Signal Transduction Reagents and Kits
Medchemexpress LLC HY-112815 5mg Medchemexpress, ALK2-IN-2 CAS:2254409-25-9 Purity:>98%
Medchemexpress, HY-112815 5mg ALK2-IN-2 CAS:2254409-25-9 ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 1 MG
Reticuline exhibits anti-inflammatory effects by influencing JAK2/STAT3 and NF-κB signaling pathways. It inhibits the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline also demonstrates cardiovascular effects.
- Inhibits JAK2/STAT3 and NF-κB signaling pathways.
- Reduces TNF-α and IL-6 mRNA expression.
- Decreases JAK2 and STAT3 phosphorylation.
- Shows cardiovascular effects.
- Purity of 98.89%.
- Appearance: white to yellow solid.
- Soluble in DMSO.
Enzo Life Sciences Diprotin A (25 mg) CAS: 90614-48-5
DPP4 inhibitor. Inhibitor of dipeptidyl aminopeptidase IV. Alternative Name: H-Ile-Pro-Ile-OH. Formula: C17H31N3O4. MW: 341.5. CAS: 90614-48-5. Purity: ≥98% (HPLC). Appearance: White to off-white solid. Solubility: Soluble in water (1mg/ml). Long Term Storage: -20°C
Revvity Health Sciences Inc HTRF Human IL-17A / IL17RA Binding Kit Standard
HTRF Human IL-17A / IL17RA Binding Kit Standard
Abcam Ascorbic Acid Assay Kit (Biological Samples)
Ascorbic Acid Assay Kit (Biological Samples)
The product is subject to the following: Abcam Restricted Use Statement
Echelon Biosciences Research Labs PI(4)P DIC8 AMMONIUM 100 ug
Phosphatidylinositol 4-phosphate diC8 (PI(4)P diC8) is a synthetic, purified dioctanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
Echelon Biosciences Research Labs PI(5)P DIC8 AMMONIUM SALT 500 ug
Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases. This item is non returnable
Medchemexpress LLC Tulobuterol (C-78 free base) | 41570-61-0 | 99.7% | 50 MG
Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. It is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.
- Decreases RV14 RNA levels at 1 day and 3 days after infection in human tracheal epithelial cells.
- Significantly lowers sICAM-1 concentrations in cell supernatants.
- Reduces the number and fluorescence intensity of acidic endosomes.
- Decreases RV14 infection-induced secretion of IL-1β, IL-6, and IL-8.
- Produces a small but significant reduction in p50, p65, and c-Rel of NF-κB induced by RV14 infection.
- Maintains diaphragm muscle contractility for over 24 hours in a mouse model of sepsis.
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Echelon Biosciences Research Labs 3S-PTDINS(3,4,5)P3 DIC16 500 ug
PtdIns(3,4,5)P3 3-phosphothioate, diC16 (3S-PtdIns(3,4,5)P3, diC16) is a water-soluble, synthetic PI(3,4,5)P3 analog in which the 3-phosphate has been rendered metabolically stable as a phosphorothioate. P-3S908 shows 90% inhibition of PTEN at 0.4M. This item is non returnable
Echelon Biosciences Research Labs XY-17 (LPA3 Agonist) 0.5 mg
XY-17 is a fluorinated phosphonate analog of lysophosphatidic acid (LPA). XY-17 is not hydrolyzed by lipid phosphate phosphatase (LPP) and acts as an agonist of the LPA3 receptor. This item is non returnable
Echelon Biosciences Research Labs EICOSANOYL LPA 1 mg
Arachidoyl LPA, 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA), a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Selleck Chemical LLC 6-Methylcoumarin S4802-25mg
6-Methylcoumarin (Toncarine) a synthetic fragrance widely used in cosmetics belongs to the class of organic compounds known as coumarins and derivatives
Enzo Life Sciences Salubrinal (1mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences (±)-Verapamil . hydrochloride (5g). CAS: 152-11-4
Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines. Alternative name: 5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl. Purity: ≥99% (HPLC). Appearance: White crystalline powder. Solubility: Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml). Long Term Storage: Ambient.