Goat Secondary Antibodies
Cayman Chemical PACAP6-38humnchIcken500ug
A PACAP receptor antagonist (IC50s = 30, 600, and 40 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors ); binds to PACAP receptors in rat brain membrane (IC50 = 39.14 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 2.9, 129, and 227 nM, respectively); inhibits vasodilation of pial arterioles induced by PACAP-38 in newborn pigs (10 μM); blocks CARTp-induced decreases in food intake and reduction in body weight in rats (0.3-3 mol per animal, i.c.v.)
Cayman Chemical 5Z8ZTetradecadIenoIcAc50ug
An internal standard for the quantification of 5(Z),8(Z)-tetradecadienoic acid by GC- or LC-MS
Cayman Chemical Sinapic Acid, Purity: ≥98%, CAS: 530-59-6, 5 g
A phenylpropanoid hydroxycinnamic acid with diverse biological activities; inhibits collagen-induced human platelet aggregation (IC50 = 1.03 mM); scavenges DPPH and ABTS free radicals (IC50s = 8.3 and 5.4 μg/ml, respectively); reduces colony formation of SW480 human colon carcinoma cells by 4-fold at 200 μM; inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively); increases the time spent in the open arms of the elevated plus maze in mice at 4 mg/kg; commonly used as a matrix in protein mass spectrometry
Cayman Chemical Perfluorobutylsulfonamide, Purity: ≥95%, CAS: 30334-69-1, 500 mg
A perfluoroalkyl substance; has been found as a contaminant in wastewater and consumable Tampa Bay oysters
Cayman Chemical InfluenzaAH1N1SwInFlu220uL
An active metabolite of thalidomide and a PROTAC synthetic intermediate decreases production of TNF-a induced by TPA in THP-1 cells at 30 UM completely inhibits the proliferation HUVECs at 333 UM inhibits VEGF- and FGF2-induced angiogenesis by 14 in a CAM assay in utero at 100 Ug/embryo
Cayman Chemical Dapansutrile, Purity: ≥98%, CAS: 54863-37-5, 250 mg
An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 μM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS
Cayman Chemical Sinigrin (hydrate), Purity: ≥95%, 500 mg
A glucosinolate; inhibits NLRP3 inflammasome activation in ATP-stimulated, LPS-primed RAW 264.7 cells in a concentration-dependent manner; reduces LPS-induced NO and PGE2 production, as well as NF-κB activation, in RAW 264.7 cells; induces cell cycle arrest at the G0/G1 phase in HepG2 hepatocellular carcinoma cells at 0.1 and 0.5 mM; increases in renal glomerular basement membrane thickness, as well as increases in systolic and diastolic blood pressure, in a rat model of angiotensin II-induced hypertension
Cayman Chemical Betamethasone Dipropionate, Purity: ≥98%, CAS: 5593-20-4, 250 mg
A synthetic corticosteroid and prodrug from of betamethasone; binds to the glucocorticoid receptor (IC50 = 5.25 nM); decreases the number of circulating eosinophils in dogs; reduces croton oil-induced exudate formation in a granuloma pouch assay in rats
Cayman Chemical Choline (chloride), Purity: ≥95%, CAS: 67-48-1, 50 g
An essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis; a precursor in the biosynthesis of membrane phospholipids and to the neurotransmitter acetylcholine; is required for hepatic lipid transport; perinatal administration improves prenatal alcohol exposure-induced cognitive deficits in rats at 18.8 mg/kg; improves motor coordination and behavioral deficits in a mouse model of Rett syndrome at 13 mg/animal per day; improves deficits in recognition memory induced by early-life iron deficiency in rats at 5 ppm in the drinking water; deficiences are positively correlated with muscle wasting; dietary administration increases leg and breast muscle protein content in broiler chickens
Cayman Chemical 5,7-Dimethoxyflavone, Purity: ≥98%, CAS: 21392-57-4, 250 mg
A flavonoid with diverse biological activities; induces the production of ROS, cell cycle arrest at the G1 phase, and apoptosis in HepG2 cells at 10, 25, and 50 µM; reduces exudate volume and inhibits prostaglandin production in a rat model of carrageenan-induced pleurisy from 75-150 mg/kg; reduces rectal temperature in a rat model of yeast-induced hyperthermia; reduces serum triglyceride, total cholesterol, and LDL levels, as well as increases serum insulin levels and reduces blood glucose levels in a rat model of STZ-induced diabetes
Cayman Chemical A2764 (hydrochloride), Purity: ≥98%, CAS: 861038-72-4, 250 mg
An inhibitor of K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor); selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM; inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons at 100 µM
Cayman Chemical 2H,2H,3H,3H-Perfluorohexanoic Acid, Purity: ≥95%, CAS: 356-02-5, 500 mg
A polyfluoroalkyl substance; has been found as a contaminant in sea and river water
Cayman Chemical Sodium Lauryl Sulfoacetate, Purity: ≥95%, CAS: 1847-58-1, 250 mg
An anionic surfactant; increases proliferation of isolated chicken PBMCs at 62.5-500 µg/ml; increases the blood CD4+ to CD8+ T cell ratio induced by a Newcastle disease virus vaccine in chickens at 1,2, and 4 mg/kg
Cayman Chemical Deoxycorticosterone Acetate, Purity: ≥95%, CAS: 56-47-3, 10 g
A corticosteroid; has commonly been used in rodents as a model of salt-sensitive hypertension, characterized by increases in sympathetic nervous system activity, imbalances in the renin-angiotensin system (RAS), and cardiac remodeling in combination with saline
Cayman Chemical 1,3-Benzodioxole-5,6-diamine (hydrochloride), Purity: ≥98%, CAS: 81864-15-5, 50 mg
A fluorescent derivatization reagent; has been commonly used for the derivatization of α-keto, neuraminic, and sialic acids for detection by fluorometric HPLC