Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs Chymotrypsin like enzyme substrate - 5 mg,
Chymotrypsin like enzyme substrate - 5mg , Succinyl-Leu-Leu-Val-Tyr-AFC Category/Application: Enzyme Substrates This item is non returnable
Cell Signaling Technology SignalSlide Phospho-Met (Tyr1234/1235) IHC Controls 1 Pack
SignalSlide Phospho-Met (Tyr1234/1235) IHC Controls 1 Pack
Aat Bioquest CALBRYTE-520 ASSAY KIT 1 PLATE
Calbryte-520 Probenecid-Free and Wash-Free Calcium Assay Kit 1 plate
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.
Sigma Aldrich Fine Chemicals Biosciences Calpeptin >=98% (HPLC) | 117591-20-5 | MFCD00155623 | 5MG
Calpeptin >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 362.46 | 117591-20-5 | MFCD00155623 | 5MG
Medchemexpress LLC Uk122 | 940290-58-4 | 99.9% | 291.30 g/mol | C17H13N3O2 | 5 MG
A selective small-molecule inhibitor of urokinase-type plasminogen activator (uPA) for biochemical and cellular research into protease-mediated processes such as cancer cell migration and invasion. It is a 4-oxazolidinone analogue with reported uPA inhibition (IC50 0.2 μM). Supplied as a research reagent, not for human or veterinary use.
- Selective uPA inhibition with IC50 of 0.2 μM.
- 4-oxazolidinone analogue suitable for mechanistic studies.
- High purity (~99.9%) for reproducible biochemical assays.
- Small-molecule format compatible with cell-based and enzymatic assays.
- Available in small research quantities for laboratory use.
Enzo Life Sciences Folic acid (10g). CAS: 59-30-3
Alternative name: Pteroylglutamic acid. Purity: ≥97% (HPLC). Solubility: Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol; almost insoluble in organic solvents. Long Term Storage: +4°C.
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Enzo Life Sciences Salubrinal (5mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Appearance: White to off-white powder. Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Creative Biomart Galsulfase, Human N-acetylgalactosamine 4-sulfatase
The product is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. The product is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 5 MG
Reticuline demonstrates anti-inflammatory effects by influencing the JAK2/STAT3 and NF-κB signaling pathways. It decreases the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Additionally, Reticuline exhibits cardiovascular effects.
- Inhibits mRNA expressions of TNF-α and IL-6.
- Reduces phosphorylation levels of JAK2 and STAT3.
- Exhibits cardiovascular effects.
- Purity: 98.89%.
- Appearance: Solid, white to yellow.
- For research use only.
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 1 MG
Reticuline exhibits anti-inflammatory effects by influencing JAK2/STAT3 and NF-κB signaling pathways. It inhibits the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline also demonstrates cardiovascular effects.
- Inhibits JAK2/STAT3 and NF-κB signaling pathways.
- Reduces TNF-α and IL-6 mRNA expression.
- Decreases JAK2 and STAT3 phosphorylation.
- Shows cardiovascular effects.
- Purity of 98.89%.
- Appearance: white to yellow solid.
- Soluble in DMSO.
Apexbio Technology LLC Aurora Kinase Inhibitor III 879127-16-9 1mg
Aurora Kinase Inhibitor III (CAS 879127-16-9) is a selective small molecule inhibitor targeting Aurora A kinase It acts by binding to the ATP-binding site of Aurora A thereby suppressing its enzymatic activity with an IC50 of 42 nM The compound exhibits substantially lower inhibitory potency against epidermal growth factor receptor (EGFR) with an IC50 greater than 10 M Aurora Kinase Inhibitor III serves as a useful chemical probe for investigating Aurora A-mediated processes including mitotic regulation cell cycle progression and associated signaling pathways and supports studies exploring the role of Aurora A in oncogenesis