Human Sera
Cayman Chemical 1Stearoyl2Oleoylsnglycer 100mg
A phospholipid; has been used in the generation of LNPs for the delivery of plasmid DNA in vitro; liposomes containing 1-stearoyl-2-oleoyl-sn-glycero-3-PC and encapsulating HI-6 increase the cerebral AChE reactivation rate by 10% compared with HI-6 alone in a mouse model of soman-induced brain poisoning; has been found in WPPC
Cayman Chemical PnaxatrIol 100mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical BARICITINIB 50MG
A JAK1 and JAK2 inhibitor (IC50s = 0.0059 and 0.0057 µM, respectively); selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and Chk2 (IC50s = >0.4, 0.053, >10, and >1 µM, respectively); inhibits IL-6-induced phosphorylation of STAT3 in isolated human PBMCs and rat whole blood (IC50s = 0.044 and 0.128 µM, respectively); reduces disease severity in a type II collagen-induced mouse model of arthritis at 3 and 10 mg/kg; decreases lung macrophage infiltration and disease severity in rhesus monkeys infected with SARS-CoV-2 at 4 mg/animal
Cayman Chemical 4-DemethylpodophylotoxIn 50mg
A lignan; inhibits the assembly of isolated chicken brain tubulin (IC50 = 0.5 µM) and the proliferation of LNCaP and PC3 cells (IC50s = 0.056 and 0.082 µM, respectively)
Cayman Chemical RIcInlaIdIc AcId 100mg
An LTB4 receptor antagonist (Ki = 2 µM); inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s = 10 and 7 µM, respectively); inhibits bronchoconstriction induced by LTB4 in rats by 46%
Cayman Chemical MaytnsInol 100mg
An ansa macrolide; inhibits polymerization and induces depolymerization of bovine brain tubulin (EC50s = 12 and 43 µM, respectively); inhibits sea urchin egg mitosis at 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 UG/ml)
Cayman Chemical PF-04691502 50mg
A PI3Kα, -β, -δ, -γ, and mTOR inhibitor (Kis = 1.8, 2.1, 1.6, 1.9, and 16 nM, respectively, for the human enzymes); decreases the proliferation of BT-20, SKOV3, and U87MG cells (IC50s = 313, 188, and 179 nM, respectively); inhibits capillary tube formation by, and migration of, HUVECs at 2.5 and 5 µM; induces cell cycle arrest at the G1 phase in U87MG cells at 500 and 1,000 nM; decreases tumor volume in NCI H1650 and H1975 NSCLC mouse xenograft models at 10 mg/kg per day
Cayman Chemical PF-670462hydrochlorIde 50mg
A potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively); less effectively inhibits a wide variety of related or common kinases; disrupts circadian rhythms in cells and animals; blocks the locomotor response to amphetamines in mice
Cayman Chemical PerfluoroctnsulfonamIde 100mg
A perfluoroalkyl substance; induces hepatic macrophage and neutrophil accumulation and fibrosis in zebrafish larvae when administered in tank water from 0.1-100 UG/L; has been found in municipal wastewater networks
Cayman Chemical MEGsulfate 50mg
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Cayman Chemical Cndesartn 100mg
An AT1 receptor antagonist (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively); selective for AT1 over AT2 receptors (Ki = 26,500 nM for the recombinant human AT2 receptor); inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats (ID50 = 0.033 mg/kg, i.v.)
Cayman Chemical DaunorubIcInon 50mg
An aglcyone form of the antitumor antibiotic daunorubicin; has been used as a starting material in the synthesis of anticancer agents
Cayman Chemical 2-AmInopurInhydrochlorIde 50mg
A fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics, such as studies of base stacking interactions and DNA base flipping; ex/em = 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence; inhibits PKR
Cayman Chemical DeslorelInacetate 50mg
A peptide agonist of GnRH; binds to GnRHR (Ki = 0.1 nM); decreases testicular volume, semen volume, sperm motility, and total sperm count, as well as increases the percentage of abnormal sperm, in dogs via a subcutaneous implant at 3, 6, and 12 mg per animal; decreases disease severity and plasma levels of estradiol, 17-hydroxyprogesterone, and androstenedione in ferrets with ACD at 3 mg/implant per animal; suppresses ovulation and estrus in cats at 4.7 mg/implant per animal
Cayman Chemical LevetIracetam 50mg
An antiepileptic agent; binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM); suppresses seizures in fully kindled rats