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Cayman Chemical Paclobutrazol 100mg
A triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins
Cayman Chemical EnzalutamIde 50mg
A non-steroidal androgen receptor antagonist (IC50 = 36 nM); reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators
Cayman Chemical RosIglItazonpotasIM salt 100mg
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Serum minus IgA/IgM/IgG human lyophilized powder | 1VL
Serum minus IgA/IgM/IgG human lyophilized powder | 1VL
Cayman Chemical 5a 6-DIhydroxycholestnol 50mg
An oxysterol metabolite of cholesterol; inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors; binds to Nav channels and decreases action potentials in hippocampal neurons in vitro at 10 µM; increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro at 5-15 µM; neuroprotective in a rat model of cerebral ischemia at 12 mg/kg ; increases latency to seizure onset and reduces severity of PTZ-induced seizures in rats; has been used as a replacement for cholesterol in the study of cholesterol binding proteins
Cayman Chemical PalmItoylDLcarnItInchLR 50mg
A long-chain acylcarnitine with both intracellular and extracellular roles; transported into mitochondria to deliver palmitate for fatty acid oxidation; alters calcium mobilization in many cell types; also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability
Cayman Chemical 1MethylhIstamInhydroCLOr 100mg
A major metabolite of histamine used as a biomarker of histaminergic system activity via CSF levels in Alzheimer’s disease patients
Cayman Chemical GnglIosIde GM1porcInam 50mg
A mixture of ganglioside GM1; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; induces apoptosis in activated T cells; found at higher levels on T cells isolated from patients with RCC; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson’s disease accumulates in neurons in ganglioside GM1 gangliosidosis
Cayman Chemical FenoterolhydrobromIde 50mg
An analytical reference standard categorized as a β2-adrenergic receptor agonist; has been used as a performance-enhancing drug in sports doping and is banned by WADA; intended for research and forensic applications
Cayman Chemical LevonrdefrIn 50mg
A vasoconstrictor; (–)-enantiomer of nordefrin; rapidly increases blood pressure and heart rate in anesthetized dogs (1-5 UG/kg); in combination with mepivacaine, increases systolic arterial blood pressure in anesthetized dogs (0.514 and 1.542 mg/kg)
Cayman Chemical NSuccInImIdylSACtylthIoac 50mg
A protein-modifying agent; introduces sulfhydryl groups to proteins; used in conjunction with the protein cross-linking reagent SMCC in the conjugation of proteins with IgG antibodies for use in ELISAs
Cayman Chemical AdenylosuccInIc ACDamonIu 50mg
A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD
Cayman Chemical LInoelaIdIc AcId 100mg
Linoelaidic acid is the all-trans fatty acid homolog of linoleic acid. Trans-fatty acids are generally not detected in raw food oils, but constitute up to 25% of the unsaturated fat in partially hydrogenated oils.{5470}
Cayman Chemical -Indoxacarb 100mg
A broad-spectrum insecticide; topical adminstration is lethal to various insects (LD50s = 0.03->7.8 ng/mg); suppresses voltage-gated sodium channel currents in rat dorsal root ganglion neurons in a concentration-dependent manner
Cayman Chemical BrImonIdIntartrate 50mg
An α2-AR agonist (Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells); selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain); lowers intraocular pressure in DBA/2J mice to control levels at 0.1% applied topically to the eye; protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia at 1 mg/kg per day