Rabbit Secondary Antibodies
Cayman Chemical BOB1OBF1CTerm RabbIt M 100uL
A GRK inhibitor (IC50s 3.9 0.15 and 0.38 M for GRK1 GRK2 and GRK5 respectively) selective for GRKs over PKA (IC50 120 M) increases contractility in isoproterenol-stimulated isolated mouse cardiomyocytes at 500 nM prevents the desensitization of histamine H1 receptor- and purinergic P2Y2 receptor-driven phospholipase C signaling in human ULTR myometrial cells and isolated rat MSMCs respectively (IC50s 3.09 and 2.95 M respectively)
ABclonal Technology ATP6 Rabbit mAb
Predicted to contribute to proton-transporting ATP synthase activity rotational mechanism Predicted to be involved in mitochondrial ATP synthesis coupled proton transport Located in mitochondrion Is expressed in several structures including alimentary system brain heart integumental system and sensory organ Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy NARP syndrome Parkinson s disease multiple sclerosis and systemic lupus erythematosus Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6)
ABclonal Technology ATP6AP1 Rabbit mAb
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting zymogen activation and receptor-mediated endocytosis The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules This protein may also play a role in early development
Cayman Chemical FcRICD64 RabbIt MoncLNal 100uL
A fatty ester and isomer of linoleic acid ethyl ester
ABclonal Technology APC Rabbit anti-Mouse CD47 mAb
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion and thrombospondin receptor activity Involved in regulation of nitric oxide biosynthetic process Acts upstream of or within several processes including monocyte aggregation opsonization and positive regulation of phagocytosis Located in extracellular exosome Is integral component of plasma membrane Is expressed in several structures including alimentary system central nervous system genitourinary system hemolymphoid system gland and liver and biliary system Orthologous to human CD47 (CD47 molecule)
Cayman Chemical PSD95NTerm RabbIt Moncl 100uL
An isomer of vitamin D3 increases tibia ash weight and bone mineralization in vitamin D-deficient chicks at 1 3 and 10 Ug/day induces intestinal calcium transport and bone calcium mobilization in anephric rats fed a low-calcium and vitamin D-deficient diet at 25 Ug/animal
ABclonal Technology TAP2 Rabbit mAb
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR TAP MRP ALD OABP GCN20 White) This protein is a member of the MDR TAP subfamily Members of the MDR TAP subfamily are involved in multidrug resistance This gene is located 7 kb telomeric to gene family member ABCB2 The protein encoded by this gene is involved in antigen presentation This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum Mutations in this gene may be associated with ankylosing spondylitis insulin-dependent diabetes mellitus and celiac disease Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules
Cayman Chemical CD3εCTerm RabbIt Monclon 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models
ABclonal Technology PSMC5 Rabbit mAb
The 26S proteasome is a multicatalytic complex composed of a 20S core and a 19S regulator The 20S core has four rings of 28 subunits (two rings of 7 alpha and two of 7 beta subunits) The 19S regulator includes a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits) Proteasomes abundant in eukaryotic cells degrade peptides in an ATP- and ubiquitin-dependent manner outside of lysosomes The immunoproteasome variant processes MHC class I peptides This gene encodes one of the ATPase subunits part of the AAA family of ATPases with chaperone-like activity Beyond proteasome function this subunit may regulate transcription by interacting with thyroid hormone and retinoid X receptors Two transcript variants encoding different isoforms exist
ABclonal Technology AUH Rabbit mAb
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA a critical step in the leucine degradation pathway This protein also binds AU-rich elements (AREs) found in the 3 UTRs of rapidly decaying mRNAs including c-fos c-myc and granulocyte macrophage colony stimulating factor ARE elements are involved in directing RNA to rapid degradation and deadenylation This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis Mutations in this gene are the cause of 3-methylglutaconic aciduria type I Alternative splicing results in multiple transcript variants