptors (IC50 = 222 nM for rat prostatic receptors); activates the androgen receptor in a transactivation assay in MDA-MB-231 cells expressing the human receptor
Cayman Chemical 3 4mthylendIoypropIopheno 50mg
An analytical reference standard categorized as a precursor in the synthesis of cathinones; intended for research and forensic applications
Cayman Chemical N-NItrosomethylethylamIn 50mg
An N-nitrosamine; has been found at low levels in processed meat products
Cayman Chemical 2DeoxyadenosIn5OdIphos 50mg
A nucleotide diphosphate; inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase at 0.23 mM; levels are increased in erythrocytes isolated from patients with adenosine deaminase deficiency and SCID
Cayman Chemical FenoterolhydrobromIde 50mg
An analytical reference standard categorized as a β2-adrenergic receptor agonist; has been used as a performance-enhancing drug in sports doping and is banned by WADA; intended for research and forensic applications
Cayman Chemical PIcoxystrobIn 100mg
A strobilurin fungicide; active against the plant pathogenic fungus R. herpotrichoides when used at 0.75 mg/L; induces tail deformities, pericardial edema, and spine curvature in zebrafish embryos at 100 UG/L; toxic to zebrafish embryos (LC50 = 213.8 UG/L)
Cayman Chemical 5 7-DImethoxyflavon 50mg
A flavonoid with diverse biological activities; induces the production of ROS, cell cycle arrest at the G1 phase, and apoptosis in HepG2 cells at 10, 25, and 50 µM; reduces exudate volume and inhibits prostaglandin production in a rat model of carrageenan-induced pleurisy from 75-150 mg/kg; reduces rectal temperature in a rat model of yeast-induced hyperthermia; reduces serum triglyceride, total cholesterol, and LDL levels, as well as increases serum insulin levels and reduces blood glucose levels in a rat model of STZ-induced diabetes
Cayman Chemical MagnoflorIn 50mg
An alkaloid with diverse biological activities; reduces LPC-induced hemolysis in a rat erythrocyte suspension from 0.01-10 μM; induces intracellular chloride influx in neuroblastoma cells at 10 μM; reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells; improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment at 20 mg/kg
Cayman Chemical 1Stearoyl2Oleoylsnglycer 100mg
A phospholipid; has been used in the generation of LNPs for the delivery of plasmid DNA in vitro; liposomes containing 1-stearoyl-2-oleoyl-sn-glycero-3-PC and encapsulating HI-6 increase the cerebral AChE reactivation rate by 10% compared with HI-6 alone in a mouse model of soman-induced brain poisoning; has been found in WPPC
Cayman Chemical LumogalIon 100mg
A fluorescent probe for aluminum; binds to aluminum, forming a complex that displays excitation/emission maxima of 500/590 nm, respectively; has been used to detect aluminum in natural waters and human urine and serum samples by HPLC, as well as in fixed soybean roots and THP-1 cells by confocal microscopy
Cayman Chemical PnaxatrIol 100mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical RutaecarpIn 50mg
A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively); selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively); slows cancer cell growth in vitro (GI50s = 8.41-31.6 µM); induces vasodilation (0.1-10 µM) in isolated rat aorta; decreases plasma levels of caffeine in rat through CYP1A2 and CYP2E1 metabolism induction at a dose of 80 mg/kg