Human Sera
Cayman Chemical Guafensn 50mg
An analytical reference standard categorized as an expectorant; intended for use in analytical forensic applications
Cayman Chemical TMPyP4tosylate 100mg
A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo
Cayman Chemical ClorgylInhydrochlorIde 50mg
A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively); also inhibits the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM)
Cayman Chemical olna ntdysntca Consn 100mg
A steroidal alkaloid; active against a variety of Gram-positive and Gram-negative bacteria (MICs = 15.6-1,000 UG/disc in agar diffusion assays), E. histolytica, and P. falciparum schizonts (IC50 = 1.9 UG/ml); inhibits replication of the coronaviruses HCoV-OC43, HCoV-NL63, MERS-CoV, and MHV-A59 in infected cells (EC50s = 2.34, 10.75, 4.98, and 11.46 µM, respectively); a histamine H3 receptor antagonist (Kis = 5.37 and 12.3 nM for the human and rat receptors, respectively); reduces parasitemia in P. berghei-infected mice at 10 mg/kg
Cayman Chemical R-Lnsoprazole 100mg
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM
Cayman Chemical IsoImperatrIn 50mg
A natural furanocoumarin that inhibits CYP1A activity, in particular blocking hepatic EROD activity; also induces the expression of GSTα by activating Nrf2
Cayman Chemical RnolazInhydrochlorIde 100mg
A piperazine derivative with cardioprotective activity; reduces INa in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM); reduces IKr in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively); reduces clofilium-induced prolongation of the QTc interval and TdP in rabbits at 480 μg/kg per min; reduces interstitial collagen deposition as well as ANP, CTGF, BNP, and MMP-2 mRNA levels, and prevents left ventricular dilation in a mouse model of doxorubicin-induced cardiotoxicity
Cayman Chemical PentagastrIn 50mg
A synthetic polypeptide and CCK2 receptor agonist; binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively); increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively); increases histidine decarboxylase activity in mucous and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM); induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM); increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively)
American Research Products Inc Mouse Complement C1q tumor nec
Mouse Complement C1q tumor necrosis factor-related protein 3 (C1QTNF3) ELISA kit from CUSABIO Detection Range 3 12 ng/mL-200 ng/mL Sensitivity 0 78 ng/mL Sample serum plasma tissue homogenates Method Sandwich
Cayman Chemical Bivalirudin 50MG
A thrombin inhibitor (Kis = 2.56 and 1.84 nM for α- and ζ-thrombin, respectively); selective for α- and ζ-thrombin, lacking activity at trypsin and γ-thrombin at a >1,000-fold excess; inhibits α-thrombin-stimulated activation of the clotting factors Factor X, Factor V, and prothrombin in contact-activated plasma; reduces platelet deposition in a rat carotid endarterectomy model in a dose-dependent manner
Cayman Chemical Buparvaquon 100mg
An inhibitor of cytochrome bc1 in the parasites T. annulata and T. parva (in vitro EC50 of 1.5 x 10-8 M and 6.1 x 10-10 M, respectively)
Cayman Chemical CurcumaZerumbon 50mg
A natural monocyclic sesquiterpene that potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC50 = 140 nM); inhibits SHH signaling and induces apoptosis in cancer cell lines
Cayman Chemical PalonsetronhydrochlorIde 50mg
A 5-HT3 receptor antagonist (Ki = 0.04 nM); selective for 5-HT3 over 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kis = ≥15.85 μM for all), as well as a panel of additional neurotransmitter receptors; inhibits 5-HT-induced contraction in isolated guinea pig ileum; inhibits cisplatin-induced emesis in ferrets (ID50 = 1.1 μg/kg, i.v.); inhibits emesis induced by cisplatin, dacarbazine, actinomycin D, and mechlorethamine in dogs (ID50s = 1.9, 4.1, 4.9, and 4.4 μg/kg, respectively)
Cayman Chemical DAPTAacetate 50mg
A CCR5 receptor antagonist; inhibits CD4-dependent binding of HIV-1Ba-L and HIV-1CM235 gp120 envelope proteins to CCR5 (IC50s = 0.06 and 0.32 nM, respectively); reduces marble burying and repetitive behavior, as well as decreases brain levels of IL-6, IL-9, and IL-17A, in the BTBR T+ Itpr3tf/J mouse model of ASD at 0.1 mg/kg; reduces LPS-induced microglial activation and astrocyte hypertrophy in the dentate gyrus in a rat model of chronic neuroinflammation
Cayman Chemical LauroylLcarnItInchLRIde 50mg
An acylcarnitine and a quaternary ammonium-containing cationic surfactant; has been used to permeabilize porcine enterocytes for delivery of the polar fluorescent probe lucifer yellow