Human Sera
Cayman Chemical PropIonylLcarnItInchlorI 100mg
A carnitine derivative; increases the basal release of PGE2 and 6-keto prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils; increases the basal release of thromboxane B2 in non-neutrophil-contaminated carrageenan-stimulated isolated rat peritoneal cells; reduces the production of ROS and decreases NOX2, NOX4, and ICAM-1 expression in HUVECs; increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia at 10 mg per animal
Cayman Chemical TndospIron 50mg
A 5-HT1A partial agonist; selectively binds to 5-HT1A receptors (Ki = 0.027 µM) over 5-HT2, 5-HT1B, 5-HT1C, and 5-HT1D receptors (Kis = 1.3, >100, 2.6, and >100 µM, respectively), as well as α1-ARs, α2-ARs, β-ARs, and dopamine D1 and D2 receptors (Kis = 1.6, 1.9, >100, 1.7, and 41 µM, respectively); reduces forskolin-induced adenylate cyclase activity in rat hippocampal homogenates from 0.1-100 µM; reduces immobility time in the forced swim test in mice at 10 and 20 mg/kg; increases food intake and overall survival, as well as decreases body weight loss in a Yoshida hepatoma rat model of cancer cachexia
Cayman Chemical 2-O-MethyladenosIn 50mg
An analog of adenosine used to prepare nucleoside derivatives as inhibitors of viral RNA translation and replication
Cayman Chemical SunItInIbmalate 50mg
A multi-kinase inhibitor; inhibits FLK1 (Ki = 9 nM), PDGFRβ (Ki = 8 nM), and FLT3; at least 10-fold selective for FLK1 and PDGFRβ over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl, and Src; inhibits VEGF-dependent FLK1 and PDGF-dependent PDGFRβ phosphorylation (IC50s = 10 and 10 nM, respectively); inhibits phosphorylation of FLT3 and FLT3-ITD (IC50s = 250 and 50 nM, respectively); decreases VEGF- and FGF-induced proliferation of HUVECs; IC50s = 30 and 700 nM, respectively); reduces tumor growth in a variety of mouse xenograft models at 20-80 mg/kg per day
Cayman Chemical 2-MethoxyestradIol 50mg
A natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol; has anticancer agent activity as an angiogenesis inhibitor via the HIF-1α pathway; levels are significantly lower in women with severe pre-eclampsia
Cayman Chemical ImIdaprIlhydrochlorIde 50mg
A prodrug form of imidaprilat; inhibits swine renal cortex ACE activity in vitro (IC50 = 9.9 µM); inhibits the angiotensin I-induced pressor response in normotensive rats; decreases blood pressure in spontaneously hypertensive and 2K-1C renal hypertensive rats at 2 mg/kg; decreases stroke incidence and increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet; reduces urinary albumin excretion in a mouse model of streptozotocin-induced diabetes at 5 mg/kg
Cayman Chemical tremIfencItrate 50mg
A SERM that evokes tissue-dependent effects similar to that of tamoxifen
Cayman Chemical DIhydrophytol 100mg
An intermediate in the biosynthesis of phytanic acid; produced from phytol in the rumen of cattle
Cayman Chemical TerbutalIn 100mg
A β2-adrenergic receptor agonist; an active metabolite of bambuterol; binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively); selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values; inhibits airway obstruction induced by methacholine or LTD4 in anesthetized guinea pigs
Cayman Chemical LIxIsenatIdeacetate 50mg
A GLP-1R agonist; binds to CHO-K1 cells expressing human GLP-1R (IC50 = 1.4 nM); inhibits Il-1β- and IFN-γ-induced apoptosis in INS-1 rat pancreatic β-cells at 100 pM; lowers blood glucose levels in an OGTT (ED50 = 0.021 nmol/kg) and decreases blood HbA1c levels in db/db mice
Cayman Chemical 2EthylmethcathInonhydroch 50mg
A potential stimulant/entactogen designer drug of the amphetamine, phenethylamine, and cathinone chemical classes; intended for forensic purposes
Cayman Chemical 2MethoxymethcathInonhydro 50mg
A positional isomer of methedrone, having the methoxy group at the 2 rather than the 4 position; intended for forensic and research applications