General Clinical Chemistry Analyzers and Accessories
Abcam LGK974, 1MG
MW 396.4 Da, Purity >=98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LRRK2-IN-1, LRRK2 inhibitor, 10MG
MW 570.7 Da. Potent and selective inhibitor of the Parkinson's disease kinase LRRK2. Benzodiazepine based derivative. Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC₅₀ values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN-γ-induced monocyte maturation in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Alkali Scientific 5mL False Bottom Analyzer Tubes with Threads, 16×97mm, Polypropylene (PP), Amber, 1000/Pk
These 5mL False Bottom Analyzer Tubes (16×97mm) with Threads are designed for use in high volume chemistry and diagnostic analyzers. They are compatible with popular analyzers from Hitachi, Olympus, Corning, Ortho, Kodak, Beckman, IA, Tosoh, Vitros and more. Manufactured from high grade polypropylene (PP), these tubes offer excellent chemical resistance and can be safely autoclaved at 121 °C. With a conical false bottom for reduced dead volume and accurate sample retrieval, these tubes are ideal for serum collection, sample transport, or storage. Available in natural or amber options to protect light sensitive samples, they are self standing and designed to fit most universal analyzer racks, including AU 5000 systems. Features: 5mL nominal capacity, 16×97 mm Compatible with Hitachi, Olympus, Corning, Ortho, Beckman, Vitros, Tosoh, and other analyzers Made of chemical resistant polypropylene; autoclavable at 121 °C Available in natural or amber PP for light sensitific.
Abcam 7-Cl-O-Nec1, metabolically stable RIP1 inhibitor, 5MG
MW 277.7 Da, Purity >98%. Necrostatin-1 (ab141053) analog with superior selectivity and metabolic stability in blocking RIP1. No off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1. Higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC₅₀ = 210 nM vs. EC₅₀ = 490 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ledipasvir, 5A of hepatitis C virus inhibitor, 500UG
MW 889 Da. Ledipasvir is an inhibitor of non-structural protein 5A of hepatitis C virus. It has potent effects against genotypes 1a, 1b, 4a, and 5a in vitro, but has lower activity against genotypes 2a and 3a. Ledipasvir can have additive to synergistic in vitro antiviral activity when combined with other agents.
The product is subject to the following: Abcam Restricted Use Statement
Abcam BAY-299, TAF1 and BRD1 inhibitor, 10MG
MW 429.5 Da, Purity >98%. Potent and selective bromodomain inhibitor of TAF1 (IC₅₀ = 8-13 nM) and BRD1 (IC₅₀ = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC₅₀ = 0.58 μM) and TAF1 (IC₅₀ = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC₅₀ = 0.83 μM) and TAF1 (IC₅₀ = 1.4 μM) binding to Histone H3.3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Daclatasvir (BMS-790052), HCV NS5A protein inhibitor, 50MG
MW 738.9 Da, Purity =97%. Daclatasvir a potent, direct acting, small molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC₅₀ values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also inhibits infection by the JFH-1 genotype 2a virus in cultured cells. Daclatasvir is thought to inhibit relication of the HCV viral genome by affecting the subcellular localization of HCV NS5A and preventing its incorporation into relication complexes. In HCV-infected Huh7 cells, Daclatasvir (1 nM) inhibits viral RNA synthesis and viron assembly. Daclatasvir displays moderate activity against the OAT1B1 (IC₅₀ = 1.5 μM) and OAT1B3 (IC₅₀ = 3.27 μM) organic anion transporters.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sitravatinib, 5MG
MW 629.7 Da, Purity =98%. Broad spectrum receptor tyrosine kinase inhibitor (e.g. Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3). Better efficacy in mouse models than imatinib and crizotinib.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ABT-199 (Venetocla x ), Bcl-2 inhibitor., 1MG
MW 868.4 Da, Purity >98%. Potent, selective Bcl-2 inhibitor (Ki <0.01 nM) that inhibits the growth of Bcl-2–dependent tumors while sparing platelets. Bcl-2–specific BH3 mimetic. Promising agent in the treatment of chronic lymphocytic leukaemic and estrogen receptor-positive breast cancer.
The product is subject to the following: Abcam Restricted Use Statement
Abcam RITA, p53 activator, 5MG
MW 292.4 Da, Purity >98%. p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
The product is subject to the following: Abcam Restricted Use Statement
Thermo Scientific THERMO ELECTRON NORTH AMERICA LLC
NC4029728 KIT 42IQ NOX ANALYZER SPARE
Abcam ML-385, 25MG
MW 511.6 Da, Purity >=98%. A potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Cefpodoxime
Chemical. CAS 80210-62-4. Formula C15H17N5O6S2. MW 427.46. Synthetic. Cefpodoxime is a metabolite of cefpodoxime proxetil, an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria MIC90 ranges from 0.015-8 µg/ml. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls.
AdipoGen Ohira-Bestmann Reagent
Chemical. CAS 90965-06-3. Formula C5H9N2O4P. MW 192.11. Synthetic. Used in the Seyferth-Gilbert homologation which is a chemical reaction of an aryl ketone or aldehyde with dimethyl- or diazomethyl-phosphonate and potassium tert-butoxide to give substituted alkynes.
AdipoGen Etobenzanid
Chemical. CAS 79540-50-4. Formula C16H15Cl2NO3. MW 340.2. Synthetic. Herbicide. Compound can be used as analytical reference material.