Rabbit Secondary Antibodies
ABclonal Technology NFYA Rabbit mAb
The protein encoded by this gene is one subunit of a trimeric complex forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes Subunit A associates with a tight dimer composed of the B and C subunits resulting in a trimer that binds to DNA with high specificity and affinity The sequence specific interactions of the complex are made by the A subunit suggesting a role as the regulatory subunit In addition there is evidence of post-transcriptional regulation in this gene product either by protein degradation or control of translation Further regulation is represented by alternative splicing in the glutamine-rich activation domain with clear tissue-specific preferences for the two isoforms
Cayman Chemical PLAPNTerm RabbIt Monclon 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
Cayman Chemical CD79aCTerm RabbIt Monclo 100uL
A BET family protein inhibitor inhibits binding of BRD2 BRD3 and BRD4 to an acetylated histone H4 peptide in vitro decreases Myc levels in and inhibits proliferation of AML DLBCL and MM cells reduces tumor growth in AML DLBCL and MM mouse xenograft models reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
ABclonal Technology CD307b Rabbit mAb
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
ABclonal Technology WFS1 Rabbit mAb
This gene encodes a transmembrane protein which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain pancreas heart and insulinoma beta-cell lines Mutations in this gene are associated with Wolfram syndrome also called DIDMOAD (Diabetes Insipidus Diabetes Mellitus Optic Atrophy and Deafness) an autosomal recessive disorder The disease affects the brain and central nervous system Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6) also known as DFNA14 or DFNA38 Alternatively spliced transcript variants have been found for this gene
Cayman Chemical EPCRCD201 RabbIt MoncLNal 50uL
An inhibitor of RNA polymerase I-mediated transcription binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells at 10 UM induces apoptosis in A549 and HL-60 cells at 5 UM reduces tumor growth in MDA-MB-231 and MiaPaCa-2 mouse xenograft models at 5 mg/kg
ABclonal Technology DDX3X/DDX3Y Rabbit mAb
The protein encoded by this gene is a member of the DEAD-box RNA helicase family defined by the Asp-Glu-Ala-Asp (DEAD) motif with ATP-dependent RNA helicase and RNA-independent ATPase activities Unlike most DEAD-box helicases its ATPase activity is stimulated by both RNA and DNA It plays roles in the nucleus (transcriptional regulation mRNP assembly pre-mRNA splicing and mRNA export) and cytoplasm (translation cellular signaling and viral replication) Misregulation is linked to tumorigenesis This gene has a paralog on the Y chromosome and pseudogenes on chromosomes 4 and X Mutations can cause male infertility reduced germ cell numbers and Sertoli-cell only syndrome Alternative splicing generates multiple isoforms
American Research Products Inc Rabbit matriX metalloproteinas
Rabbit matriX metalloproteinase 1 MMP-1 ELISA kit from CUSABIO Detection Range 0 156 ng/mL-10 ng/mL Sensitivity 0 039 ng/mL Sample serum plasma tissue homogenates Method Sandwich
Cayman Chemical mP-12C-Term RabbIt Moncl 100uL
A CaMKK inhibitor (IC50s 120 and 40 ng/ml for CaMKKa and CaMKKB respectively) selective for CaMKKs over CaMKI CaMKII CaMKIV MLCK PKC PKA and p42 MAPK (IC50s ≥ 10000 ng/ml for all) inhibits phosphorylation of CaMKI and AMPK in chicken sperm in the presence of extracellular calcium as well as reduces chicken sperm motility decreases Npy and Agrp expression and cumulative food intake in mice at 20 M 0.5 L/hour i.c.v. increases cortical striatal and total infarct volume in a mouse model of MCAO-induced focal transient cerebral ischemia at 3 g/animal i.c.v.
Cayman Chemical FcRICD64 RabbIt Monclonal 50uL
A metabolite of bortezomib a degradation product of bortezomib formed under oxidative conditions
Cayman Chemical p53NTerm RabbIt Monclona 100uL
A polyketide active against S. aureus and E. coli in agar diffusion assays at 64 Ug/disc inhibits growth of HM02 KATO III HepG2 and MCF-7 cancer cells (GI50s 0.1 0.7 0.1 and 7.5 Umol/L)
Cayman Chemical aActInIn4NTRm RabbIt M 100uL
An internal standard for the quantification of PGB2 by GC- or LC-MS.
Cayman Chemical Surfactnt ProteIn B RabbIt M
An internal standard for the quantification of tasimelteon by GC- or LC-MS
Cayman Chemical AMACRNTerm RabbIt Monclo 100uL
A heterocyclic building block has been used in the synthesis of prolyl-tRNA synthase inhibitors