Human Sera
Cayman Chemical MosaprIdecItrate 50mg
A triterpenoid with diverse biological activities active against P falciparum (IC50 6 5 g/ml) and M tuberculosis (MIC 25 g/ml) in vitro as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S aureus (MICs 128-512 and 8-512 g/ml respectively) inhibits dengue virus NS5 RNA-dependent RNA polymerase (IC50 6 1 M) and inhibits dengue virus type 2 replication by 20 and 55 at 5 and 10 g/ml respectively inhibits growth of leukemia melanoma neuroblastoma and normal fibroblast cell lines (IC50s 1 1-4 9 9 6-10 6 7 5-8 8 and 18 5 M respectively)
Cayman Chemical GR127935hydrochlorIde 50mg
An internal standard for the quantification of safinamide by GC- or LC-MS
Cayman Chemical RupatdInfumarate 50mg
A metabolite of raloxifene formed from raloxifene via UGT1A1 and UGT1A8 binds to the estrogen receptor (IC50 290 nM)
Cayman Chemical 8- 3-ChlorostyrylcaffeIn 50mg
A bivalent Smac mimetic and IAP antagonist binds to IAP1 and XIAP (Kds 0 46 and 1 3 nM respectively) induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells at 5 M induces NF-KB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells at 4 M enhances radiosensitization and increases apoptosis in HCC193 and H460 NSCLC cell lines induces cell death in a panel of 40 primary patient-derived BCP-ALL samples at 1 M increases survival and time to relapse in a high-risk BCP-ALL PDX mouse model
Cayman Chemical ClInofIbrate 50mg
A caspase-1 fluorogenic substrate upon enzymatic cleavage AMC is released and its fluorescence can be used to quantify enzyme activity ex/em 340-360/440-460 nm respectively
Cayman Chemical ResorufInsodIum salt 100mg
A chromene with anti-juvenile hormone activity inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach corpora allata at 1 mM inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females at 8 g/cm2 as a coating in Petri dish induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at 0 4 and 0 7 g/cm2 inhibits ovarian development in various insects including milkweed bugs cotton stainers apple maggots and Mexican bean beetles inhibits production of the trichothecene mycotoxin 3-ADON in F graminearum (IC50 1 2 M) without inhibiting fungal growth
Cayman Chemical AcetylDLcarnItInchLRIde 50mg
For screening a variety of immuno-oncology associated compounds contains more than 90 cancer and immunology-associated compounds as 10 mM stock solutions in DMSO includes a variety of immuno-oncology target modulators including but not limited to adenosine CCR CXCR and TLR agonists and antagonists BTK PI3K and BRAF inhibitors PD-1/PD-L1 interaction inhibitors and HDAC inhibitors
Cayman Chemical CarbendazIm 100mg
A coumarin with diverse biological activities decreases secretion of HBsAg from Huh7 cells transfected with HBV DNA by 70 at 20 Ug/ml induces BMP2 production in and differentiation of MG-63 and hFOB osteoblast-like cells induces vasorelaxation in isolated rat blood vessels ileum corpus cavernosum and trachea inhibits migration and invasion of MCF-7 MDA-MB-231 H1299 and A549 cancer cells in vitro increases survival in an SMMC-7721 hepatocellular carcinoma mouse xenograft model hepatoprotective in mouse models of concanavalin A-induced hepatitis and alcoholic fatty liver disease
Cayman Chemical 5 Hydroxymethyl2deoxyurI 50mg
An HDAC inhibitor with structural similarities to mocetinostat MS-275 and JNJ-26481585
Cayman Chemical LInaglIptIn 100mg
An endogenous mGluR2 and mGluR3 agonist implicated in the pathophysiology of schizophrenia induces gametogenesis of P falciparum
Cayman Chemical 4NItrophenyl DCelobIosId 50mg
An Mcl-1 inhibitor (Ki 0 19 nM) induces cell death in multiple myeloma leukemia and lymphoma cell lines (IC50s via mitochondrial apoptosis acts synergistically with trametinib lapatinib PLX4032 and erlotinib to reduce proliferation of SK-MEL-2 BT474 A2058 and PC9 cells respectively reduces tumor volume in a MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner
Cayman Chemical BopIndololmalonate 100mg
A byproduct in the synthesis of ethylene and propylene glycol has been found in municipal drinking water in the United States and waterways in the Netherlands where it is considered a POP mutagenic in the S typhimurium strains TA 1535 and TA 100
Cayman Chemical GuvacInhydrochlorIde 100mg
A SERM that evokes tissue-dependent effects similar to that of tamoxifen
Cayman Chemical DIflubenzuron 50mg
Produced by selective hydrolysis of the terminal saccharide unit of ivermectin inhibits nematode larval development
Cayman Chemical 2propyl4PentenoIc AcId 100mg
A small molecule inhibitor that specifically kills cells with APC (IC50 70 nM) but spares cells with wild-type APC