General Clinical Chemistry Analyzers and Accessories
Abcam CCG 1423, Rho pathway-mediated signaling inhibitor, 5MG
MW 454.7 Da, Purity >98%. Specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Displays activity in several in vitro cancer cell functional assays. Potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, inhibits growth of RhoC-overexpressing melanoma lines at nanomolar concentrations. Selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell lines. Acts at or downstream of MLK1 and upstream of SRF. Blocks MLK1 nuclear localization.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Apremilast, 5MG
MW 460.5 Da, Purity >98%. Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam INDY, DYRK1A/B inhibitor, 5MG
MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Vistusertib (AZD2014), 5MG
MW 462.5 Da, Purity >98%. Novel potent and selective mammalian rapamycin (mTOR) inhibitor (IC₅₀ = 2.8 nM). Highly selective against multiple PI3K isoforms. Also targets P-Akt (IC₅₀ = 80 nM) and pS6 (IC₅₀ = 200 nM). An oral inhibitor with potential anti-neoplastic activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 10MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB-525334, TGFBR1 inhibitor., 25MG
MW 343.4 Da, Purity >98%. Cell permeable, potent, selective transforming growth factor beta 1 receptor (ALK5) (IC₅₀ = 14.3 nM) and ALK4 (IC₅₀ = 58.5 nM) inhibitor, with no activity at ALK2, 3 and 6 (IC₅₀ > 10 μM). Blocks fibrosis and renal injury markers in a puromycin-induced nephritis model. Causes significant attenuation in Smad2/3 nuclear translocation and a decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis.
The product is subject to the following: Abcam Restricted Use Statement
Compass Instruments SETAVAP4 AUTOMATIC ANALYZER
SetaVap4 Automatic Vapor Pressure Analyzer, according to ASTM D5191, D5188, D6377, D6378, IP 394, EN 13016-1 & 3. Includes waste container, sample inlet tube, mains lead and operating manual.• Rapid automatic vapor pressure testing• 0 to 1000 kPa• Piston based design for triple and single expansion test methods• Peltier cells for heating and cooling• Integrated shaker for crude oil measurements• 8.4” touchscreen display• Integrated statistical quality control (SQS) software, compliant with ASTM D6299• Simple test procedure• Internal result storage with USB port for data download• Compact, rugged design ideal for portable field or laboratory use• DVPE, RVP, EPA and CARB calculations• For operation at 115V, 60 Hz.
Abcam Ryuvidine, 1MG
MW 284.3 Da, Purity >98%. Inhibits (IC₅₀ = 500 nM) KMT5A / SETD8 / Pr-SET7 and suppresses H4JK20 monomethylation in vitro. Weakly active against Cdk4 (IC₅₀ = 6 μM). Induces S-phase accumulation in HEK-293 cells. Cytotoxic towards a number of human cancer cell lines. May induce the DNA damage response.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WH-4-023, 5MG
MW 568.7 Da, Purity >98%. Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC₅₀ values of 2 nM for Lck and 6 nM for Src.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Umifenovir, 5MG
MW 477.4 Da, Purity >=95%. An indole derivative with broad-spectrum antiviral activity. It inhibits virus-mediated fusion with target membrane and blocks virus entry into target cells. It shows antiviral activity against many enveloped or non-enveloped RNA or DNA viruses with IC₅₀ values ranging from 0.41 to 16 uM. It (50 or 100 mg/kg/day) reduces mean pulmonary virus yields and the rate of mortality in mice infected with FLU-A (A/PR/8/34 H1N1). Molecular dynamics and structural analysis show that Umifenovir may target SARS-CoV-2 spike glycoprotein and may block its trimerization which will reduce cell adherence and virus entry.
The product is subject to the following: Abcam Restricted Use Statement
Abcam MM-102 (HMTase Inhibitor I x ), 5MG
MW 669.8 Da, Purity >=98%. MM-102 (HMTase Inhibitor IX) is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis. WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Acetazolamide, carbonic anhydrase inhibitor, 5MG
MW 222.3 Da, Purity >98%. Non-specific carbonic anhydrase inhibitor with diverse physiological effects that are cell and tissue specific. Heterocyclic primary sulfonamide.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Miglustat hydrochloride, 1MG
MW 255.74 Da, Purity >=98%. An inhibitor of the N-linked oligosaccharide processing enzymes α-glucosidase I and II. It inhibits rat testicular enzymes ceramide-glucosyltransferase and beta-glucosidase 2 with IC₅₀ values of 32 and 81 μM respectively. Miglustat is used for the treatment of type 1 Gaucher's disease. It is an inhibitor of HIV replication in vitro. It shows activity against SARS-CoV-2 in vitro with EC₅₀ values in the micromolar range.
The product is subject to the following: Abcam Restricted Use Statement