Rabbit Secondary Antibodies
ABclonal Technology PAH Rabbit mAb
This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase protein family The encoded phenylalanine hydroxylase enzyme hydroxylates phenylalanine to tyrosine and is the rate-limiting step in phenylalanine catabolism Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria
ABclonal Technology ABflo 610 Rabbit anti- CD48
Predicted to enable antigen binding activity and signaling receptor activity Acts upstream of or within T cell activation and signal transduction Located in external side of plasma membrane Is expressed in left lung liver right lung and thymus primordium Orthologous to human CD48 (CD48 molecule)
Cayman Chemical LAMP1CD107a RabbIt MoncLN 50uL
An inhibitor of quorum sensing inhibits activation of the quorum-sensing regulator LuxR in aBgalactosidase reporter assay at 25 UM
ABclonal Technology CYP11A1 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone the first and rate-limiting step in the synthesis of the steroid hormones Two transcript variants encoding different isoforms have been found for this gene The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide
ABclonal Technology MAVS Rabbit mAb
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity
Cayman Chemical PTENCTerm RabbIt Monclon 100uL
A selective estrogen receptor covalent antagonist covalently modifies cysteine 530 in the ligand binding domain of wild-type ERa and ERaY537S inhibits expression of the ERa target genes GREB1 and TFF1 in MCF-7 cells overexpressing wild-type ERa (IC50s 2.74 and 1.3 nM respectively) ERaY537S (IC50s 29.38 and 19.4 nM respectively) ERaY537N (IC50s 8.14 and 6.1 nM respectively) ERaY537C (IC50s 12.19 and 9.5 nM respectively) or ERaD538G (IC50s 24.87 and 4 nM respectively) inhibits the growth of MCF-7 cells overexpressing wild-type ERa or ERaY537S (GI50s 1.3 and 8.3 nM respectively) reduces tumor growth in an MCF-7 mouse xenograft model and an ERaY537S/WT ST941 PDX mouse model in a dose-dependent manner
Cell Signaling Technology Ron C81H9 Rabbit mAb BSA and Azide Free 100 ug
Ron C81H9 Rabbit mAb BSA and Azide Free 100 ug
Cayman Chemical EGFRL858R RabbIt MoncLNal A
A dual agonist of FXR and PPAR activates FXR and PPAR in reporter assays using HEK293T cells (EC50s 0.94 and 1.5 UM respectively) selective for these receptors over RARa RXRa PPARa PPARY and LXRa at 10 UM
ABclonal Technology TCAP Rabbit mAb
Sarcomere assembly is regulated by the muscle protein titin Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere It serves as a scaffold to which myofibrils and other muscle related proteins are attached This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase interactions thought to be critical to sarcomere assembly Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G
Cayman Chemical SATB2CTerm RabbIt Monclo 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models
ABclonal Technology 647 Rabbit anti- CD272/BTLA
Enables signaling receptor activity Acts upstream of or within immune response-regulating cell surface receptor signaling pathway negative regulation of B cell proliferation and negative regulation of alpha-beta T cell proliferation Located in external side of plasma membrane Is integral component of plasma membrane Orthologous to human BTLA (B and T lymphocyte associated)
ABclonal Technology CYP3A4 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents This enzyme is involved in the metabolism of approximately half the drugs in use today including acetaminophen codeine cyclosporin A diazepam erythromycin and chloroquine The enzyme also metabolizes some steroids and carcinogens This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21 1 Previously another CYP3A gene CYP3A3 was thought to exist however it is now thought that this sequence represents a transcript variant of CYP3A4 Alternatively spliced transcript variants encoding different isoforms have been identified
Cayman Chemical FcεRIICD23CTerm RabbIt M 100uL
A mutagenic heterocyclic amine mutagenic to S. typhimurium in the Ames test induces tumor formation in the Zymbal gland oral cavity and colon in male and female rats the skin of male rats and the mammary gland in female rats at 0.03 in the diet