Human Sera
Cayman Chemical DodecylphosphocholIn-d38 50mg
An internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS
Cayman Chemical TrIazavIrIn 100mg
An antiviral agent; inhibits lung viral accumulation in a mouse model of H5N1 influenza A infection at 1 mg/kg; inhibits platelet aggregation in a rat model of LPS-induced hypercytokinemia at 20 mg/kg
Cayman Chemical 2DeoxygunosIn5OtrIpho 100mg
A nucleoside triphosphate; has commonly been used in PCR reaction mixtures as a substrate for DNA synthesis by DNA polymerases; can be oxidized to 8-hydroxy-dGTP and 8-oxo-7,8-GTP, which can be misincorporated into DNA
Cayman Chemical Prdopdn 50mg
A σ1 receptor ligand and dopaminergic stabilizer; binds to the σ1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively); increases striatal DOPAC levels and locomotor activity, as well as inhibits amphetamine-induced locomotor activity, in rats at 100 µmol/kg; improves motor function and reduces striatal mHtt aggregates in the R6/2 mouse model of Huntington’s disease at 5 or 6 mg/kg; prevents muscle atrophy and the loss of innervated neuromuscular junctions in the SOD1-G93A mouse model of ALS at 30 mg/kg
Cayman Chemical IrInotecnhydrochLRIde hyd 50mg
A derivative of the alkaloid camptothecin that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I; demonstrates a broad spectrum of antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors
Cayman Chemical R S-3 5-DHPG 100mg
An agonist of group I mGluRs; induces phosphoinositol hydrolysis in MCB3901 cells expressing human mGluR1a and mGluR5a; potentiates NMDA-induced depolarizations in rat hippocampal slices at 10 µM; intrathecal administration increases mean blood pressure in anesthetized rats at 300 nmol/animal; induces seizures in rats at 1.5 µmol/animal, i.c.v.
Cayman Chemical mthyl DIethyldIthIocrbmt 50mg
An active metabolite of disulfiram; inhibits liver low Km ALDH in rats (ID50 = 15.5 mg/kg); decreases MAP and increases heart rate during ethanol challenge in rats at 20.6 mg/kg
Cayman Chemical 4-fluoro BZPhydrochlorIde 50mg
A substituted benzylpiperazine with a potential for abuse; intended for forensic and research applications
Cayman Chemical 5a-ndrostn-3-ol 50mg
A steroidal androgen; binds to the androgen receptor in a cell-free assay (IC50 = 1.7 µM); activates PXR in HepG2 cells in a reporter assay (EC50 = 0.8 µM); inhibits the androst-4-ene-3,17-dione hydroxylase activities of 16α- and 6β-hydroxylase but not 16β- or 7α-hydroxylase (IC50s = 70, 110, >150, and >150 µM, respectively); decreases testis weight and sperm production in mice at 30 mg/kg
Cayman Chemical IsoquercetIn 50mg
A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 UG/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg
Cayman Chemical PyrIbencarb 100mg
A carbamate fungicide; inhibits the production of aflatoxins in A. parasiticus (IC50 = 0.43 µM); inhibits wild-type B. cinerea and strobilurin-resistant B. cinerea mitochondrial complex II (IC50s = 0.079 and 5.1 µM, respectively) and wild-type B. cinerea mitochondrial complex III (IC50 = 0.023 µM); prevents and reduces B. cinerea lesion development on cucumber seedlings at 3 UG/ml; inhibits B. cinerea mycelial growth (EC50 = 0.006 UG/ml)
Cayman Chemical RosmarInIc AcId 100mg
Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 UG/ml.{4778} Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.{4407,4408} Formation of 5-HETE and LTB4 from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.{4706}
Cayman Chemical LagochIlIn 100mg
A polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb; intended for research and forensic purposes
Cayman Chemical TerbuthylazIn 50mg
A triazine herbicide; active against a variety of broadleaf and grass weeds in combination with S-metolachlor; has been found in surface groundwater and soil samples