Human Sera
Cayman Chemical TrIGalNAc OAc3trIfluoroac 50mg
An internal standard for the quantification of linoleic acid by GC- or LC-MS
Cayman Chemical AcoramIdIshydrochlorIde 50mg
An ionizable cationic lipidoid has been used in the generation of LNPs LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce the expression of Hsp47 in activated NIH3T3 mouse liver fibroblasts and primary mouse hepatic stellate cells LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce CCl4-induced liver fibrosis in mice
Cayman Chemical CIcloprofen 50mg
An alkaloid active against P. falciparum (IC50 67.6 Ug/ml) decreases proliferation of various cancer cell lines (IC50s 6.11-80.99 UM)
Cayman Chemical GYKI 52466hydrochlorIde 50mg
An analytical reference standard categorized as an arylcyclohexylamine induces discriminative stimulus effects in rats comparable with those induced by PCP intended for research and forensic applications
Cayman Chemical SB-399885hydrochlorIde 50mg
A TRPV1 antagonist (Ki 72 nM for the recombinant guinea pig channel) inhibits capsaicin- or pH decrease-induced guinea pig TRPV1 channel activation (IC50s 58 and 470 nM respectively) reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs at 20 mg/kg reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain at 30 mg/kg decreases capsaicin-induced production of CGRP and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine
Cayman Chemical SRT 3025hydrochlorIde 50mg
A monosaccharide intermediate of the hexosamine biosynthetic pathway binds the GlmS riboswitch (Ki 380 UM) and inhibits GlmS production and decreases D-GlcN-6-P levels precursor in the biosynthesis of UDP-GlcNAc
Cayman Chemical N-NItrosonrnIcotIn 50mg
A heterobifunctional PEGylated linker contains a reactive NH2 end group as well as an azide functional group for use in click chemistry reactions has been used as a linker in the synthesis of bivalent mTOR inhibitors
Cayman Chemical 2DeoxycytIdIn5OtrIphos 50mg
An atypical antipsychotic and dopamine D2 receptor antagonist (Ki 0.2 UM) selective for the D2 receptor over a panel of 33 receptors neurotransmitter transporters and ion channels at 10 UM but does inhibit the σ receptor (Ki 0.065 UM) increases striatal DOPAC and HVA levels in rats from 2-20 Umol/kg inhibits apomorphine-induced stereotypy and hyperactivity in rats (ED50s 5.6 and 0.8 Umol/kg respectively)
Cayman Chemical Hbscus vtfolus Gosypn 100mg
A dual inhibitor of Cdk8 and Cdk19 (IC50s 0.6 and 4.3 nM respectively) induces Foxp3 expression in isolated mouse naïve T cells at 1 UM alone or synergistically with TGF-B decreases ear edema and induces production of Foxp3 Tregs in mice at 30 mg/kg reduces disease severity in a mouse model of EAE
Cayman Chemical Arnba euchroma Shkalkn 50mg
A peptide ETB receptor agonist selectively binds to ETB receptors (Ki 16 pM) over ETA receptors (IC50 1.9 UM) induces contractions of isolated guinea pig trachea from 0.01-1 UM reduces MAP in normotensive rats and SHRs and diminishes the transient depressor response in SHRs at 1 nmol/kg reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia improves Ab-induced spatial memory deficits in a rat model of Alzheimers disease
Cayman Chemical NCbzGlyProGlyGlyProAla 50mg
An alkaloid with diverse biological activities inhibits 5-HT reuptake by OCT2 and dopamine reuptake by OCT3 (IC50s 0.137 and 0.354 UM respectively for human recombinant transporters) as well as reduces dopamine 5-HT and norepinephrine reuptake in mouse brain synaptosomes decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress at 1.5 and 3 mg/kg reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain at 10 mg/kg
Cayman Chemical HArgGlyAspCysOHtrIfluo 50mg
A platelet aggregation inhibitor inhibits ADP- collagen- or epinephrine-induced platelet aggregation in isolated human platelets (IC50s 730 92 and 3.4 UM respectively) inhibits arachidonic acid-induced platelet aggregation and TXA2 production in isolated rat platelets (IC50s 3.3 and 32.8 UM respectively) reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner decreases thrombus weight in a rat model of arterio-venous shunt thrombosis at 50 mg/kg increases survival in a mouse model of septicemia induced by LPS at 10 and 20 mg/kg
Cayman Chemical 5bromo4chLRo3Indolyl 50mg
A fluorogenic substrate for trypsin cathepsin B and cathepsin H AMC is released upon enzymatic cleavage by trypsin cathepsin B or cathepsin H and its fluorescence can be used to quantify trypsin cathepsin B and cathepsin H activity ex/em 340-360/440-460 nm respectively
Cayman Chemical Ocmum gratsmum Pprton 100mg
A modified form of AB42 that is citrullinated at arginine 5 exhibits increased transient formation of soluble oligomers and decreased rate of fibril formation compared with unmodified AB42 forms fibrils composed of parallelBsheets
Cayman Chemical MaduramIcInamonIum salt 100mg
A tricyclic antidepressant binds to the norepinephrine and 5-HT transporters (Kd 1.41 and 19.6 nM respectively) binds to histamine H1 muscarinic acetylcholine and a1-adrenergic receptors (Kds 25 25 and 130 nM respectively) inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s 12 and 0.55 M respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 5.5 M) inhibits food-induced cataplexy in narcoleptic dogs at 1 mg/kg i.v.