Rabbit Secondary Antibodies
ABclonal Technology ALK Rabbit mAb
This gene encodes a receptor tyrosine kinase which belongs to the insulin receptor superfamily This protein comprises an extracellular domain an hydrophobic stretch corresponding to a single pass transmembrane region and an intracellular kinase domain It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system This gene has been found to be rearranged mutated or amplified in a series of tumours including anaplastic large cell lymphomas neuroblastoma and non-small cell lung cancer The chromosomal rearrangements are the most common genetic alterations in this gene which result in creation of multiple fusion genes in tumourigenesis including ALK (chromosome 2) EML4 (chromosome 2) ALK RANBP2 (chromosome 2) ALK ATIC (chromosome 2) ALK TFG (chromosome 3) ALK NPM1 (chromosome 5) ALK SQSTM1 (chromosome 5) ALK KIF5B (chromosome 10) ALK CLTC (chromosome 17) ALK TPM4 (chromosome 19) and ALK MSN (chromosome X)
Jackson Immuno Research Labs AffiniPure Rabbit Anti-Horse IgG (H+L)
AffiniPure Rabbit Anti-Horse IgG (H+L)
FUJIFILM BIOSCIENCES INC Anti SQSTM1/A170/p62 Rabbit 10
Sequestosome 1 SQSTM1 /A170 mouse /p62 human /ZIP rat a ubiquitin-binding protein expresses oxidative stress-dependently Abnormality of SQSTM1 leads to bone metabolic disorder obesity and Type II diabetes SQSTM1 was reported to bind LC3 which regulates autophagosome formation The protein has attracted the attention of researchers because it is believed to induce a protein from ubiquitin-proteosome system UPS to the lysosome-dependent macroautophagy autophagy system which are two major intracellular pathways for protein degradation This antibody is useful for immunofluorescence immunohistochemistry and Western blotting
Cayman Chemical CD33CTerm RabbIt Monclon 100uL
A pyrimidine analog and nitrosourea alkylating agent inhibits the growth of U-251MG and EA285 glioma cells at 10 g/ml increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors at 30 mg/kg
Cayman Chemical PSMACTerm RabbIt Monclon 100uL
A RIPK2 inhibitor inhibits RIPK2 by 65 in a kinase assay at 10 UM inhibits VEGFR3 by greater than 90 as well as 14 additional kinases by 60-89 in a panel of 344 kinases at 10 UM reduces colonic damage in a mouse model of TNBS-induced colitis at 7.5 and 145 mg/kg twice per day a prodrug
ABclonal Technology JAM-A/CD321/F11R Rabbit
Predicted to enable PDZ domain binding activity integrin binding activity and protein homodimerization activity Involved in intestinal absorption regulation of cytokine production and regulation of membrane permeability Acts upstream of or within cell adhesion and epithelial cell differentiation Located in bicellular tight junction Is expressed in several structures including 4-8 cell stage embryo alimentary system respiratory system sensory organ and urinary system Human ortholog(s) of this gene implicated in hypertension Orthologous to human F11R (F11 receptor)
Cayman Chemical InTRleukIn6 RabbIt MoncLN 50uL
A p70S6K1 inhibitor (IC50 52 nM) selective for p70S6K1 over a panel of 43 kinases at 1 UM
Cayman Chemical B7H3CD276CTerm RabbIt M 100uL
A quaternary ammonium-containing cationic surfactant with diverse biological activities an inhibitor of F. tularensis AcpB (Ki 0.59 UM) and C. albicans V-ATPase (EC50 69 UM) inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs inhibits bone resorption by mature osteoclasts at 100 and 200 nM prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day induces mortality in C. oncophora O. ostertagi H. contortus and T. circumcincta (EC50s 4.5 10.8 5.1 and 6.7 UM respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s 9.2 and 5.7 UM respectively)
Cayman Chemical NF-KBp105p50 RabbIt Monc 100uL
A BMI1 inhibitor inhibits proliferation of OVCAR-4 and OV-90 cells (IC50s 0 1 UM for both) induces BMI1 degradation in and apoptosis of the same cells reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MDS-L cells at 3 and 0 03 UM respectively reduces tumor growth in a OV-90 orthotopic mouse model of ovarian cancer at 15 mg/kg biweekly
ABclonal Technology UGT1A1 Rabbit mAb
This gene encodes a UDP-glucuronosyltransferase an enzyme of the glucuronidation pathway that transforms small lipophilic molecules such as steroids bilirubin hormones and drugs into water-soluble excretable metabolites This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases The locus includes thirteen unique alternate first exons followed by four common exons Four of the alternate first exons are considered pseudogenes Each of the remaining nine 5 exons may be spliced to the four common exons resulting in nine proteins with different N-termini and identical C-termini Each first exon encodes the substrate binding site and is regulated by its own promoter The preferred substrate of this enzyme is bilirubin although it also has moderate activity with simple phenols flavones and C18 steroids Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome
ABclonal Technology SMG1 Rabbit mAb
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein Alternatively spliced transcript variants have been described but their full-length nature has yet to be determined
Cayman Chemical CD4NTerm RabbIt Monclona 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models
ABclonal Technology Pepsinogen II PG II Rabbit mAb
This gene encodes an aspartic proteinase that belongs to the peptidase family A1 The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa This protein is also secreted into the serum This protein is synthesized as an inactive zymogen that includes a highly basic prosegment This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself Polymorphisms in this gene are associated with susceptibility to gastric cancers Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis Alternate splicing results in multiple transcript variants A pseudogene of this gene is found on chromosome 1
Immunology Consultants anti-Mouse IgG h+l Antibody (Rabbit) - Affinity Purified
RGHL‑90A is an affinity‑purified rabbit antibody specific for mouse IgG heavy and light chains, designed for use as a secondary antibody in immunoassays. This reagent provides strong, selective binding and low background, supporting reliable detection in ELISA, Western blotting, and other immunochemical applications. Produced by Immunology Consultants and supplied in a 1 mg format, RGHL‑90A is an essential tool for researchers working with murine antibodies.