Signal Transduction Reagents and Kits
Revvity Health Sciences Inc HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.
Echelon Biosciences Research Labs PI(3)P DIC8 AMMONIUM SALT 1 mg
PI(3)P diC8 (Phosphatidylinositol 3-phosphate diC8) is a synthetic, purified dioctanoyl PI(3)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Echelon Biosciences Research Labs Ins(1,3,4)P3 500 ug
Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,3,4-trisphosphate (Ins(1,3,4)P3) is an intermediate in the inositol phosphate pathway. Ins(1,3,4)P3 inhibits Ins(3,4,5,6)P4 1-kinase which regulates Ins(3,4,5,6)P4 levels. Ins(3,4,5,6)P4 in turn is responsible for inhibiting calcium-activated chloride channels. Ins(1,3,4)P3 is produced by dephosphorylation of Ins(1,3,4,5)P4 by a 5-phosphatase. Ins(1,3,4)P3 is a substrate for phosphatases yielding Ins(1,3)P2 and Ins(3,4)P2. This item is non returnable
Axxora LLC 6-Bn-ATP-γ-S | 944834-42-8 | 5umol
6-Bn-ATP-γ-S | Purity: 95% | Mol Wt: 613.4 | 944834-42-8 | 5umol
Enzo Life Sciences Folic acid (10g). CAS: 59-30-3
Alternative name: Pteroylglutamic acid. Purity: ≥97% (HPLC). Solubility: Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol; almost insoluble in organic solvents. Long Term Storage: +4°C.
Axxora LLC c-diGMP | 61093-23-0 | MFCD31563661 | 1 umol
c-diGMP | Purity: 98% | Mol Wt: 690.4 | 61093-23-0 | MFCD31563661 | 1 umol
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 5 MG
Reticuline demonstrates anti-inflammatory effects by influencing the JAK2/STAT3 and NF-κB signaling pathways. It decreases the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Additionally, Reticuline exhibits cardiovascular effects.
- Inhibits mRNA expressions of TNF-α and IL-6.
- Reduces phosphorylation levels of JAK2 and STAT3.
- Exhibits cardiovascular effects.
- Purity: 98.89%.
- Appearance: Solid, white to yellow.
- For research use only.
Echelon Biosciences Research Labs SHUTTLE PIP KIT PI(5)P
Echelon Biosciences - Shuttle PIP Kit - P-9005 - PI(5)P This item is non returnable
Montana Molecular Green Ratiometric Cilia-Targeted cADDis cAMP Sensor Kit D0211G, 10mL, CMV
Measure real-time cAMP signaling kinetics in the primary cilia with this live cell fluorescent assay. Add cADDis to your cells and measure robust signals the next day on a fluorescence imaging system. Decreasing green fluorescence indicates ciliary cAMP increase. Constitutively expressed cytosolic red fluorescence can be used for ratiometric measurements. This assay is genetically encoded and packaged in BacMam for efficient delivery to cilia in most cell types, including many primary and iPSC-derived cells.
Apexbio Technology LLC Aurora Kinase Inhibitor III 879127-16-9 1mg
Aurora Kinase Inhibitor III (CAS 879127-16-9) is a selective small molecule inhibitor targeting Aurora A kinase It acts by binding to the ATP-binding site of Aurora A thereby suppressing its enzymatic activity with an IC50 of 42 nM The compound exhibits substantially lower inhibitory potency against epidermal growth factor receptor (EGFR) with an IC50 greater than 10 M Aurora Kinase Inhibitor III serves as a useful chemical probe for investigating Aurora A-mediated processes including mitotic regulation cell cycle progression and associated signaling pathways and supports studies exploring the role of Aurora A in oncogenesis
Selleck Chemical LLC Zolmitriptan 10mg 139264-17-8
Zolmitriptan is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs Chymotrypsin like enzyme substrate - 5 mg,
Chymotrypsin like enzyme substrate - 5mg , Succinyl-Leu-Leu-Val-Tyr-AFC Category/Application: Enzyme Substrates This item is non returnable
Waters Corporation Upgrade Kit, Transducer BGM, for HPLC Systems
This upgrade kit is designed to update early 2545 Binary Gradient Modules in HPLC systems. It provides a newer style pressure transducer with a die-cast housing, along with tubing assemblies and an adapter, to replace older, round version transducers.
- Provides one pressure transducer and tubing assemblies.
- Updates early 2545 Binary Gradient Modules.
- Features a newer style transducer with a die-cast housing.
- Replaces older, round version transducers.
- Includes an adapter for installation to the pump head.
- Suitable for HPLC systems.
- Units per package: 1.