Enzymes and Inhibitors
![Medchemexpress LLC N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide | 1310012-12-4 | 98.1% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232177.png-250.jpg)
Medchemexpress LLC N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide | 1310012-12-4 | 98.1% | 25 MG
VU0360172 is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator supplied as a high-purity research reagent. It exhibits low-nanomolar cellular activity and contains an alkyne group for click chemistry applications.
- Potent mGlu5 positive allosteric modulator; EC50 16 nM in HEK293 cells.
- High purity (98.07%) solid, suitable for in vitro and in vivo studies.
- Soluble in DMSO (83.33 mg/mL) and formulatable for in vivo dosing (2.08 mg/mL in 10% DMSO/90% corn oil).
- Store at 4°C protected from light; in solvent store at -80°C for long-term stability.
Medchemexpress LLC Z-Leu-Leu-Glu-AMC | 348086-66-8 | MFCD01074989 | 99.5% | 664.75 | C35H44N4O9 | 25MG
Z-Leu-Leu-Glu-AMC is a fluorogenic tripeptide substrate used to measure postacidic-like (peptidylglutamyl) hydrolyzing activity of the 20S proteasome. Proteolytic cleavage releases the fluorescent 7-amino-4-methylcoumarin (AMC) reporter, enabling quantitative, sensitive measurement of proteasome activity in biochemical and enzymatic assays.
- Fluorogenic substrate for proteasome activity assays.
- Releases AMC reporter for sensitive fluorescence detection.
- Suitable for biochemical and enzymatic assay development.
- High purity for reproducible assay performance.
- Available in small research-scale quantities.
Medchemexpress LLC Tlr4-in-c34-c2-cooh | 1159408-54-4 | MFCD30802159 | 99.9% | 447.43 g/mol | C19H29NO11 | 100 MG
TLR4-IN-C34-C2-COOH is a small-molecule PROTAC linker that incorporates a TLR4 inhibitor moiety and is supplied for research use to support studies of TLR4 biology and probe or degrader synthesis. It has documented activity inhibiting TLR4 in enterocytes and macrophages and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
- High purity of 99.9%.
- Molecular formula C19H29NO11; molecular weight 447.43 g/mol.
- Soluble in DMSO and water at 100 mg/mL with ultrasonic assistance.
- Formulation examples yield ≥ 2.5 mg/mL (5.59 mM) in common in vivo vehicles.
- Available in multiple pack sizes including 100 mg.
- Intended for research use only; not for human or veterinary use.
Neogen Diagnostics K-Gold PNPP Substrate, 500 mL, Microwell, AP, Colorimetric
K-Gold Substrate is a one-bottle stabilized chromogenic substrate for use with alkaline phosphatase based immunoassays. K-Gold Substrate utilizes the substrate p-nitrophenyl-phosphate (PNPP), which reacts with alkaline phosphatase to produce the chromophore p-nitrophenol. NEOGENs ready-to-use K-Gold formula does not require mixing of additional ingredients or stabilizing agents, making it an ideal formula for kit manufacturers. Stable for a minimum of 30-months when stored at 2-8C.
CHEMPEP INC Ubiquitin-AMC, 100 μg, Fluorogenic substrate for DUB activity assays, C388H636N106O119S, Molecular Weight 8722.2 g/mol, Fluorescence Excitation 380 nm, Emission 460 nm
Ubiquitin-AMC is a highly sensitive fluorogenic substrate essential for measuring deubiquitinating enzyme (DUB) activity in biochemical assays. This versatile reagent, composed of ubiquitin conjugated to the AMC fluorophore, facilitates real-time monitoring of DUB activity by releasing a fluorescent signal. It is particularly advantageous for high-throughput screening and detailed kinetic studies in various cellular processes.
- 100 μg quantity
- Molecular formula: C388H636N106O119S
- Molecular weight: 8722.2 g/mol
- Fluorogenic substrate type
- Target enzyme class: Deubiquitinating enzymes (DUBs)
- Real-time monitoring capability
- High sensitivity for biochemical research
- Uses aqueous buffers for solubility
- Storage temperature: -20°C or below
- Avoid repeated freeze-thaw cycles
- Purity of ≥95%
- Synthetic source of ubiquitin
- Supplied as lyophilized powder or solution in DMSO
![eMolecules 115144-35-9 | D-Luciferin potassium salt | Chemodex Ltd. | MFCD00044928 | 318.410 | C11H7KN2O3S2 | 95.000 | [K+].Oc1ccc2nc(sc2c1)C1=N[C@H](CS1)C([O-])=O | 250mg | 482922421](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000130053.jpg-250.jpg)
eMolecules 115144-35-9 | D-Luciferin potassium salt | Chemodex Ltd. | MFCD00044928 | 318.410 | C11H7KN2O3S2 | 95.000 | [K+].Oc1ccc2nc(sc2c1)C1=N[C@H](CS1)C([O-])=O | 250mg | 482922421
D-Luciferin potassium salt | Chemodex Ltd. | 115144-35-9 | MFCD00044928 | 318.410 | C11H7KN2O3S2 | 95.000 | [K+].Oc1ccc2nc(sc2c1)C1=N[C@H](CS1)C([O-])=O | 250mg | 482922421