Human Sera
Cayman Chemical GaboxadolhydrochlorIde 50mg
A GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)); acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).
Cayman Chemical TetrabenazIn 100mg
An inhibitor of VMAT2 that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay); dose-dependently reduces levels of the monoamines norepinephrine, dopamine, and 5-HT in rat brain; has been used to induce depressive-like behavior in animal models; improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal MSNs in a YAC128 transgenic mouse model of Huntington’s disease at 5 mg/kg
Cayman Chemical PIcrocrocIn 100mg
A monoterpene glycoside with anticancer activity; a biosynthetic precursor of safranal; inhibits the growth of HeLa cells (IC50 = 3 mM)
Cayman Chemical FlupIrtInmaleate 50mg
An activator of Kv7/KCNQ; induces relaxation of preconstricted pulmonary arteries isolated from wild type and SERT+ mice; decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension at 30 mg/kg per day; increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg; increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine; indirectly antagonizes NMDA receptors via its effects on potassium channels
Cayman Chemical Ciclesonide 50MG
A prodrug form of desisobutyryl-ciclesonide; binds to the glucocorticoid receptor (Ki = 37 nM); selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors; inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation
Cayman Chemical LInoleoyl EthnolamIde 50mg
An endocannabinoid that contains linoleate in place of the arachidonate moiety of AEA; has been detected in porcine brain and murine peritoneal macrophages and has weak affinity for the CB1 and CB2 receptors (Kis =10 µM and 25 µM, respectively); 4-fold less potent than AEA at causing catalepsy in mice (ED50 = 26.5 mg/kg); increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner; inhibits human FAAH-dependent hydrolysis of AEA (Ki = 9.0 µM), but is also effectively hydrolyzed by the enzyme
Cayman Chemical 2 3MehylendIoxy PyrovalRo 50mg
A potential psychoactive designer drug structurally related to 3,4-MDPV; intended for forensic purposes
Cayman Chemical LInoelaIdIc AcId 100mg
Linoelaidic acid is the all-trans fatty acid homolog of linoleic acid. Trans-fatty acids are generally not detected in raw food oils, but constitute up to 25% of the unsaturated fat in partially hydrogenated oils.{5470}
Cayman Chemical NundecnoylLHomoserIn lac 50mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM; inhibits concanavalin A-induced proliferation of isolated mouse splenocytes (IC50 = 90 µM)
Cayman Chemical TrIamcInolon acetonIde 100mg
A synthetic corticosteroid; decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model at 1.5 mg/kg administered prior to and following surgery for three days; decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally
Cayman Chemical 5Cyno2 3dI ptolyltetra 100mg
A redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms; readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal (absorption maximum at 450 nm)
Cayman Chemical NIcergolIn 100mg
An α1-AR antagonist; binds to α1-ARs in rat brain membranes (Ki = 12.5 nM); inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively); inhibits cirazoline-induced pressor responses in rats at 0.5 UG/kg per minute, i.v.; improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg; increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
Cayman Chemical PF-04418948 50mg
An orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM); over 1,000-fold less active at other prostanoid receptors, including other EP receptors
Cayman Chemical IsoprInosIn 50mg
A complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio; has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production; shows antiviral activity
Cayman Chemical 5-trns Latnoprost 50mg
A derivative of latanoprost (free acid), an isomer of latanoprost, and an analytical standard; may have similar biological activities as F-type prostaglandin cis isomers; a potential impurity in commercial preparations of latanoprost; intended as an analytical standard