Human Sera
Cayman Chemical RhodamIn 123chlorIde 100mg
A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp; also accumulates within mitochondria and can inhibit oxidative phosphorylation; ex/em = 507/529 nm
Cayman Chemical TetrahydroharmIn 50mg
A fluorescent indole alkaloid extracted from B. caapi that inhibits MAO-A and MAO-B with much weaker potency (IC50s = 74 nM and >100 μM, respectively) compared to its companion harmala alkaloids: harmaline (IC50s = 2.5 nM and 25 μM, respectively) and harmine (IC50s = 2 nM and 20 μM, respectively)
Cayman Chemical MonbromobImn 50mg
A thiol-reactive fluorogenic probe; used to evaluate or quantify a variety of compounds containing reactive sulfur or thiol groups, including H2S, glutathione, proteins, and nucleotides
Cayman Chemical TemocaprIlhydrochlorIde 50mg
A prodrug form of temocaprilat; prevents impairment of acetylcholine-induced relaxation in aortic rings isolated from diabetic rats in a model of streptozotocin-induced diabetes; inhibits the angiotensin I-induced pressor response in normotensive rats at 0.1, 0.3, and 1 mg/kg; prevents coronary vascular remodeling induced by L-NAME in rats at 0.1 mg/ml in the drinking water; reduces plasma glucose levels in a KKAy mouse model of type 2 diabetes at 1 mg/kg
Cayman Chemical VardenafIlhydroCLOrID hyd 50mg
An inhibitor of PDE5 (IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM); selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively); improves erectile dysfunction in a rat model of acute arteriogenic erectile dysfunction; reduces the latency to mount and increases the frequency of mounting in mice after chronic treatment at 2 mg/kg for five weeks
Cayman Chemical Ro 25-6981maleate 50mg
A potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50 = 9 nM); displays neuroprotectant effects in cortical neurons in vitro (IC50 = 0.04-0.4 μM)
Cayman Chemical QuInacrInhydroCLOrID hyd 100mg
An acridine compound with diverse biological activities and cell labeling properties; has anti-protozoal properties; prevents misfolding of prion protein (EC50 = 0.3 μM); blocks voltage-dependent sodium channels (IC50 = 3.3 μM); inhibits aldehyde oxidase (IC50 = 3.3 μM); antagonizes the riboflavin-binding protein (Ki = 6.7 μM); inhibits P-glycoprotein (EC50 = 14.4 μM); stains DNA and RNA in fixed cells with ex/em = 436/525 nm, respectively; labels acidic vesicles, such as lysosomes, in live cells for long-term imaging with ex/em = 458/470-580 nm, respectively
Cayman Chemical MaleIMDoACtIc ACD Nhydrox 50mg
A crosslinking reagent that contains NHS ester- and maleimide-reactive groups at the opposite ends of a 4.4 Å spacer arm; used for sequential, two-stage conjugation with amine and sulfhydryl functional groups in the preparation of protein-hapten or protein-protein conjugates
Cayman Chemical AceclIdInhydrochlorIde 100mg
An agonist of muscarinic receptors (EC50 = 1.8-17 µM for human M2)
Cayman Chemical pIodoClonIdInhydrochLRI 50mg
A partial agonist of the α2-adrenergic receptor, minimally inhibiting adenylate cyclase through this Gi protein-coupled receptor although it binds avidly (Ki = 1.0 nM); potentiates platelet aggregation by ADP (EC50 = 1.5 µM) and inhibits epinephrine-induced aggregation (IC50 = 5.1 µM)
Cayman Chemical 4amIno1 8NaphthalImIde 100mg
An inhibitor of PARP (IC50 = 180 nM); blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation
Cayman Chemical NBQXsodIum salt 100mg
A water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively); does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM)
Cayman Chemical ArnbIae radIx ShIkonIn 50mg
A naturally occurring naphthoquinine; increases glucose uptake by adipocytes and inhibits PTEN activity; inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2; inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication; reduces joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis