Human Sera
Cayman Chemical ToltrazurIl sulfon 100mg
An active metabolite of toltrazuril; formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by CYP enzymes, including CYP3A; inhibits T. gondii tachyzoite production in African green monkey kidney cells at 0.1, 1, and 5 UG/ml; completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis at 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection; reduces the number of infected mice in the same model at 10 mg/kg for 11 days starting six days following infection
Cayman Chemical AstragalosIde II 50mg
A triterpene saponin with diverse biological activities; increases the phosphatase activity of CD45 in cell-free assays using pNPP or OMFP as substrates (EC50s = 9.23 and 5.37 UG/ml, respectively); inhibits replication of dengue virus serotypes 1 and 3 in infected Vero cells (MIC = 1.56 UG/ml for both); increases concanavalin A-induced proliferation of primary mouse splenocytes at 30 nM; inhibits autophagy and enhances apoptosis induced by cisplatin in SGC-7901 gastric cancer cells at 50 µM; prevents decreases in small intestine and colon length, as well as body weight, in a mouse model of TNBS-induced colitis at 10 mg/kg; decreases the urinary albumin-to-creatinine ratio and improves histopathological scores in a rat model of STZ-induced diabetic nephropathy at 3.2 and 6.4 mg/kg
Cayman Chemical LauroylDLCarnItInchLRId 50mg
A zwitterionic, long-chain acylcarnitine used to improve in vivo absorption of certain hydrophilic compounds, especially through mucosal membranes
Cayman Chemical DInItolmIde 100mg
An anticoccidial agent; dietary administration reduces mortality and decreases the number of oocysts and oocyst sporulation in chick models of E. maxima, E. brunetti, or E. acervulina infection from 125-500 ppm
Cayman Chemical 4fluoroaPyrroldInopentIop 50mg
An isomer of α-PVP characterized by the addition of a fluorine group at the 4 position of the phenyl ring; intended for forensic and research applications
Cayman Chemical nastrozole 50mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical 3methoxy TyramInhydrochlo 50mg
A natural metabolite of dopamine; a weak agonist of TAAR1 (EC50 = 1.7 µM)
Cayman Chemical Bcuculn 100mg
A competitive GABAA receptor antagonist that at 100 μM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons; reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 = 1.7 μM); mimics the action of epilepsy and thus used in experimental studies as a convulsant
Cayman Chemical OseltamIvIrphosphate 100mg
An antiviral prodrug targeted against the influenza viruses; once hydrolyzed to its active metabolite, it can competitively inhibit viral neuraminidase (IC50s = 0.1-4.9 nM for influenza neuraminidases A and B)
Cayman Chemical TrIGalNAc OAc3trIfluoROC 100mg
An intermediate in the synthesis of LYTACs with anticancer activity
Cayman Chemical FluphenazIn decnoate 100mg
A prodrug form of fluphenazine; induces random mouth movements in rats; increases serum levels of prolactin and decreases LH and FSH, as well as decreases desire to mate and litter size, in male rats at 3 mg/kg per day; It increases lethargy and passive contact and reduces self-grooming, social grooming, auditory startle response, and propensity to attack other animals in monkeys
Sigma Aldrich Fine Chemicals Biosciences Human serum serum proteins
ERM-DA470k/IfCC replaces the former product ERM-DA470. The new reference material is certified for 12 serum proteins. The material is the lyophilised form of processed serum and is certified for A2M AAG AAT ALB C3C C4 HPT IgA IgG IgM TRf and TTR.
Cayman Chemical SertaconazolenItrate 50mg
An imidazole antifungal agent; active against various yeasts, including C. albicans and C. tropicalis, and dermatophytes, including Microsporum, Trichophyton, and Epidermophyton (MICs = 0.35-5.04 and 0.24-2 UG/ml, respectively); inhibits ergosterol biosynthesis (IC50 = 115 nM) and decreases intracellular ATP levels in C. albicans; topical application reduces EAr edema induced by TPA, resiniferatoxin, or oxazolone in mouse models of irritant dermatitis, neurogenic dermatitis, and allergic contact hypersensitivity, respectively; selectively inhibits ACSL4 (IC50 = 0.28 µM) over ACSL3 at 50 µM; inhibits lipid peroxidation and ferroptosis induced by (1S,3R)-RSL3 in LUHMES cells at 5 µM