Human Sera
Cayman Chemical Chlorotoluron 100mg
A phenylurea herbicide; has been used to control growth of broad-leaved weeds in winter wheat, rye, barley, and triticale crops; genotoxic, inducing formation of chromosome aberrations and SCE in a concentration-dependent manner in CHEL liver epithelial cells; induces testicular anaplasia as well as looseness and incrassation to the basement membrane that destroys the blood-testis barrier, increases SOD activity, and degrades mitochondria in mice (625-5,000 mg/kg); reduces food intake and body weight and induces hemolytic anemia, hemosiderosis of the spleen, and brown atrophy in dogs (9,200 ppm)
Cayman Chemical CepharnthIn 100mg
A biscoclaurine alkaloid that can decrease the fluidity of biological membranes; exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models
Cayman Chemical IsorhynchophylIn 50mg
An oxindole alkaloid with diverse biological activities; inhibits decreases in cell viability and increases in intracellular levels of ROS and MDA induced by Aβ (25-35) in PC12 cells; attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation at 30 and 100 μM; decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 μM); induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel™ assay in HepG2 cells; decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of monocrotaline-induced pulmonary arterial hypertension at 0.1% in the diet
Cayman Chemical AlosetronhydrochlorIde 50mg
A 5-HT3 receptor antagonist (Kis = 0.3 and 0.4 nM for the rat cortical and human recombinant receptors, respectively); selective for 5-HT3 over 5-HT2 and 5-HT1A receptors (Kis = 6.3 and >100 µM, respectively), as well as α1-, β1-, and β2- adrenergic, M1, M2, and M3 muscarinic, GABAA, dopamine D2, and nicotinic receptors at 10 μM; inhibits 5-HT-induced depolarization of isolated rat vagus nerve at 0.3-10 nM; reduces wrap restraint stress-induced defecation and the number of abdominal muscle contractions in a rat model of IBS-D at 0.1 mg/kg
Cayman Chemical LumogalIon 100mg
A fluorescent probe for aluminum; binds to aluminum, forming a complex that displays excitation/emission maxima of 500/590 nm, respectively; has been used to detect aluminum in natural waters and human urine and serum samples by HPLC, as well as in fixed soybean roots and THP-1 cells by confocal microscopy
Cayman Chemical SRT 3025hydrochlorIde 50mg
A SIRT1 activator; increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse BMDMs at 2 µM; inhibits proliferation of SU.86.86 cells (IC50 = 0.98 µM); decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet at 3.18 g/kg
Cayman Chemical DaunorubIcInhydrochlorIde 50mg
An antitumor antibiotic that induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia cells at 0.2-1 μM; triggers a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK
Cayman Chemical 5Cyno2 3dI ptolyltetra 50mg
A redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms; readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal (absorption maximum at 450 nm)
Cayman Chemical DefensamIde 50mg
An SPHK1 activator; increases S1P levels in primary human keratinocytes but does not affect S1P lyase activity in the same cells at 100 µM; increases protein levels of LL-37 in primary human keratinocytes at 100 µM; inhibits invasion of S. aureus into murine skin ex vivo; has been used as an intermediate in the synthesis of sinuxylamide A as well as compounds with anticancer and antibacterial activities
Cayman Chemical PRfluorohexnsulfonIc ACD 100mg
A perfluoroalkyl substance; activates PPARα in a reporter assay using COS-1 cells expressing the human or mouse receptor from 5-100 µM; has been found in landfill leachate and sea and river water
Cayman Chemical GBR 12909hydrochlorIde 50mg
A potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.
Cayman Chemical DImaprIthydrochlorIde 50mg
A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner
Cayman Chemical BupIvacaInhydrochlorIde 50mg
An analytical reference standard categorized as a local anesthetic; intended for use in analytical forensic applications
Cayman Chemical 7-MethylgunIn 100mg
A metabolite of the natural purine base that is generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods; carcinogenic biomarker for cigarette smoking that is detectable in urine
Cayman Chemical Domperdon 50mg
A dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor); selective for dopamine D2 over D3 receptors (Ki = 9.5 nM); inhibits dipropyl dopamine-induced femoral vasodilation in dogs at 0.5-5 μg/kg; prevents dopamine-induced decreases in pentagastrin-induced gastric antral motility in dogs at 0.5 mg/kg; inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.); increases serum levels of prolactin in male rats