DNA Degradase™ is ideal for whole-genome DNA methylation analysis by a number of downstream applications (i.e., HPLC, TLC, etc.). Digestion with the enzyme is performed via a one-step procedure that is faster and simpler than other available methods.DNA Degradase™degrades DNA to individual nucleotides.Quantitation of nucleotides to detect DNA methylation levels can be assessed by various applications (e.g.- TLC, HPLC, etc.). For detection of DNA methylation via LC/MS, DNA needs to be degraded down to individual nucleosides.