Human Sera
Cayman Chemical AsoxImechlorIde 50mg
An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning
Cayman Chemical 17phenl trInor ProstglndI 50mg
An F-series prostaglandin and an FP receptor agonist; induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM); ocular administration reduces IOP in normotensive dogs and ocular hypertensive monkeys at 0.03% w/v
Cayman Chemical 2-methoxy Estron 50mg
An active metabolite of estrone; inhibits proliferation of isolated bovine brain-derived capillary endothelial cells (IC50 = 11.5 µM); increases levels of 6-keto PGF1α in HUVECs at 0.001, 0.01, and 0.1 µM; reduces ovariectomy-induced increases in serum cholesterol in rats at 0.5 mg/kg
Cayman Chemical PolIumosIde 100mg
A phenylethanoid glycoside; scavenges DPPH and ABTS radicals (IC50s = 10.9 and 19.9 µM), as well as inhibits the activity of PKCα (IC50 = 24.4 µM), in cell-free assays); reduces LPS-induced production of TNF-α and IL-6 in RAW 264.7 cells from 12.5-100 µM; decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1, 1, or 10 µM
Sino Biological Recombinant Human IGF1R Protein (ECD, His Tag), Endotoxin-Free
A DNA sequence encoding the extracellular domain (Met1-Asn932) of human IGF1R (NP_000866.1) was expressed with a C-terminal polyhistidine tag.
Cayman Chemical ttramthyl NordIhydroguaIr 50mg
A derivative of nordihydroguaiaretic acid; inhibits Tat-regulated HIV promoter transactivation in COS-1 cells in a reporter assay (IC50 = 11 µM); inhibits replication of acyclovir-sensitive and -resistant strains of HSV-1 in Vero cells (IC50s = 5.6 and 8.9 µM, respectively); induces cell cycle arrest at the G1/G0 phase in A375 cells at 50 µM; inhibits tumor growth in an A375 mouse xenograft model at 250 mg/kg; inhibits tumor growth in a B16 murine melanoma model at 166 mg/kg
Cayman Chemical DehydroevodIamInhydrochLR 50mg
An alkaloid with diverse biological activities; inhibits LPS-induced secretion of PGE2 in RAW 264.7 mouse macrophages at 30 μM; reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae from 0.1-0.3 μM; decreases MAP by ~30% in rats at 10 mg/kg; inhibits amyloid-β (25-35)-induced amnesia and increases latency to step-through in a passive avoidance test in mice at 1.5 mg/kg
Cayman Chemical MItoxntronhydrochlorIde 50mg
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase (IC50s = 5.3 and 3.8 μM, respectively); intercalates DNA in a cell-free assay at 2 µM; inhibits DNA synthesis and induces DNA-protein crosslinks in vitro; inhibits the growth of K562 and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively); inhibits HIV-1 integrase (IC50 = 3.8 μM); inhibits the membrane fusion of a mixed population of HEK293T cells expressing either ACE2 or the extracellular domain SARS-CoV-2 spike glycoprotein; inhibits the entry of SARS-CoV-2 into Vero E6 cells at 0.2 µM
Cayman Chemical MItoBloCK-10 50mg
A mitochondrial protein import inhibitor; inhibits the import of cytochrome c1 into the mitochondrial intermembrane space in yeast cells at 100 µM; inhibits migration and invasion of, and induces apoptosis and cell cycle arrest at the G1 phase in, primary human bladder cancer cells at 25 µM; induces mitochondrial depolarization, decreases ATP levels, and increases ROS in primary human bladder cancer cells; decreases tumor volume in a PDX mouse model of bladder cancer at 20 mg/kg every other day; intravitreal administration reduces SOD activity and increases TBARS levels and acellular capillary numbers in mouse retina at 0.25 nM/eye; induces dorsal curvature and cardiac apoptosis in zebrafish embryos at 10 µM
Cayman Chemical AzoxystrobIn 100mg
A broad-spectrum fungicide (LC95s = 20 = 2.9 µM); disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of ROS in zebrafish larva at 0.1-100 UG/L; inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 UG/ml after 48 hours); reduces tumor growth at 40 mg/kg per day
Cayman Chemical CeftIzoxImesodIum salt 100mg
A cephalosporin antibiotic; active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, and S. epidermidis (IC50s = 1.56, ≤0.025, and 0.78 UG/ml, respectively), as well as clinical isolates of the Gram-negative bacteria E. coli, K. pneumoniae, and P. mirabilis (IC50s = 0.1, ≤0.025, and ≤0.025 UG/ml, respectively); protective against S. aureus, E. coli, P. mirabilis, or P. vulgaris infection in mice (ED50s = 4.03, 0.02, 0.255, and 0.038 mg/kg, respectively)
Cayman Chemical RepaglInIde 100mg
An ATP-dependent potassium channel blocker (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2); lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively)